[Morphological basis of the effect of hypothalamic neurosecretion on structural and functional homeostasis of pro- and eukaryotes].

Experimental histological aspects of neuroendocrinology are examined together with the emphasis on the regulatory and adaptogenic role of hypothalamic nonapeptidergic neurosecretory system in provision of structural-functional homeostasis in animal organism, including the conditions of its interaction with the microorganisms. Some new facts are presented demonstrating the positive effect of oxytocin on the realization of histo- and organotypical potencies by the tissues with different cambial characteristics during the necrotic suppurative processes. The priority directions are indicated for the further development of the fundamental and applied aspects of neuroendocrinology for optimization of the reparative histogeneses and inactivation of bacterial persistence potential.

Hypothalamic nonapeptidergic regulation of cell and tissue homeostasis: interactions of pro- and eukaryotes.

Data on the structural-functional organization of the hypothalamic nonapeptidergic neurosecretory system in mammals and its role in regulating the adaptive reactions of animals are presented; reports describing the biological features of interactions between pro- and eukaryotes in in situ conditions and on cultivation and in experimental pathology are summarized. Morphofunctional criteria are established on the basis of contemporary morphological approaches to allow effective evaluation of the range of histoblastic and organotypic potentials of the visceral organs and their compensatory-adaptive capacities realized under hypothalamic neuroendocrine control and seen on interactions with bacterial pathogens. Emphasis is placed on experimental histological grounds for new methods for the complex treatment of wound and purulent-necrotic processes, including the use of hypothalamic nonapeptides (oxytocin).

[Hypothalamic nonapeptidergic control of cell and tissue homeostasis, pro- and eukaryotes interactions].

The data on the structural and functional organization of mammalian hypothalamic nonapeptidergic neurosecretory system and its role in the control of the animal adaptive reactions, are presented. New findings demonstrating the biologic regularities of pro- and eukaryote interactions in situ as well as in culture and in experimental pathology, are summarized. On the basis of modem morphological approaches, significant morphofunctional criteria are established, which permit to efficiently evaluate the range of histoblastic and organotypic potentialities of the visceral organs and their compensatory-adaptive properties, realized under the hypothalamic neroendocrine control and observed during the interactions with bacterial pathogens. The important place is given to experimental histological substantiation of the new methods of complex treatment of the wounds and pyo-necrotic processes, including those employing hypothalamic nonapeptides (oxytocin).

[Endocytosymbiosis of microorganisms in mammal eukaryotic cells and factors of its regulation].

Morphofunctional equivalents of the process of long-term intracellular prokaryotes--eukaryotes interaction were studied by light and electron microscopy. The mechanisms for adaptation, elaborated in the course of evolution of bacteria-host interaction, were analysed on the ultrastructural level. A concept on the role of hypothalamic nonapeptides, as factors of regulation of intracellular persistence and symbiosis of prokaryotes, is discussed.

[Fundamental and applied aspects of neuroendocrine regulation of pro- and eukaryote interactions]. / Fundamental'ye i prikladnye aspekty neiroéndokrinnoi reguliatsii vzaimodeistviia pro- i éukariot.

The paper presents the results of light, atomic-force, and electron microscopic studies of prokaryotes (various Staphylococcus aureus strains) and eukaryotes (Rat digestive and respiratory cells and tissues) in in vivo and in vivo interactions. It is concluded that hypothalamic nonapeptides play a modulating role in the persistence and symbiotic relations in the bacterium-host system and regulate cellular and tissue homeostasis through reparative histogenesis.

[Effect of neuroendocrine factors on reparation histogenesis of the pancreas during cultivation in the body]. / Vliianie neiroéndokrinnykh faktorov na reparativnyi gistogenez podzheludochnoi zhelezy pri kul'tivirovanii v organizme.

Morphofunctional changes of the pancreas were studied in adult male rats after cultivation by Lazarenko method and in diffusion chambers. The implants were examined on post cultivation d 1,3,6,8,10. The implantation of the pancreatic tissues with hypothalamic neuropeptidergic (supra optic) nuclei was also performed using light and electron microscopy and histochemistry. Hypothalamic neuropeptide (oxytocin and vasopressin) were stated to be interlevel regulatory factors of proliferation, growth and cytodifferentiation of the epithelium and connective tissue cells of the pancreas. Hypothalamic neurohormones influence the maintenance of secretory epithelium viability.

[Role of hypothalamic nonapeptides in interaction of prokaryotic and eukaryotic cells]. / Rol' gipotalamicheskikh nonapeptidov vo vzaimodeistvii pro- i éukarioticheskikh kletok.

The role of hypothalamic nonapeptides in the interaction of prokaryotic and eukaryotic cells was studied in the experimental setting. Nonapeptides were found to stimulate the adaptive and regenerative properties of eukaryotic cells and they are likely to have an antimicrobic effect on prokaryotic ones. The paper discusses the modulating role of nonapeptides in the establishment of symbiotic relations in the bacterial agent-host system.

[The neurobiological aspects of the regulation of reparative histogenesis]. / Neirobiologicheskie aspekty reguliatsii reparativnykh gistogenezov.

In mature male rabbits and outbred male rats (body weight 180-280 g) the implantation of the different tissues (adenohypophysis, ventricular myocardium, pharyngeal and bronchial epithelium) with hypothalamic nonapeptidergic nuclei in vivo and in vitro was performed by means of light microscopy, histochemistry, immunocytochemistry, histoautoradiographic (3H Thymidine) and electron microscopy methodics. It is demonstrated that hypothalamic nonapeptides (oxytocin and vasopressin) and monoamines are the interlevel regulatory factors of the proliferation, growth and cytodifferentiation of the different genesis tissues. Their role in realization by tissues of histo- and organotypic potentiality adaptive properties and adequate intercellular correlations in appropriate histotypes is indicated.

[Effect of miliacin oil on healing of trophic ulcers]. / Vliianie miliatsinovogo masla na zazhivlenie troficheskikh iazv.

The effects of miliaceum oil used for tropical application to trophic ulcer were studied for the first time. The oil was obtained from millet processing waste products. Experiments on 73 rats with induced trophic ulcers demonstrated that the agent under study had a marked antiinflammatory effect and substantially activated reparative processes. The period of trophic ulcer healing was reduced by 12-16 days with the milliaceum oil as compared with oleum Hippophae and oleum Rosae.

[The effect of hypothalamic factors on the proliferation and cell differentiation of adenohypophyseal glandular epithelium implanted into the anterior chamber of the eye]. / Vliianie gipotalamicheskikh faktorov na proliferatsiiu i tsitodifferentsirovku zhelezistogo épiteliia adenogipofiza pri implantatsii v peredniuiu kameru glaza.

The purpose was to determine the effect of a complex of factors of large cell (supraoptic, paraventricular) or small cell (arcuate) hypothalamic nuclei on adenohypophyseal proliferation and cytodifferentiation, manifested in body tissue culture. Experiments were staged on 80 hypophysectomized random bred albino male rats with a body mass of 200-230 g. The evaluation of cell types of adenocytes was performed at stages of implantation every 12h-26 days with the help of light optic, electron microscopic, histoautoradiographic, immunohistochemical and radioimmunoassay methods. Supraoptic and paraventricular nuclei were shown to provide for the stimulation of adenocytic proliferation. The factors of paraventricular nuclei enhanced secretion in somato-, mammo-, thyro- and corticotropocytes and created conditions for their secondary cytodifferentiation.