RESUMO
The therapeutic efficacy of enterocin S760, a broad spectrum antimicrobial peptide produced by Enterococcus faecium LWP760 was tested on mice infected with Bacillus anthracis M-71 to induce anthrax (second Tsenkovsky's vaccine). Intraperitoneal four-, two- or one-fold administration of the peptide in a dose of 25 mg/kg for 10 days for prophylactic (1 hour after the contamination) and therapeutic (24 hours after the contamination) purposes prevented or cured the infection in 90-100% of the mice versus the 100-percent lethality in the control (untreated animals). The antimicrobial activity of enterocin S760 against B. anthracis M-71 in vivo correlated with activity in vitro. Enterocin S760 is considered a novel promising antimicrobial for the treatment of grampositive and gramnegative infections.
Assuntos
Antraz/tratamento farmacológico , Antibacterianos/administração & dosagem , Bacillus anthracis/efeitos dos fármacos , Bacteriocinas/administração & dosagem , Animais , Antibacterianos/isolamento & purificação , Bacteriocinas/isolamento & purificação , Modelos Animais de Doenças , Avaliação Pré-Clínica de Medicamentos , Enterococcus faecium/química , CamundongosRESUMO
The time course of the clinical, biochemical and serological indices was studied during the treatment of malleus in monkeys. The internal organs of the animals infected with Pseudomonas mallei were investigated pathomorphologically. The efficacy of the biseptol/oxalinic acid combination in the therapy of malleus was estimated.