RESUMO
Balloon angioplasty and stenting have increasingly been gaining widespread application for treatment of post-thrombotic alterations in the system of the vena cava. Endovascular ultrasonographic examination makes it possible with the utmost degree of reliability to determine both the extension and degree of the narrowing of venous segments, thus proving a possibility of choosing a venous stent of an appropriate diameter. Restoration of an adequate venous lumen leads to normalization of blood flow and elimination of venous hypertension. However, unsolved as yet remains the problem concerning proper management of post-thrombotic obstructions of the inferior vena cava at the level of a cava filter. Owing to a wide variety of configurations of cava filters to deploy, there are no common approaches to elimination of such obstruction. Presented herein is a clinical case report regarding successful endovascular treatment of a patient diagnosed with post-thrombotic disease secondary to endured thrombosis. The findings of both phlebography and endovascular ultrasonographic examination made it possible to diagnose obstruction of the left common iliac vein, external iliac vein, and inferior vena cava to the level of the cava filter previously deployed. In the segment of the inferior vena cava at the level of the cava filter also revealed was a pronounced luminal narrowing exceeding 90% of its diameter. We carried out stenting of the common and external iliac veins, inferior vena cava, and the cava filter. Swelling of the left leg subsided spontaneously within 2 weeks and the first postoperative month was accompanied by gradual disappearance of the previously existing feeling of heaviness in the lower limbs and a dramatic decrease in fatigue by the end of the working day.
Assuntos
Angioplastia com Balão , Veia Ilíaca , Síndrome Pós-Trombótica , Stents , Filtros de Veia Cava/efeitos adversos , Veia Cava Inferior , Trombose Venosa/cirurgia , Adulto , Angioplastia com Balão/instrumentação , Angioplastia com Balão/métodos , Constrição Patológica/diagnóstico , Constrição Patológica/patologia , Constrição Patológica/fisiopatologia , Constrição Patológica/cirurgia , Procedimentos Endovasculares/métodos , Humanos , Veia Ilíaca/diagnóstico por imagem , Veia Ilíaca/cirurgia , Masculino , Flebografia/métodos , Síndrome Pós-Trombótica/diagnóstico , Síndrome Pós-Trombótica/patologia , Síndrome Pós-Trombótica/fisiopatologia , Síndrome Pós-Trombótica/cirurgia , Resultado do Tratamento , Ultrassonografia de Intervenção/métodos , Veia Cava Inferior/diagnóstico por imagem , Veia Cava Inferior/patologia , Veia Cava Inferior/cirurgia , Trombose Venosa/complicaçõesRESUMO
The chickweed (Stellaria media L.) pro-SmAMP2 gene encodes the hevein-like peptides that have in vitro antimicrobial activity against certain harmful microorganisms. These peptides play an important role in protecting the chickweed plants from infection, and the pro-SmAMP2 gene was previously used to protect transgenic tobacco and Arabidopsis plants from phytopathogens. In this study, the pro-SmAMP2 gene under control of viral CaMV35S promoter or under control of its own pro-SmAMP2 promoter was transformed into cultivated potato plants of two cultivars, differing in the resistance to Alternaria: Yubiley Zhukova (resistant) and Skoroplodny (susceptible). With the help of quantitative real-time PCR, it was demonstrated that transgenic potato plants expressed the pro-SmAMP2 gene under control of both promoters at the level comparable to or exceeding the level of the potato actin gene. Assessment of the immune status of the transformants demonstrated that expression of antimicrobial peptide pro-SmAMP2 gene was able to increase the resistance to a complex of Alternaria sp. and Fusarium sp. phytopathogens only in potato plants of the Yubiley Zhukova cultivar. The possible role of the pro-SmAMP2 products in protecting potatoes from Alternaria sp. and Fusarium sp. is discussed.
Assuntos
Alternaria , Peptídeos Catiônicos Antimicrobianos , Resistência à Doença/genética , Fusarium , Proteínas de Plantas , Plantas Geneticamente Modificadas , Solanum tuberosum , Peptídeos Catiônicos Antimicrobianos/biossíntese , Peptídeos Catiônicos Antimicrobianos/genética , Proteínas de Plantas/biossíntese , Proteínas de Plantas/genética , Plantas Geneticamente Modificadas/genética , Plantas Geneticamente Modificadas/metabolismo , Plantas Geneticamente Modificadas/microbiologia , Solanum tuberosum/genética , Solanum tuberosum/metabolismo , Solanum tuberosum/microbiologia , Stellaria/genéticaRESUMO
Antithrombotic activity of hypoglycemic compound limiglidole that exhibits antiplatelet activity 2-fold exceeded activity of antiplatelet agent acetylsalicylic acid in the mouse model of systemic collagen-epinephrine thrombosis. Limiglidole signifi cantly reduced the relative and mean area of blood clots in the sections of mouse lungs.
