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1.
BMC Pharmacol Toxicol ; 17: 1, 2016 Jan 04.
Artigo em Inglês | MEDLINE | ID: mdl-26729401

RESUMO

BACKGROUND: One of the most unfortunate events toddlers may encounter during their early years of curiosity and experimentation is substance poisoning. The aim of the study was to evaluate the poison severity score and its associated factors among toddlers with orally ingested substances at a pediatrics emergency department (ED), central Saudi Arabia. METHODS: A cross-sectional, poisoning report review between 2009&2011 was conducted. Exposures were patient characteristics (sex, age, body mass index, medical history) and incident characteristics (substance type, amount, form, witnessed or not, home remedy, arrival time to ED). Outcome was Poison Severity Score (PSS) that rates signs/symptoms of 11 body aspects on scale 0-4 (none, minor, moderate, severe, fatal). INCLUSION CRITERIA: age (1-3 years), previously healthy and oral exposure route. Bivariate analysis and multi-linear regression were conducted. Significance at p < 0.05. RESULTS: Eligible cases were 165/315(52 %). Males (58 %) and females (42 %) had normal BMI (70 %). Substances ingested were medications (60 %) and chemicals (40 %). Almost 85 % were witnessed incidents and 27 % received a home remedy (water, juices, dairy products, salt/sugar solutes, and/or manually induced vomiting). Delayed arrival (≥1 hour) was observed in 57 %. Composite mean PSS of total was (0.16 ± 0.21), and was highest at the gastrointestinal (GI) aspect (0.39 ± 0.63), metabolic balance (0.35 ± 0.60), and respiratory aspect (0.30 ± 0.61). Significantly associated factors with higher severity scores were: home remedies at the composite mean PSS (adj.p = 0.048), chemical poisoning at two aspects respiratory (adj.p = 0.047) and muscular (adj.p = 0.009) compared to medication poisoning. Unwitnessed incidents at the muscular aspect (adj.p = 0.026) compared to witnessed incidents; delayed arrival time to ED at three aspects GI (adj.p = 0.001), nervous system (adj.p = 0.014) and kidney (adj.p < 0.001). CONCLUSIONS: Parents are not recommended to provide any home remedy to their orally poisoned toddlers, but rather directly visit the ED. Physicians are expected to observe more severe clinical outcomes among toddlers with chemical poisoning, unwitnessed incidents, and delayed arrival times especially at the respiratory, GI, muscular, nervous and kidney aspects.


Assuntos
Comportamento Infantil , Comportamento Alimentar , Comportamento do Lactente , Intoxicação/diagnóstico , Tempo para o Tratamento , Pré-Escolar , Estudos Transversais , Serviço Hospitalar de Emergência , Feminino , Seguimentos , Humanos , Lactente , Masculino , Pais , Intoxicação/epidemiologia , Intoxicação/fisiopatologia , Intoxicação/terapia , Prognóstico , Estudos Retrospectivos , Risco , Arábia Saudita/epidemiologia , Índice de Gravidade de Doença , Centros de Atenção Terciária
2.
Medicine (Baltimore) ; 94(52): e2339, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26717371

RESUMO

Admission rate and length of stay (LOS) are two hospital performance indicators that affect the quality of care, patients' satisfaction, bed turnover, and health cost expenditures. The aim of the study was to identify factors associated with higher admission rates and extended average LOS among acutely poisoned children at a single poison center, central Saudi Arabia.This is a cross-sectional, poison and medical chart review between 2009 and 2011. Exposures were child characteristics, that is, gender, age, body mass index (BMI), health history, and Canadian 5-level triage scale. Poison incident characteristics were, that is, type, exposure route, amount, form, home remedy, and arrival time to center. Admission status and LOS were obtained from records. Chronic poisoning, plant allergies, and venomous bites were excluded. Bivariate and regression analyses were applied. Significance at P < 0.05.Of the 315 eligible cases, (72%) were toddlers with equal gender distribution, (58%) had normal BMI, and (77%) were previously healthy. Poison substances were pharmaceutical drugs (63%) versus chemical products (37%). Main exposure route was oral (98%). Home remedy was observed in (21.9%), which were fluids, solutes, and/or gag-induced vomiting. Almost (52%) arrived to center >1 h. Triage levels: non-urgent cases (58%), less urgent (11%), urgent (18%), emergency (12%), resuscitative (1%). Admission rate was (20.6%) whereas av. LOS was 13 ±â€Š22 h. After adjusting and controlling for confounders, older children (adj.OR = 1.19) and more critical triage levels (adj.OR = 1.35) were significantly associated with higher admission rates compared to younger children and less critical triage levels (adj.P = 0.006) and (adj.P = 0.042) respectively. Home remedy prior arrival was significantly associated with higher av. LOS (Beta = 9.48, t = 2.99), compared to those who directly visited the center, adj.P = 0.003.Hospital administrators are cautioned that acutely poisoned children who received home remedies prior arrival are more likely to endure an extended LOS. This non-conventional practice is not recommended.


Assuntos
Acidentes Domésticos/estatística & dados numéricos , Serviços Médicos de Emergência , Serviço Hospitalar de Emergência/estatística & dados numéricos , Intoxicação , Triagem , Adolescente , Criança , Pré-Escolar , Estudos Transversais , Serviços Médicos de Emergência/métodos , Serviços Médicos de Emergência/estatística & dados numéricos , Feminino , Substâncias Perigosas/toxicidade , Humanos , Lactente , Tempo de Internação/estatística & dados numéricos , Masculino , Preparações Farmacêuticas , Intoxicação/diagnóstico , Intoxicação/epidemiologia , Intoxicação/etiologia , Intoxicação/terapia , Arábia Saudita/epidemiologia , Triagem/métodos , Triagem/normas
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