1.
Chem Commun (Camb)
; 58(96): 13329-13332, 2022 Dec 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36373630
RESUMO
A tumor-targeting therapy strategy is urgently needed to increase the accumulation of drugs in tumors and reduce the side effects in normal tissues. Herein, we developed an esterase-activatable curcumin prodrug Cur-RGD for tumor-targeting therapy. Armed with the tumor-targeting RGD peptide and in situ esterase-triggered drug release, this prodrug Cur-RGD can efficiently improve the therapeutic effect of curcumin in tumors.