RESUMO
Pharmacological and metabolic effects of Galleria mellonella larvae extract used in Russian folk medicine to treat cardiovascular and senile diseases were studied. It was shown that the extract possesses adaptogenic, cardiotropic, cardioprotective, and hypocoagulant properties. The extract possesses low toxicity and does not cause significant changes in biochemical parameters in the blood serum of laboratory animals. Increase in catecholamine content in the heart and aortic tissues and their decrease in adrenal glands are unfavourable effects of high doses of the extract.
Assuntos
Adaptação Fisiológica/efeitos dos fármacos , Cardiopatias/prevenção & controle , Mariposas/metabolismo , Extratos de Tecidos/farmacologia , Animais , Anuros , Coagulação Sanguínea/efeitos dos fármacos , Epinefrina/metabolismo , Glicogênio/metabolismo , Coração/efeitos dos fármacos , Cardiopatias/induzido quimicamente , Cardiopatias/fisiopatologia , Técnicas In Vitro , Testes de Função Renal , Músculo Liso Vascular/efeitos dos fármacos , Músculo Liso Vascular/metabolismo , Miocárdio/metabolismo , Norepinefrina/metabolismo , Tamanho do Órgão/efeitos dos fármacos , Resistência Física/efeitos dos fármacos , Ratos , Estrofantinas/antagonistas & inibidores , Estrofantinas/toxicidadeRESUMO
1. The action of the extract from larvae of the great wax moth Galleria mellonella L. used in Russian folk medicine was studied. 2. Two active components influencing the growth and morphological differentiation of cells in vitro were found. 3. The presence of these components in the extract was conditioned by consumption of honeybee products by Galleria mellonella larvae. 4. Cytotoxicity of honeybee products was studied.