RESUMO
No curative or fully effective treatments are currently available for Alzheimer's disease (AD), the most common form of dementia. Electrical stimulation of deep brain areas has been proposed as a novel neuromodulatory therapeutic approach. Previous research from our lab demonstrates that intracranial self-stimulation (ICSS) targeting medial forebrain bundle (MFB) facilitates explicit and implicit learning and memory in rats with age or lesion-related memory impairment. At a molecular level, MFB-ICSS modulates the expression of plasticity and neuroprotection-related genes in memory-related brain areas. On this basis, we suggest that MFB could be a promising stimulation target for AD treatment. In this study, we aimed to assess the effects of MFB-ICSS on both explicit memory as well as the levels of neuropathological markers ptau and drebrin (DBN) in memory-related areas, in an AD rat model obtained by Aß icv-injection. A total of 36 male rats were trained in the Morris water maze on days 26-30 after Aß injection and tested on day 33. Results demonstrate that this Aß model displayed spatial memory impairment in the retention test, accompanied by changes in the levels of DBN and ptau in lateral entorhinal cortex and hippocampus, resembling pathological alterations in early AD. Administration of MFB-ICSS treatment consisting of 5 post-training sessions to AD rats managed to reverse the memory deficits as well as the alteration in ptau and DBN levels. Thus, this paper reports both cognitive and molecular effects of a post-training reinforcing deep brain stimulation procedure in a sporadic AD model for the first time.
Assuntos
Doença de Alzheimer , Terapia por Estimulação Elétrica , Feixe Prosencefálico Mediano , Transtornos da Memória , Animais , Masculino , Ratos , Doença de Alzheimer/terapia , Peptídeos beta-Amiloides , Modelos Animais de Doenças , Feixe Prosencefálico Mediano/fisiologia , Transtornos da Memória/terapia , Ratos Wistar , Memória Espacial/fisiologia , Terapia por Estimulação Elétrica/métodosRESUMO
No disponible
Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Aumento de Peso , Diálise Peritoneal/métodos , Suplementos Nutricionais/efeitos adversos , Suplementos Nutricionais , Insuficiência Renal Crônica/complicações , Peso Corporal , Peso Corporal/fisiologia , Hipoalbuminemia/complicaçõesRESUMO
El propósito de este estudio fue determinar la eficacia de un programa de ejercicios de fuerza-resistencia durante la hemodiálisis, en la mejora de la fuerza muscular, calidad de vida y capacidad funcional para la realización de actividades de la vida diaria. Se realizó un estudio cuantitativo y experimental de tipo pretest y postest. Se aplicó un programa de ejercicios de fuerzaresistencia en combinación con electroestimulación neuromuscular a 10 pacientes sometidos a hemodiálisis. Fueron tres ejercicios de sencilla ejecución adaptados a la posición en la que se realizaba la hemodiálisis. Todos los pacientes mostraron una mejoría significativa en la fuerza, medida mediante test funcionales para la realización de las actividades de la vida diaria: caminar (6-MWT) y sentarse-levantarse (10-STS). Estos test fueron medidos antes y después del programa de entrenamiento. También mostraron mejoría en la dimensión física de la calidad de vida medida mediante el cuestionario específico para el enfermo renal, el KDQOL-SFTM (AU)
The purpose of this study was to determine the efficacy of a programme of strength-stamina exercises during haemodialysis, in improving muscular strength, quality of life and functional capacity to carry out everyday activities. A quantitative, experimental pre-test and post-test study was carried out. A programme of strength-stamina exercises in combination with neuromuscular electrostimulation was applied to 10 patients undergoing haemodialysis. These were three simple exercises adapted to the position in which haemodialysis was carried out. All the patients showed a significant improvement in strength, measured using functional tests to carry out everyday activities: walking (6-MWT) and sitto- stand tests (10-STS). These tests were measured before and after the training programme. They also showed an improvement in the physical dimension of the quality of life measured using the specific questionnaire for renal patients, KDQOL-SFTM (AU)