RESUMO
Eucalyptin A (1), together with two known compounds 2 and 3 exhibiting potent inhibition on HGF/c-Met axis, was discovered from the fruits of Eucalyptus globulus. 1 possessed an unprecedented carbon framework of phloroglucinol-coupled sesquiterpenoid, and its structure was elucidated by spectroscopic method and ECD calculation. A brief structure-activity relationship discussion indicated that the coupling of a phloroglucinol and a sesquiterpenoid is essential for the activity.
Assuntos
Eucalyptus/química , Fator de Crescimento de Hepatócito/antagonistas & inibidores , Floroglucinol/química , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Proteínas Proto-Oncogênicas c-met/antagonistas & inibidores , Sesquiterpenos/química , Animais , Movimento Celular/efeitos dos fármacos , Proliferação de Células/efeitos dos fármacos , Cães , Fator de Crescimento de Hepatócito/farmacologia , Humanos , Células Madin Darby de Rim Canino , Inibidores de Proteínas Quinases/química , Inibidores de Proteínas Quinases/farmacologia , Relação Estrutura-Atividade , Ativador de Plasminogênio Tipo Uroquinase/antagonistas & inibidoresRESUMO
Ten limonoids, toonacilianins A-J, and two norlimonoids, toonacilianins K and L, together with seven known compounds were isolated from the stems of Toona ciliata var. henryi (Meliaceae). Their structures were elucidated by spectroscopic analysis. Two compounds showed strong cytotoxic activities.
Assuntos
Antineoplásicos Fitogênicos/uso terapêutico , Limoninas/uso terapêutico , Meliaceae/química , Neoplasias/tratamento farmacológico , Fitoterapia , Adenocarcinoma/tratamento farmacológico , Antineoplásicos Fitogênicos/isolamento & purificação , Antineoplásicos Fitogênicos/farmacologia , Linhagem Celular Tumoral , Humanos , Leucemia Mieloide/tratamento farmacológico , Limoninas/isolamento & purificação , Limoninas/farmacologia , Neoplasias Pulmonares/tratamento farmacológico , Estrutura Molecular , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Extratos Vegetais/uso terapêutico , Caules de Planta/químicaRESUMO
Four new sesquiterpenoids, chlomultins A-D (1-4), were isolated from the whole plant of Chloranthus multistachys. Their structures were established on the basis of spectroscopic analysis.
Assuntos
Medicamentos de Ervas Chinesas/isolamento & purificação , Magnoliopsida/química , Sesquiterpenos/isolamento & purificação , Medicamentos de Ervas Chinesas/química , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Sesquiterpenos/químicaRESUMO
Two new sesquiterpenes, sarcandralactones A (1) and B (2), and five new dimeric sesquiterpenoids, sarcandrolides A-E (3-7), along with 10 known compounds were isolated from the whole plants of Sarcandra glabra. Their structures were elucidated on the basis of spectroscopic analysis. Some of the new isolates exhibit significant cytotoxicities when tested against a small panel of tumor cell lines.