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Objective::To explore the mechanism of Xiao Banxiatang in preventing and treating chemotherapy-induced nausea and vomiting by using network pharmacology. Method::The targets of chemotherapy-related nausea and vomiting were collected by therapeutic target database (TTD), Drugbank database and DisGeNET database. The target genes were normalized by Uniprot database. The traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP) was selected according to oral bioavailabilityc (OB) ≥ 30%, drug-likeness (DL) ≥ 0.14 and the literature research. The active constituents of pinellia ternata and ginger were collected through the PubChem database, the ALOGPS2.1 database and the Swiss Target Prediction database, and the target of ginger was collected and standardized through the Uniprot database, the molecular inverse docking of the important component 6-gingerol was carried out through the DRAR-CPI database, gene ontology (GO) analysis and kyoto encyclopedia of genes and genomes (KEGG) pathway analysis were performed through DAVID 6.8 database, and relationship diagrams were drawn by Cytoscape 3.2.1 software and network topology parameters were analyzed, GO and KEGG bubble maps were drawn by ImageGP tool. Result::A total of 148 targets for chemotherapeutic nausea and vomiting, and 27 active ingredients of Xiao Banxiatang were collected, including 22 associated with chemotherapeutic nausea and vomiting, 38 control targets, 67 biological processes based on GO analysis, 11 cell components, 18 molecular functions, 21 KEGG pathways, involving cyclic Adenosine monophosphate (cAMP) signaling pathway, calcium signaling pathway, Rap1 signaling pathway. Conclusion::Based on network pharmacology, chemotherapy-related nausea and vomiting and Xiao Banxiatang were analyzed to provide ideas for the prevention and treatment of chemotherapy-induced nausea and vomiting.
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OBJECTIVE@#To compare the therapeutic effect of plum-blossom needle tapping at three meridians of wrist combined with rehabilitation training and simple rehabilitation training on wrist joint contracture after stroke.@*METHODS@#A total of 72 patients with wrist joint contracture after stroke were randomized into an observation group and a control group, 36 cases in each one. In the control group, simple rehabilitation training was applied, 5 times a week, 3 weeks as one course and totally 3 courses were required. On the basis of the treatment in the control group, plum-blossom needle tapping at three meridians of wrist was adopted in the observation group. The tapping regions were wrist traveling parts of three meridians of hand, ranging from up 3 to below 1 of wrist crease, 3 times a week, 3 weeks as one course and totally 3 courses were required. The active range of motion (AROM) of active wrist extension, Fugl-Meyer score (FMA) and Barthel index (BI) score were observed before and after treatment in the two groups.@*RESULTS@#The AROM, FMA scores and BI scores after treatment in the two groups were superior to before treatment (<0.05), and the improvements of 3 indexes in the observation group were superior to the control group (<0.05).@*CONCLUSION@#The therapeutic effect of plum-blossom needle tapping at three meridians of wrist combined with rehabilitation training is superior to simple rehabilitation training on wrist joint contracture after stroke.