1.
Bioorg Med Chem Lett
; 16(20): 5275-9, 2006 Oct 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16919453
RESUMO
Structure-activity relationships of a 4-aminoquinoline MCH1R antagonist lead series were explored by synthesis of analogs with modifications at the 2-, 4-, and 6-positions of the original HTS hit. Improvements to the original screening lead included lipophilic groups at the 2-position and biphenyl, cyclohexyl phenyl, and hydrocinnamyl carboxamides at the 6-position. Modifications of the 4-amino group were not well tolerated.