Assuntos
Benzimidazóis/uso terapêutico , Inibidores da Agregação Plaquetária/uso terapêutico , Embolia Pulmonar/prevenção & controle , Animais , Arteríolas/patologia , Aspirina/uso terapêutico , Benzimidazóis/farmacologia , Capilares/patologia , Colágeno/toxicidade , Avaliação Pré-Clínica de Medicamentos , Epinefrina/toxicidade , Eritrócitos/efeitos dos fármacos , Feminino , Hipoglicemiantes , Pulmão/irrigação sanguínea , Pulmão/patologia , Masculino , Camundongos , Inibidores da Agregação Plaquetária/farmacologia , Embolia Pulmonar/induzido quimicamente , Embolia Pulmonar/patologia , Migração Transendotelial e Transepitelial/efeitos dos fármacosRESUMO
Antithrombotic properties of a new P2Y1 receptor antagonist N-[(1-morpholinopropyl-amino)- carbonyl-2-(1-ethyl-1H-indole-3-yl)-vinyl]-4-methylphenyl-amide hydrochloride, substance Sbt-119, and reference drug ticlopidine were studied on experimental models of arterial and systemic thromboses. Substance Sbt-119 was 39.9% (p<0.05) more potent than ticlopidine in producing the antithrombotic effect. Moreover, substance Sbt-119 was shown to increase the survival rate of animals after systemic treatment with ADP (by 20%, p<0.0001). This substance decreased the number of mural thrombi and reduced the severity of hemodynamics disturbances in the organs during systemic thrombosis.
Assuntos
Fibrinolíticos/administração & dosagem , Indóis/administração & dosagem , Morfolinas/administração & dosagem , Antagonistas do Receptor Purinérgico P2Y/administração & dosagem , Trombose/tratamento farmacológico , Administração Oral , Animais , Animais não Endogâmicos , Avaliação Pré-Clínica de Medicamentos , Pulmão/patologia , Masculino , Camundongos , Ratos , Ticlopidina/farmacologiaRESUMO
Patterns of expression of TRPM7, the major cellular magnesium transporters in neurons of the hypothalamic region and hippocampus, were studied immunohistochemically. Multidirectional nature and different levels of the expression of the above antigen were revealed during modeled magnesium deficiency with regard to structural and functional features of neuron organization in the hypothalamic paraventricular and supraoptic nuclei as well as hippocampal field CA1 and CA3. Changes in the structural characteristics of neurons in the studied areas (absolute and relative indicators) and TRPM7 expression patterns were quantitatively analyzed considering the data on the role of the studied antigen in magnesium homeostasis, cell damage, and compensation.
Assuntos
Hipocampo/metabolismo , Hipotálamo/metabolismo , Deficiência de Magnésio/metabolismo , Neurônios/metabolismo , Canais de Cátion TRPM/biossíntese , Animais , Região CA1 Hipocampal/citologia , Região CA1 Hipocampal/metabolismo , Região CA3 Hipocampal/citologia , Região CA3 Hipocampal/metabolismo , Transporte de Íons , Magnésio , Masculino , Núcleo Hipotalâmico Paraventricular/citologia , Núcleo Hipotalâmico Paraventricular/metabolismo , Ratos , Núcleo Supraóptico/citologia , Núcleo Supraóptico/metabolismoRESUMO
The method of microcolumn reversed phase high performance liquid chromatography (rp-HPLC) was employed to determine the content of elemental sulphur in mineral waters. The study envisaged the analysis of the samples of sulphide-containing mineral waters Novonukutskaya and Matsesta obtained by the solid phase extraction technique. Based on these data, the authors discuss the origin and the circulation of sulphur in the hydrogen sulphide sources. The elution conditions selected in this study ensured the high-resolution separation of the octasulphur peak from the peaks of allotropic components of the extract whereas the two-wave detection technique allowed to identify the peaks of molecular sulphur.
