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Fitoterapia ; 166: 105463, 2023 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-36848964

RESUMO

Four new compounds (1-4), together with 23 known compounds (5-27), were isolated from the whole plant of Taraxacum mongolicum. Among them, one racemic mixture (4) was separated with a chiral HPLC column. Their structures were identified by spectroscopic evidence and mass spectrometry. The absolute configurations of compounds 1, 3, and 4 were determined via comparison of their calculated and experimental electronic circular dichroism (ECD) spectra. Compound 3 showed an inhibitory effect against aldose reductase with a 59.1% inhibition. Two known compounds (13 and 27) showed α-glucosidase inhibition of 51.5% and 56.0%, respectively.


Assuntos
Alcaloides , Sesquiterpenos , Taraxacum , Taraxacum/química , Furaldeído , Estrutura Molecular , Fenóis/farmacologia , Alcaloides/farmacologia , Dicroísmo Circular , Sesquiterpenos/farmacologia
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