Nootropic Effects of Filipendula Vulgaris Moench Water Extract Fractions.

Nootropic activity of water extract fractions from aerial parts of Filipendula vulgaris Moench was demonstrated on the models of hermetic volume hypoxia, conditioned passive avoidance response, open field test, and forced swimming with a load. The fractions stimulated hypoxic resistance, normalized orientation and exploratory behavior, improved conditioned response reproduction during testing after hypoxic injury, and increased exercise tolerance. Fractionation of the extract led to dissociation of the effect components, which suggests that individual constituents have specific characteristics. Ethylacetate fraction exhibited most pronounced nootropic activity and was superior to plant extract by some characteristics. The detected effects seemed to be caused by modulation of the hippocampus activity the under the effects of phenol and triterpene compounds.

Nootropic effect of meadowsweet (Filipendula vulgaris) extracts.

The effects of the extracts of the aboveground parts of Filipendula vulgaris Moench on the behavior and memory of mice after hypoxic injury and their physical performance in the open-field test were studied using the models of hypoxia in a sealed volume, conditioned passive avoidance response (CPAR), and forced swimming with a load. The extracts improved animal resistance to hypoxia, normalized orientation and exploration activities, promoted CPAR retention after hypoxic injury, and increased physical performance. Aqueous extract of meadowsweet had the most pronounced effect that corresponded to the effect of the reference drug piracetam. These effects were probably caused by modulation of hippocampal activity.

[EFFECT OF SYNTHETIC ANTIOXIADNT THIOPHAN AND SCUTELLARIA BAICALENSIS ROOT EXTRACT ON DRUG-INDUCED MUTAGENESIS].

Gene protective properties of synthetic antioxidant thiophane and the extract of in vitro cultivated roots of Scutellaria baicalensis were studied on the model of Dr. melanogaster larvae genetic structure damage by drugs cisplatin and cyclophosphan (cyclophosphamide). It is established that adding thiophane or Scutellaria baicalensis root extract to a nutrient medium leads to a decrease in amount of Dr. melanogaster recombinants (females bearing recessive yellow and/or singed marker mutations).

[Effect of Scutellaria baicalensis root extract on cytogenetic damage induced by paclitaxel and cisplatin in mice].

The effect of root extract of Baikal skullcap (Scutellaria baicalensis) cultivated in vitro, on the gene structure of CBA/CaLac mice bone marrow cells damaged by anticancer drugs paclitaxel and cisplatin has been studied. It is established that the root extract exhibits gene protective property upon both single and chronic administration.

Nootropic activity of extracts from wild and cultivated Alfredia cernua.

Antihypoxic and nootropic activities of extracts from aerial parts of wild and cultivated Alfredia cernua (L.) Cass. were studied on the models of pressure chamber hypoxia, open field test, and passive avoidance conditioning. The extracts of Alfredia cernua promoted retention of the orientation reflex and passive avoidance conditioned response and normalized orientation and exploratory activities disordered as a result of hypoxic injury. The efficiency of the extracts was superior to that of piracetam by the effect on retention of passive avoidance response throughout the greater part of the experiment. Nootropic activity of cultivated Alfredia cernua was not inferior to that of the wild plant.

[Effect of Alfredia cernua extracts on the behavior, memory, and physical work capacity of experimental animals].

It is established, that Alfredia cernua extracts possess nootropic properties. The extracts favor improvement of the indices of orientation and exploration behavior, retention of the passive avoidance reflex upon hypoxic shock, and increase in physical work capacity in mice. The most pronounced effect was observed upon the administration of a 95% ethanol extract of Alfredia cernua.

[Effect of Filipendula ulmaria extract on immune system of CBA/CaLac and C57Bl/6 mice].

Extract of Filipendula ulmaria (L.) Maxim administered intragastrically in doses 10, 50, 150 and 500 mg/kg stimulated both inductive and productive phases of the humoral immunity response in CBA/CaLac and C57BL/6 mice. The extract also exhibited pronounced antiinflammatory effect, which was manifested by a decrease in the synthesis of interleukin-2 by splenocytes and by suppression of proinflammatory cytokines production in delayed-type hypersensitivity reaction. At the same time, Filipendula ulmaria extract did not influence the functional activity of peritoneal macrophages.

Hepatoprotective properties of fractions from meadowsweet extract during experimental toxic hepatitis.

Fractions of the extract from meadowsweet aerial parts in 70% ethanol exhibited hepatoprotective properties during CCl4-induced toxic hepatitis. This extract produced a normalizing effect on activity of enzymes, markers of cytolysis, lipid peroxidation, and antioxidant defense system in liver cells. Fractionation of the extract was accompanied by dissociation of the effect. These changes reflect specific action of a complex of bioactive substances. The ethyl acetate and chloroform fractions from this extract were most potent. The effectiveness of these fractions by several parameters surpassed that of Carsil.

Hepatoprotective and antioxidant activity of meadowsweet extract during experimental toxic hepatitis.

The extract of meadowsweet aerial parts exhibits hepatoprotective and antioxidant activity during experimental toxic CCl(4) hepatitis. This extract improved liver function. Meadowsweet extract in 70% ethanol (100 mg/kg) was most potent and exhibited low toxicity. By several parameters the effectiveness of this extract surpassed that of Carsil.