RESUMO
Elaeoselinum thapsioides (Desf.) Maire (Apiaceae) is an Algerian medicinal plant used in traditional medicine to treat different diseases. The essential oil obtained by hydrodistillation from the aerial parts of Elaeoselinum thapsioides growing wild in Algeria, was analyzed by GC-MS for the first time. Forty-five compounds were detected, accounting for 93.8% of the total oil, which was characterized by a high content of hydrocarbons derivatives of monoterpenes (75.9%). Myrcene (61.0%) was the principal constituent of the essential oil, followed by germacrene D (10.3%), α-pinene (6.5%) and ß-pinene (2.9%). In vitro anticholinesterase activity of the essential oil was investigated by the Ellman method that evidenced a low acetylcholinesterase and butyrylcholinesterase inhibitory effect.[Formula: see text].
Assuntos
Óleos Voláteis , Acetilcolinesterase/química , Butirilcolinesterase/química , Inibidores da Colinesterase/química , Inibidores da Colinesterase/farmacologia , Óleos Voláteis/química , Óleos Voláteis/farmacologia , ThapsiaRESUMO
The essential oils obtained by hydrodistillation from Daucus sahariensis Murb. harvested at three different growth stages were characterized by GC/MS analysis. In total, 88 compounds were identified, with myristicin (29.8-51.7%), myrcene (6.7-31.1%), α-pinene (11.6-14.8%), and limonene (5.3-11.5%) as main constituents. Monoterpene hydrocarbons were the most represented compounds in the oils of the plant samples collected during the flower-budding and full-flowering periods. On the contrary, during the fruiting stage, the oils were dominated by phenylpropanoids. The essential oils were subject of considerable variation in their composition during the various developmental stages, particularly concerning the content of myrcene that decreased significantly passing from the vegetative to the fruiting stage. Conversely, for myristicin, the opposite trend was observed. Furthermore, the essential-oil yields were quite low during the flower-budding phase (0.27%), but rapidly increased during plant development (0.63 and 0.68% for the flowering and fruiting phases, resp.).
Assuntos
Apiaceae/química , Apiaceae/crescimento & desenvolvimento , Óleos Voláteis/análise , Óleos de Plantas/análise , Monoterpenos Acíclicos , Alcenos/análise , Alcenos/metabolismo , Derivados de Alilbenzenos , Compostos de Benzil/análise , Compostos de Benzil/metabolismo , Monoterpenos Bicíclicos , Cicloexenos/análise , Cicloexenos/metabolismo , Dioxolanos/análise , Dioxolanos/metabolismo , Cromatografia Gasosa-Espectrometria de Massas , Limoneno , Monoterpenos/análise , Monoterpenos/metabolismo , Óleos Voláteis/metabolismo , Óleos de Plantas/metabolismo , Pirogalol/análogos & derivados , Pirogalol/análise , Pirogalol/metabolismo , Terpenos/análise , Terpenos/metabolismoRESUMO
The essential oils obtained by hydrodistillation from leaves and fruits of Daucus sahariensis Murb. were analyzed by GC/MS. The main constituents of the essential oil from the leaves were myristicin (34.3%), alpha-pinene (5.4%), cis-chrysanthenyl acetate (5.3%) and epi-alpha-bisabolol (4.8%), and those from the fruits myristicin (43.9%), alpha-pinene (13.1%), limonene (9.4%), and cis-chrysanthenyl acetate (7.4%). Myristicin, the main constituent of both essential oils, is generally absent in the oils from other Daucus species, permitting the hypothesis that this compound is a chemical marker of this Saharan species.