Assuntos
Balneologia/métodos , Cromatografia Líquida de Alta Pressão/métodos , Estâncias para Tratamento de Saúde , Águas Minerais/análise , Enxofre/isolamento & purificação , Concentração de Íons de Hidrogênio , Federação RussaRESUMO
The solid-state extraction technique and chromatography mass spectrometry were used to study the intrinsic composition of organic components of the mineral water obtained from the Munok deposit located in the Kazachinsko-Lensk district, Irkutsk region. The active components determining the mechanism of action of a mineral water-based preparation were identified and showed to operate similarly to those of Naftusya mineral water. The balneotherapeutic preparation was fabricated making use of the earlier developed technology of water vapor distillation. The analysis of organic components of mineral water and its extraction products showed the presence of aliphatic hydrocarbons with the high content of unsaturated compounds. The preparation thus obtained, unlike the standard balneotherapeutic medicines, does riot contain an inorganic matrix; it was shown to increase body resistance in the phase of remission in the patients treated for the management of urolithiasis.
Assuntos
Alcanos/análise , Balneologia , Águas Minerais/análise , Cromatografia Gasosa-Espectrometria de Massas , Águas Minerais/normas , Sibéria , Extração em Fase SólidaRESUMO
A new technology for isolation of medicinal balneological preparations from mineral waters has been developed. It is based on the extraction of biologically active compounds (BAC) from mineral waters with ethanol following oxidative hydrolysis and water vapour distillation. This technology has no analogs both in this country and abroad. Unlike ordinary balneological medicines, those obtained by the new method do not contain inorganic matrix, show higher activity, and remain stable for a longer period. The primary composition of BACs isolated by the above technology was studied using solid-phase extraction and chromatomass-spectrometry. Analysis of Extramine, a medicinal preparation from Novonukutskaya hydrogen sulfide mineral water (Siberian Matsesta), allowed to identify active components responsible for its therapeutic effects and elucidate mechanisms of their action. The 15-year-long experience with practical application of BACs obtained with the help of the new technology has demonstrated that they possesses antiallergic, antiviral, and analeptic activities. These compounds increase general resistance of the organism to infection, promote removal of toxic substances, accelerate wound and injury healing, and prevent the development of herpes infection.
Assuntos
Balneologia/métodos , Suplementos Nutricionais , Águas Minerais/análise , Compostos de Enxofre/isolamento & purificação , Tecnologia Farmacêutica/métodosRESUMO
AIM: To define the impact of phosphorus and calcium metabolic disturbances in patients with early-stage chronic renal disease (CRD) on the cardiovascular system. SUBJECTS AND METHODS: The levels of phosphate (P), calcium, parathyroid hormone (PTH), 25(OH) vitamin D and 1,25(OH)2 vitamin D, serum lipidogram, carotid artery intima-media thickness (IMT), and X-ray degree of abdominal artery calcification (AAC) were determined and echocardiography, electrocardiography and blood pressure monitoring were made in 465 patients with Stages I-V CRD who did not receive renal replacement therapy (of them, 73.5% of the patients had early (I to III) stages). RESULTS: Blood 1,25(OH)2D was related inversely to left ventricular (LV) posterior wall thickness, blood pressure (BP), triglycerides, and the degree of AAC and correlated directly to the severity of LV diastolic dysfunction and inversely to IMT, the presence of coronary heart disease and heart failure (HF). ACC, LV hypertrophy, and arterial hypertension (AH) were more significant in patients with higher serum levels PTH and P. CONCLUSION: In patients with early-stage CRD, phosphorus and calcium metabolic disturbances promote the development of AH, vascular and cardiac valvular calcification, myocardial hypertrophy, and HF.
Assuntos
Cálcio/metabolismo , Sistema Cardiovascular/fisiopatologia , Nefropatias/metabolismo , Nefropatias/fisiopatologia , Fósforo/metabolismo , Cálcio/sangue , Doenças Cardiovasculares/sangue , Doenças Cardiovasculares/etiologia , Doenças Cardiovasculares/metabolismo , Doença Crônica , Di-Hidroxicolecalciferóis/sangue , Feminino , Humanos , Nefropatias/sangue , Nefropatias/complicações , Masculino , Hormônio Paratireóideo/sangue , Fósforo/sangue , Estações do Ano , Índice de Gravidade de DoençaRESUMO
The objective of the present work was to study the wound-healing potential of the new preparation, Extramin (a 32% ethanol extract of organic substances from Novonukutskaya mineral water) in a series of experiments on a model of chemical burns in rabbits. The wound healing process was monitored based on biochemical, hematiological, and morphological indicators. Analysis of the results allows for the conclusion that Extramin is a powerful stimulator of the wound-healing processes and can be recommended for further clinical studies.
