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Best Pract Res Clin Endocrinol Metab ; 34(1): 101377, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-32081544

RESUMO

Many papers evaluated the effect of the environmental, or occupational endocrine disruptors (ED), on the thyroid gland, that can lead to thyroid autoimmunity. A higher prevalence of autoimmune thyroid diseases (AITD) was observed in people living in polluted areas near to petrochemical plants, and in petrochemical workers, but also in area contaminated with organochlorine pesticides, or with polychlorinated biphenyls, or near aluminum foundries. The exposure to Hg in chloralkali workers, or in swordfish consumers has been also found to increase AITD prevalence. Vanadium has been shown to increase the inflammatory response of thyrocytes. A beneficial effect of omega-3 fatty acids, and of myo-inositol and selenomethionine have been shown to counteract the appearance of AITD in subjects exposed to environmental or occupational ED. More large studies are needed to investigate the potential roles of ED in the induction of AITD, and of agents or habits that are able to prevent them.


Assuntos
Autoimunidade/efeitos dos fármacos , Disruptores Endócrinos/farmacologia , Glândula Tireoide/efeitos dos fármacos , Glândula Tireoide/imunologia , Tireoidite Autoimune/etiologia , Disruptores Endócrinos/toxicidade , Exposição Ambiental/efeitos adversos , Exposição Ambiental/prevenção & controle , Ácidos Graxos Ômega-3/uso terapêutico , Humanos , Inositol/uso terapêutico , Exposição Ocupacional/efeitos adversos , Exposição Ocupacional/prevenção & controle , Fatores de Risco , Selenometionina/uso terapêutico , Tireoidite Autoimune/epidemiologia , Tireoidite Autoimune/prevenção & controle , Vanádio/farmacologia
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