RESUMO
Furanodiene is a sesquiterpene extracted from the essential oil of the rhizome of Curcuma wenyujin Y.H. Chen et C. Ling (Wen Ezhu). Furanodiene is the primary component in Wen Ezhu's essential oil, accounting for more than 20% by weight. In vitro, MTT assay was used to compare the inhibitory effects of furanodiene and Wen Ezhu's essential oil on 11 human cancer cell lines. Compared to the essential oil, furanodiene showed stronger growth inhibitions on Hela, Hep-2, HL-60, PC3, SGC-7901 and HT-1080 cells with IC(50) between 0.6-4.8 microg/ml. In vivo, furanodiene was also found to exhibit inhibitory effects on the growth of uterine cervical (U14) and sarcoma 180 (Sl80) tumors in mice. Our data suggests that furanodiene, an active component from the essential oil of Wen Ezhu, possesses efficacy against uterine cervical cancer.
Assuntos
Curcuma , Medicamentos de Ervas Chinesas/farmacologia , Furanos/farmacologia , Compostos Heterocíclicos com 2 Anéis/farmacologia , Sesquiterpenos/farmacologia , Neoplasias do Colo do Útero/tratamento farmacológico , Adenocarcinoma , Animais , Neoplasias da Mama , Carcinoma Hepatocelular , Divisão Celular/efeitos dos fármacos , Feminino , Fibrossarcoma/tratamento farmacológico , Fibrossarcoma/patologia , Células HL-60 , Células HeLa , Humanos , Células K562 , Leucemia , Neoplasias Hepáticas , Neoplasias Pulmonares , Camundongos , Camundongos Endogâmicos , Tamanho do Órgão , Baço/patologia , Timo/patologia , Neoplasias do Colo do Útero/patologia , Ensaios Antitumorais Modelo de XenoenxertoRESUMO
The volatile constituents of Guanxin Suhe Wan and its ingredient drugs were analyzed by gas chromatography-mass spectrometry. Two compounds, borneol and benzyl benzoate were determined by selected ion monitoring with methyl salicylate as the internal standard. The recoveries of borneol and benzyl benzoate were 91.7% and 89.7% with the RSDs of 5.6% and 2.3%, respectively.