Assuntos
Queimaduras Químicas/tratamento farmacológico , Águas Minerais , Cicatrização/efeitos dos fármacos , Resinas Acrílicas/administração & dosagem , Resinas Acrílicas/uso terapêutico , Administração Tópica , Animais , Queimaduras Químicas/diagnóstico , Modelos Animais de Doenças , Avaliação Pré-Clínica de Medicamentos , Coelhos , Federação RussaRESUMO
On occurrence of oospores (sexual stage), 88 Phytophthora infestans populations were investigated. The populations were collected in 14 regions of Russia. In total, 3677 samples have been checked: 2888--from potato leaflets (55 populations), 344--from tomato leaflets (16 populations), 445--from tomato fruits (17 populations). The oospores have been detected both in potato and tomato leaflets and in fruits with different occurrence--4.4%, 11.9%, and 28.8%. Occurrence of oospores per sample was also maximal in tomato fruits. After overwintering a majority of oospores (50-90%) kept their viability. Sometimes, loss of viability of some oospores was caused by the external negative influence. About 25% of oospores formed at crossing between current Russian P. infestans strains were capable to germinate. Treatment with negative temperature (-12 degrees C) or Trichoderma suspension increased percentage of germinated oospores. In some field trials, the oospores caused affection of quite many of potato plants. However, in other trials only particular plants or no plants were affected. Tomato germlings were affected only under unfavourable conditions.
Assuntos
Phytophthora infestans/fisiologia , Phytophthora infestans/patogenicidade , Doenças das Plantas/microbiologia , Esporos Fúngicos/crescimento & desenvolvimento , Germinação , Solanum lycopersicum/microbiologia , Folhas de Planta/microbiologia , Prevalência , Federação Russa , Solanum tuberosum/microbiologiaRESUMO
The mucous layer that covers the intestinal absorptive surface acts as a barrier against bacterial translocation. The chicken gut contains a diverse bacterial population which interacts with the mucous layer. In this report, we studied the effect of changing the intestinal microbial populations on mucin dynamics by feeding 1-d-old chicks a control diet or that diet containing either antibiotic growth promoter (AGP) or a probiotic product for 14 d. Dietary AGP increased the proportions of Bifidobacterium species in the duodenum compared with the other groups. In AGP-fed chicks, the villous surface area was increased in the jejunum, goblet cell density was greater in the jejunum and ileum, and mucin glycoprotein levels in the duodenum were lower than in the other groups (P < 0.05). Feeding AGP increased the expression of mucin mRNA in the jejunum and ileum compared with controls. The dietary probiotic increased the proportion of Lactobacillus species in the ileum compared with the controls (P < 0.05) and significantly enlarged the goblet cell "cup" area throughout the small intestine compared with the other groups. Expression of mucin mRNA and the levels of mucin glycoprotein were greater in the jejunum of the probiotic-fed chicks compared with controls (P < 0.05). Neither the probiotic nor AGP treatments affected the thickness of the mucous adherent layer. These results indicate that both probiotic and AGP altered processes of mucin biosynthesis and/or degradation mediated via changes in the intestinal bacterial populations. These modifications in mucin dynamics influence gut function and health and may change nutrient uptake.
Assuntos
Antibacterianos/farmacologia , Dieta , Intestino Delgado/microbiologia , Intestino Delgado/fisiologia , Mucinas/metabolismo , Ração Animal , Animais , Antibacterianos/administração & dosagem , Bifidobacterium/efeitos dos fármacos , Bifidobacterium/crescimento & desenvolvimento , Galinhas , Primers do DNA , DNA Bacteriano/genética , DNA Bacteriano/isolamento & purificação , Suplementos Nutricionais , Enterococcus faecium/efeitos dos fármacos , Enterococcus faecium/crescimento & desenvolvimento , Feminino , Genoma Bacteriano , Crescimento/efeitos dos fármacos , Mucosa Intestinal/efeitos dos fármacos , Mucosa Intestinal/microbiologia , Mucosa Intestinal/fisiologia , Intestino Delgado/efeitos dos fármacos , Lactobacillus/efeitos dos fármacos , Lactobacillus/crescimento & desenvolvimento , Masculino , Reação em Cadeia da Polimerase , ProbióticosRESUMO
The aim of the study was to evaluate the effectiveness of the transdermal electro impulses directed on ganglions stellatum in order to prevent the accelerated ageing and improve the cerebral venous flow. Using by the angioscanning method it was been found the phenomenon of ectasia in venae jugularis int. in patients suffering of accelerated ageing in 100% cases. The normalization of venous diameter after the treatment by electrical impulses has been found in 31-55% of cases.
