1.
Bioorg Med Chem Lett
; 14(7): 1761-4, 2004 Apr 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15026066
RESUMO
A series of substituted 4-alkoxy-2-aminopyridines 2, which were formally derived from neuropeptide Y1 antagonist 1 by replacing the morpholino portion with alkoxy groups, were synthesized and evaluated as neuropeptide Y Y1 receptor antagonists. Primary structure-activity relationships and identification of potent 4-alkoxy derivatives are described.