[Decrease of mutagenic action of cyclophosphamide by buckwheat melanin preparation]. / Umen'shenie mutagennogo deistviia tsiklofosfamida preparatom melanina iz grechikhi.

Melanins are polyphenolic pigments of plants, animals and microbes with antioxidant and antiradiation activity. Water-soluble melanin from buckwheat is experienced as antimutagenic means (0.01-10 mg/kg per os) for cyclophosphamide (20 mg/kg i.p.) in the 3 series of experiments. The frequency of chromosome aberrations in the cells of mice bone marrow after mutagene is reduced 2-6 times once under influence of melanin.

[Effect of plant melanin pigment on the clastogenic effects of chemical mutagens in mice]. / Vliianie rastitel'nogo melaninovogo pigmenta na klastogennye éffekty khimicheskikh mutagenov u myshei.

The chromosome aberration assay in the bone marrow cells of C57BL/6 mice showed that melanin pigment (MP) in a dose range from 0.01 to 10 mg/kg does not influence the clastogenic effect of dioxidine (200 mg/kg, i.p.), while reducing the clastogenic effect of cyclophosphamide (20 mg/kg, i.p.) by a factor of 1.5-4 in various treatment regimes depending on the mutagen injection time.