Assuntos
Senilidade Prematura/prevenção & controle , Veias Cerebrais/inervação , Circulação Cerebrovascular , Gânglio Estrelado/fisiologia , Estresse Psicológico/terapia , Estimulação Elétrica Nervosa Transcutânea , Adulto , Velocidade do Fluxo Sanguíneo/fisiologia , Pressão Sanguínea/fisiologia , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
Seven-year experience in the treatment of 21 patients with chronic osteomyelitis of the ribs and sternum is summarized. Great omentum was used as plastic and disinfecting material in combination with laser radiation. Indications, techniques, short- and long-term results are presented. There were no recurrences of purulent process in the bones. Omentoplasty is the method of choice in surgical treatment of purulent lesions of costal cartilage and sternum.
Assuntos
Omento/transplante , Osteomielite/cirurgia , Costelas/cirurgia , Esterno/cirurgia , Cartilagem/cirurgia , Doença Crônica , Humanos , Terapia com Luz de Baixa Intensidade , Osteomielite/radioterapia , Estudos Retrospectivos , Resultado do TratamentoRESUMO
The analysis of antiosteoporotic efficacy of alphacalcidol was made in 50 patients with rheumatoid arthritis (RA). 30 RA patients received alphacalcidol in a dose 0.75-1.0 mcg/day for 12 months. 20 control RA patients did not receive the drug. Mineral density of the bone tissue (MD) of the proximal femur and low back spine was studied using double x-ray absorptiometry at the start of the treatment and 12 months after it. It was established that alphacalcidol stabilizes MD of the neck of the femur and low spine. A significant MD increase was observed in those areas of the proximal femur where cortical bone tissue prevails.
Assuntos
Adjuvantes Imunológicos/uso terapêutico , Artrite Reumatoide/tratamento farmacológico , Densidade Óssea/fisiologia , Hidroxicolecalciferóis/uso terapêutico , Adjuvantes Imunológicos/administração & dosagem , Artrite Reumatoide/complicações , Artrite Reumatoide/diagnóstico , Feminino , Fêmur/patologia , Humanos , Hidroxicolecalciferóis/administração & dosagem , Pessoa de Meia-Idade , Osteoporose/diagnóstico , Osteoporose/tratamento farmacológico , Osteoporose/etiologia , Índice de Gravidade de DoençaRESUMO
In a rabbit model of Streptococcus pneumoniae meningitis single doses of 10 and 2.5 mg of the glycopeptide LY333328 per kg of body weight reduced bacterial titers in cerebrospinal fluid (CSF) almost as rapidly as ceftriaxone at 10 mg/kg/h (changes in log CFU, -0.29 +/- 0.21 and -0.26 +/- 0.22 versus -0.34 +/- 0.15/ml/h). A dose of 1 mg/kg was bacteriostatic (change in log CFU, 0.01 +/- 0.11/ml/h). In two animals receiving LY333328 at a dose of 40 mg/kg the bacterial titers were reduced by 0.54 and 0.51 log CFU/ml/h. The penetration of CSF by LY333328 was 1 to 5%. The concentrations of lipoteichoic and teichoic acids in CSF and neuronal damage were similar in ceftriaxone- and LY333328-treated animals.
Assuntos
Antibacterianos/uso terapêutico , Glicopeptídeos , Meningite Pneumocócica/tratamento farmacológico , Streptococcus pneumoniae , Animais , Antibacterianos/farmacocinética , Apoptose , Área Sob a Curva , Líquido Cefalorraquidiano/efeitos dos fármacos , Líquido Cefalorraquidiano/microbiologia , Contagem de Colônia Microbiana , Modelos Animais de Doenças , Lipoglicopeptídeos , Meningite Pneumocócica/metabolismo , Testes de Sensibilidade Microbiana , Neurônios/efeitos dos fármacos , Neurônios/patologia , Penicilinas/farmacologia , Coelhos , Streptococcus pneumoniae/efeitos dos fármacos , Resultado do TratamentoRESUMO
Indirect immunoperoxidase technique in combination with cytophotometry showed that prolactin imbalance in the periovulatory period is characterized by considerable changes in the expression of prolactin receptors in uterine glands and endometrial stroma (but not in the myometrium) and in the pituitary gland and hypothalamus, while receptor compartmentalization pattern remains unchanged.
