RESUMO
We investigated whether exposure to the odor of extracted cedar essence (CE) has (i) an influence on spontaneous activity and sleep-wake states of rats and (ii) a sleep-promoting effect on human daytime nap after taking an ordinary night's sleep. In rats exposed to CE, spontaneous activities and amount of wake were significantly decreased, while the amount of non-rapid eye movement (NREM) sleep was significantly increased. In human daytime nap, NREM sleep stage 2 latency was significantly shortened after exposure to CE.
Assuntos
Ritmo Circadiano/efeitos dos fármacos , Óleos Voláteis/farmacologia , Óleos de Plantas/farmacologia , Fases do Sono/efeitos dos fármacos , Vigília/efeitos dos fármacos , Animais , Análise de Fourier , Humanos , Masculino , Odorantes , Polissonografia , Ratos , Tempo de Reação/efeitos dos fármacos , Processamento de Sinais Assistido por Computador , Sono REM/efeitos dos fármacos , ÁrvoresRESUMO
We report here an autopsy case of Binswanger's disease (BD) without hypertension and associated with cerebral infarction in the terminal stage. The female patient, who was 74 years old at the time of death, had initially demonstrated manic-depressive disorder-like mental disorder, followed by dementia and neurological deficits. A brain CT scan showed white matter low attenuation bilaterally and symmetrically. BD was clinically diagnosed despite the lack of hypertension. In the terminal stage, she suffered an infarction in the left anterior cerebral artery region, and died of pneumonia. Neuropathologically, we found the infarction of the left anterior cerebral artery region, demyelination, fibrillary gliosis, lacunae and arteriosclerosis of the small arteries and arterioles in the white matter.
Assuntos
Dano Encefálico Crônico/patologia , Encéfalo/patologia , Infarto Cerebral/patologia , Hipertensão/patologia , Idoso , Dano Encefálico Crônico/genética , Artérias Cerebrais/patologia , Córtex Cerebral/patologia , Infarto Cerebral/genética , Feminino , Humanos , Hipertensão/genética , Arteriosclerose Intracraniana/genética , Arteriosclerose Intracraniana/patologia , Imageamento por Ressonância Magnética , Exame Neurológico , Tálamo/patologia , Tomografia Computadorizada por Raios XRESUMO
To verify the efficacy of a weak diffuse-brain-stimulation (DBS) method that was specially devised by this research team, a weak DBS was administered to seven male inpatients, who had vibration syndrome due to a prolonged use of a vibratory tool and who were simultaneously complaining of insomnia. Sleep data obtained from the polygraphic recordings on the DBS-treated night were compared with those on the pseudo DBS-treated. As the result, this DBS method proved to be effective in improving patients' sleep initiation and/or maintenance, and also their subjective ratings on the quality of actual sleep. In conclusion, the present DBS was determined to produce a decrease in the sympathetic tone which is needed at the onset of sleep.
Assuntos
Encéfalo/fisiopatologia , Terapia por Estimulação Elétrica , Distúrbios do Início e da Manutenção do Sono/terapia , Vibração , Adulto , Humanos , Masculino , Pessoa de Meia-Idade , Distúrbios do Início e da Manutenção do Sono/etiologia , Distúrbios do Início e da Manutenção do Sono/fisiopatologia , SíndromeRESUMO
An autopsy case of progressive supranuclear palsy with onset at age 53 and a clinical course of 7 years is reported. The clinico-pathological characteristics of the case were as follows: Fibrillary gliosis of the midbrain and pontine reticular formation corresponded clinically to personality changes: The patient had formerly been irascible and became extremely mild-mannered. He showed lack of spontaneity and initiative and slowing of thought processes, taking him longer than normal to find words and ideas. Gliosis of the nucleus ventralis lateralis of the thalamus was secondary to the degeneration of the cerebellar dentate nucleus and the globus pallidus from which they receive fibers. Neurofibrillary tangles were found in the cerebral cortex.