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1.
Front Endocrinol (Lausanne) ; 12: 771641, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34880833

RESUMO

Background: Chlordecone is an endocrine-disrupting chemical with well recognized estrogenic and progestagenic properties. This organochlorine insecticide was extensively used in the French West Indies from 1973 to 1993 to control the banana root borer. Due to its poor degradation in the environment, permanently polluted soil is responsible for the current contamination of the food chain and human beings. We aimed to examine the relationship of in utero exposure to chlordecone and thyroid (thyroid stimulating hormone [TSH], free tri-iodothyronine [FT3], free thyroxine [FT4]), metabolic (insulin growth-factor 1, leptin, adiponectin), and sex-steroid (dehydroepiandrosterone [DHEA], total testosterone [TT], dihydrotestosterone [DHT], estradiol [E2]) hormone levels in children at the age of seven years who participated in TIMOUN, an ongoing birth cohort in Guadeloupe. Methods: Chlordecone concentrations were measured in cord-blood at delivery. Thyroid, metabolic, and sex-steroid hormone levels were determined in the blood of children at seven years of age. Associations between in utero chlordecone exposure and hormone levels at seven years of age were assessed by multiple linear or logistic regression, controlling for confounding factors. Results: Among the study population (210 boys and 228 girls), chlordecone and hormone measurements were available for 124 boys and 161 girls. We found the third quartile of in utero chlordecone exposure relative to the lowest quartile to be associated with elevated TSH levels in girls and elevated DHEA, TT, and DHT levels in both sexes. Complementary non-linear analysis (spline regression) confirmed a significant non-linear trend for TSH in girls and DHEA and DHT in boys. Conclusion: In utero chlordecone exposure was associated with elevated levels of selected thyroid (TSH) and sex-steroid (DHEA, TT, and DHT) hormones at seven years in a non-monotonic dose response (inverted U) relationship. The implications for future health and reproductive function in puberty and adulthood should be determined.


Assuntos
Clordecona/toxicidade , Exposição Ambiental , Inseticidas/toxicidade , Efeitos Tardios da Exposição Pré-Natal/sangue , Glândula Tireoide/efeitos dos fármacos , Adiponectina/sangue , Criança , Desidroepiandrosterona/sangue , Di-Hidrotestosterona/sangue , Estradiol/sangue , Feminino , Humanos , Fator de Crescimento Insulin-Like I/metabolismo , Leptina/sangue , Masculino , Gravidez , Testosterona/sangue , Tireotropina/sangue , Tiroxina/sangue , Tri-Iodotironina/sangue
2.
Chemosphere ; 193: 100-107, 2018 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-29127834

RESUMO

Sixteen weaned male Alpine kids (Capra hircus) were subjected to a 21-day oral daily exposure of 0.05 mg kg-1 BW. d-1 of chlordecone (CLD) and 0.30 µg kg-1 BW. d-1 of each non-dioxin-like polychlorinated biphenyls (NDL-PCBs, congeners 28, 52, 101, 138, 153 and 180). Four kids, identified as the CONTA group, were slaughtered at the end of the exposure, while the remaining animals (n = 12) were fed with specific diets for an additional 21-day decontamination period before slaughtering. Kids from the DECONTA (n = 4) group were fed a control diet, while those from the AC10% and PO8% group received pellets supplemented with 10% activated carbon (AC) and 8% paraffin oil (PO), respectively. CLD and NDL-PCB levels in blood, liver, peri-renal fat and muscles from different groups were analysed to compare the decontamination dynamics of the pollutants and to determine the efficiency of AC and PO to decrease the body levels of pollutants. After the decontamination period, the CLD levels considerably decreased (more than 60%) in blood, liver, muscles and fat. Concerning NDL-PCBs, the decontamination process was much lower. Overall, CLD appeared to be less retained in kids' organism compared with NDL-PCBs, and the decontamination dynamics of these pollutants appeared to be different because of their specific physicochemical properties and lipophilicity. Furthermore, the dietary supplementation with AC or PO did not significantly affect the decontamination dynamics.


Assuntos
Carvão Vegetal/metabolismo , Clordecona/metabolismo , Suplementos Nutricionais , Poluentes Ambientais/metabolismo , Cabras , Óleos/metabolismo , Parafina/metabolismo , Bifenilos Policlorados/metabolismo , Animais , Clordecona/análise , Descontaminação , Dieta , Poluentes Ambientais/análise , Fígado/química , Masculino , Bifenilos Policlorados/análise
3.
Environ Sci Pollut Res Int ; 22(11): 7991-8002, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-24920261

RESUMO

Chlordecone is a persistent organochlorine pesticide widely used between 1972 and 1993 in the French West Indies to control the root borer in banana fields. Chlordecone use resulted in long-term pollution of soils, contamination of waters, of aquatic organisms, and of fields. Chlordecone is known to be neurotoxic, to increase prostate cancer, and to have negative effects on cognitive and motor development during infancy. In Guadeloupe, most of the freshwater species living in contaminated rivers exceed the French legal limit of 20 µg·kg(-1) wet weight. In the present study, we chose a transcriptomic approach to study the cellular effects of chlordecone in the giant freshwater prawn Macrobrachium rosenbergii, an important economical species in Guadeloupe. Quantitative PCR revealed an induction of genes involved in defense mechanism against oxidative stress (catalase and selenium-dependent glutathione peroxidase) in prawns exposed to low environmental concentrations of chlordecone after 12 and 24 h of exposure. In prawns reared in a contaminated farm, transcription of genes involved in the biotransformation process (cytochrome P450 and glutathione-S-transferase (GST)) were induced after 8 days of exposure. Our results provide information on the mechanims of defense induced by chlordecone in aquatic crustacean species. This gene expression study of selected genes should be further strengthened by proteomic analyses and enzymatic activity assays to confirm the response of these biomarkers of stress in crustaceans and to give new insights into the mechanism of toxicity by chlordecone.


Assuntos
Biotransformação/genética , Clordecona/toxicidade , Poluentes Ambientais/toxicidade , Regulação da Expressão Gênica/efeitos dos fármacos , Estresse Oxidativo/efeitos dos fármacos , Palaemonidae/efeitos dos fármacos , Palaemonidae/genética , Animais , Biotransformação/efeitos dos fármacos , Clordecona/análise , Primers do DNA/genética , DNA Complementar/genética , Poluentes Ambientais/análise , Fluorescência , Água Doce , Regulação da Expressão Gênica/fisiologia , Guadalupe , Masculino , Estresse Oxidativo/genética , Reação em Cadeia da Polimerase
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