RESUMO
Smart assemblies have attracted increased interest in various areas, especially in developing novel stimuli-responsive theranostics. Herein, commercially available, natural tannic acid (TA) and iron oxide nanoparticles (Fe3 O4 NPs) are utilized as models to construct smart magnetic assemblies based on polyphenol-inspired NPs-phenolic self-assembly between NPs and TA. Interestingly, the magnetic assemblies can be specially disassembled by adenosine triphosphate, which shows a stronger affinity to Fe3 O4 NPs than that of TA and partly replaces the surface coordinated TA. The disassembly can further be facilitated by the acidic environment hence causing the remarkable change of the transverse relaxivity and potent "turn-on" of fluorescence (FL) signals. Therefore, the assemblies for specific and sensitive tumor magnetic resonance and FL dual-modal imaging and photothermal therapy after intravenous injection of the assemblies are successfully employed. This work not only provides understandings on the self-assembly between NPs and polyphenols, but also will open new insights for facilely constructing versatile assemblies and extending their biomedical applications.
Assuntos
Trifosfato de Adenosina/química , Hipertermia Induzida , Imageamento por Ressonância Magnética , Neoplasias/terapia , Imagem Óptica , Fototerapia , Polifenóis/fisiologia , Animais , Difusão Dinâmica da Luz , Fluorescência , Células Hep G2 , Humanos , Concentração de Íons de Hidrogênio , Raios Infravermelhos , Camundongos , Neoplasias/patologia , SoluçõesRESUMO
Theranostic nanomedicines that integrate diagnostic and therapeutic moieties into a single nanoscale platform are playing an increasingly important role in fighting cancer. Here, a facile and green synthetic strategy for hollow CoPt alloy nanoparticles (HCPA-NPs) using plant polyphenols as assisted agents is reported for the first time. This novel strategy enables size-controlled synthesis of HCPA-NPs through the control of the molecular sizes of polyphenols. It is also a versatile strategy for synthesizing other hollow alloy nanoparticles with various metal compositions due to the diverse metal-chelating ability of the polyphenols. Further studies show that HCPA-NPs have good biocompatibility and can be successfully implemented for magnetic resonance and photoacoustic dual-modal imaging guided photothermal therapy. This work brings new insights for the green synthesis of hollow nanoparticles and extends these biocompatible nanoparticles for theranostic applications.
Assuntos
Ligas/química , Química Verde/métodos , Hipertermia Induzida , Nanopartículas Metálicas/química , Imagem Multimodal , Fototerapia , Polifenóis/química , Animais , Sobrevivência Celular , Células HeLa , Células Hep G2 , Humanos , Células MCF-7 , Imageamento por Ressonância Magnética , Nanopartículas Metálicas/ultraestrutura , Camundongos , Polietilenoglicóis/química , Taninos/químicaRESUMO
A new theranostic platform is developed based on biocompatible poly(acrylic acid) (PAA)-Co9 Se8 nanoplates. These PAA-Co9 Se8 nanoplates are successfully utilized for photoacoustic imaging (PAI)/magnetic resonance imaging (MRI) dual-modal imaging. Moreover, the PAA-Co9 Se8 -DOX shows pH-responsive chemotherapy and enables the combination of photothermal therapy and chemotherapy to receive superior antitumor efficacy. This work promises further exploration of 2D nanoplatforms for theranostic applications.
Assuntos
Cobalto , Imageamento por Ressonância Magnética/instrumentação , Nanoestruturas , Técnicas Fotoacústicas/instrumentação , Compostos de Selênio , Nanomedicina Teranóstica/instrumentação , Resinas Acrílicas/síntese química , Resinas Acrílicas/química , Antineoplásicos/administração & dosagem , Materiais Biocompatíveis/síntese química , Materiais Biocompatíveis/química , Sobrevivência Celular/efeitos dos fármacos , Sobrevivência Celular/efeitos da radiação , Cobalto/química , Terapia Combinada/instrumentação , Terapia Combinada/métodos , Meios de Contraste/síntese química , Meios de Contraste/química , Células Hep G2 , Humanos , Concentração de Íons de Hidrogênio , Imageamento por Ressonância Magnética/métodos , Teste de Materiais , Imagem Multimodal/instrumentação , Imagem Multimodal/métodos , Nanoestruturas/química , Transplante de Neoplasias , Técnicas Fotoacústicas/métodos , Fototerapia/instrumentação , Fototerapia/métodos , Compostos de Selênio/síntese química , Compostos de Selênio/química , Nanomedicina Teranóstica/métodosRESUMO
Employing theranostic nanoparticles, which combine both therapeutic and diagnostic capabilities in one dose, has promise to propel the biomedical field toward personalized medicine. Here we investigate the theranostic properties of topological insulator bismuth selenide (Bi2Se3) in in vivo and in vitro system for the first time. We show that Bi2Se3 nanoplates can absorb near-infrared (NIR) laser light and effectively convert laser energy into heat. Such photothermal conversion property may be due to the unique physical properties of topological insulators. Furthermore, localized and irreversible photothermal ablation of tumors in the mouse model is successfully achieved by using Bi2Se3 nanoplates and NIR laser irradiation. In addition, we also demonstrate that Bi2Se3 nanoplates exhibit strong X-ray attenuation and can be utilized for enhanced X-ray computed tomography imaging of tumor tissue in vivo. This study highlights Bi2Se3 nanoplates could serve as a promising platform for cancer diagnosis and therapy.