Assuntos
Hipotálamo/metabolismo , Ovulação , Hipófise/metabolismo , Prolactina/farmacologia , Receptores da Prolactina/metabolismo , Útero/metabolismo , Animais , Bromocriptina/farmacologia , Citofotometria , Estradiol/sangue , Feminino , Antagonistas de Hormônios/farmacologia , Hipotálamo/efeitos dos fármacos , Folículo Ovariano/efeitos dos fármacos , Folículo Ovariano/metabolismo , Hipófise/efeitos dos fármacos , Progesterona/sangue , Prolactina/sangue , Ratos , Receptores da Prolactina/genética , Útero/citologia , Útero/efeitos dos fármacosRESUMO
Clinico-experimental investigations of Vitaflon in cardiosurgery of growing organism have shown that Vitaflon is a firm, plastic and good material for patches of different size and form, has high thrombus resistance. Inflammatory alterations in the surrounding tissues were not pronounced. The ingrowth of the connective tissue elements into the pores of the patch and its endothelialization were noted. Since 1996 the material has been used as patches in surgical correction of congenital heart diseases. The follow-up of the patients during 4 years failed to find symptoms of recanalization, thrombotic and infectious complications. Vitaflon can be widely used as a plastic material in cardiosurgery for congenital heart diseases.
Assuntos
Procedimentos Cirúrgicos Cardíacos/métodos , Politetrafluoretileno , Telas Cirúrgicas , Adolescente , Adulto , Animais , Criança , Pré-Escolar , Cães , Avaliação Pré-Clínica de Medicamentos , Seguimentos , Cardiopatias Congênitas/cirurgia , Humanos , Masculino , Miocárdio/patologia , Técnicas de Sutura , Fatores de TempoRESUMO
In a rabbit model of Streptococcus pneumoniae meningitis, 5 mg of gemifloxacin mesylate (SB-265805) per kg/h reduced the bacterial titers in cerebrospinal fluid (CSF) almost as rapidly as 10 mg of ceftriaxone per kg/h (Deltalog CFU/ml/h +/- standard deviation [SD], -0.25 +/- 0.09 versus -0.38 +/- 0.11; serum and CSF concentrations of gemifloxacin were 2.1 +/- 1.4 mg/liter and 0.59 +/- 0.38 mg/liter, respectively, at 24 h). Coadministration of 1 mg of dexamethasone per kg did not affect gemifloxacin serum and CSF levels (2.7 +/- 1.4 mg/liter and 0.75 +/- 0.34 mg/liter, respectively, at 24 h) or activity (Deltalog CFU/ml/h +/- SD, -0.26 +/- 0.11).
Assuntos
Anti-Infecciosos/uso terapêutico , Fluoroquinolonas , Meningite Pneumocócica/tratamento farmacológico , Naftiridinas/uso terapêutico , Animais , Anti-Infecciosos/farmacocinética , Ceftriaxona/uso terapêutico , Cefalosporinas/uso terapêutico , Líquido Cefalorraquidiano/imunologia , Líquido Cefalorraquidiano/microbiologia , Modelos Animais de Doenças , Gemifloxacina , Hipocampo/patologia , Meningite Pneumocócica/microbiologia , Meningite Pneumocócica/patologia , Testes de Sensibilidade Microbiana , Naftiridinas/farmacocinética , Neurônios/patologia , Coelhos , Streptococcus pneumoniae/isolamento & purificaçãoRESUMO
Experiments were conducted on rats to study the antioxidant effects of amtisol and trimethasidin (25 mg/kg) in incomplete cerebral ischemia complicated by hypoxia. Amtisol as well as trimethasidin inhibited activation of lipid peroxidation (LPO) and prevented decrease in activity of the antioxidant system. In in vitro experiments amtisol and trimethasidin blocked epinephrine auto-oxidation. Amtisol inhibited ascorbate-dependent LPO in the liposomes and metabolizing model system, inhibited fermentative NADP-dependent POL in brain tissue homogenates.