1.
Bioorg Med Chem Lett
; 29(1): 36-39, 2019 01 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30455147
RESUMO
Here we present a virtual docking screen of 1648 commercially available covalent fragments, and identified covalent inhibitors of cysteine protease cathepsin L. These inhibitors did not inhibit closely related protease cathepsin B. Thus, we have established virtual docking of covalent fragments as an approach to discover covalent enzyme inhibitors.