RESUMO
This paper gives an account of an experimental and clinical application of super-low frequency scanning magnetic field in patients with noninvasive bladder cancer treated with adjuvant intravesical gemcitabine chemotherapy. Treatment of isolated bladder cancer cells incubated with gemcitabine by this physical factor increased the permeability of cell membranes to the chemotherapy drug. This effect was demonstrated by increased fluorescence intensity of cancer cells. Clinical application of this combination therapy technology showed 2,8-fold increase of disease-free survival interval compared to early recurrences in the control group. These results indicate the potential of biophysical mechanisms to increase chemotherapy effectiveness.
Assuntos
Antimetabólitos Antineoplásicos/administração & dosagem , Desoxicitidina/análogos & derivados , Magnetoterapia/métodos , Neoplasias da Bexiga Urinária/terapia , Desoxicitidina/administração & dosagem , Feminino , Humanos , Masculino , Neoplasias da Bexiga Urinária/patologia , GencitabinaRESUMO
139 patients with achalasia of cardiac orifice among which two third were women and one third--men aged 20-65 years have been observed. 97 patients (69.7%) were treated by cardiodilatation. 17 patients (22.3%) of the main group were treated with pneumocardiodilatation. 44 patients (57.3%) underwent cardiodilatation with the help of pneumo-cardiodilatator improved by the author and electrostimulation. Cardiodilatation technique in a complex treatment of achalasia of cardiac orifice was substantiated by the author.