RESUMO
Many poison control centers partner with public health agencies to handle weekend and after-hours consultations and emergencies. This event describes the effective use of poison control center capabilities in identifying and limiting an outbreak of foodborne botulism. On September 8, 2006, the poison control center received a call regarding a man aged 77 years admitted to a hospital neurology service with dysarthria, dysphagia, and weakness. The poison control center was contacted regarding a concern for botulism. Further information revealed that the patient's wife and a friend had similar symptoms and had eaten together on the previous night. All three sought treatment at different hospitals. The poison control center successfully located the other two patients and provided information regarding the treatment of botulism. In addition, the poison control center notified the on-call local public health official and the CDC for the release of botulinum antitoxin. Public health officials were informed of our concerns for a foodborne outbreak given the common meal. Their investigation determined that the source of botulism was carrot juice.
Assuntos
Antitoxina Botulínica/uso terapêutico , Botulismo/diagnóstico , Daucus carota/microbiologia , Centros de Controle de Intoxicações/organização & administração , Idoso , Bebidas/microbiologia , Toxinas Botulínicas Tipo A/isolamento & purificação , Botulismo/tratamento farmacológico , Botulismo/etiologia , Centers for Disease Control and Prevention, U.S. , Surtos de Doenças/prevenção & controle , Feminino , Contaminação de Alimentos , Humanos , Fatores Imunológicos/uso terapêutico , Masculino , Estados UnidosAssuntos
Suplementos Nutricionais/efeitos adversos , Medicamentos sem Prescrição/efeitos adversos , Selênio/intoxicação , Alopecia/induzido quimicamente , Química Farmacêutica/normas , Diarreia/induzido quimicamente , Suplementos Nutricionais/normas , Feminino , Humanos , Pessoa de Meia-Idade , Unhas/efeitos dos fármacos , Unhas/patologia , Medicamentos sem Prescrição/normasRESUMO
Despite limited scientific evidence, Na2EDTA chelation therapy has been advocated for a variety of conditions including atherosclerosis. Five patients presented with symptoms that developed 30 min-2 h into chelation therapy at an outpatient clinic with infusions of sterile waterwith 3 g Na2EDTA, 2 g MgCl, 100 mg B12, 100 mg B6, 1 ml bit B complex and 15 g Vit C; 1 patient also received 10 ml of 50% DMSO iv. All patients experienced gastrointestinal and musculoskeletal symptoms. Additional effects were (4/5), excessive thirst (4/5), and diaphoresis (4/5). On presentation patients were hypotensive (5/5), tachycardic (4/5) and febrile (5/5). Therapy included iv. fluids (5/5), dopamine (1/5), and ivantibiotics (4/5). Initial data showed leukopenia (5/5), thrombocytopenia (3/5), bandemia (4/5), EKG abnormalities of unknown acuity (5/5), and transient, mild rise in serum creatinine (3/4). All patients were discharged without permanent sequelae. It is unclear if effects were related to dose or rate of administration.