[Protonophoric and uncoupling activity of water-soluble pea flavonols]. / Protonofornaia i razobshchaiushchaia aktivnost' vodorastvorimykh flavonolov gorokha.

In the experiments with artificial lipid membranes and mitochondria the watersoluble pea flavonols are demonstrated to possess weak protonophoric and uncoupling activities which correlate with each other. It is concluded that the mechanism of flavonol uncoupling activity is the same as for classical uncouplers. The results support the earlier suggestion that one of the flavonol functions in the plants may be the regulation of the energetics and metabolism.

[Study of the mechanism of action of fasciolocides using bimolecular phospholipid membranes]. / Issledovanie mekhanizma deistviia fastsiolotsidov s pomoshch'ie bimolekuliarnykh fosfolipidnykh membran

The effects of compounds (see article), where M = -S-, -SO-, -SO2- and of some of their derivatives (18 substances) on electroconductivity of bimolecular lipid membranes (BLM) of different composition in 30 mM tris-HCl (pH 7.5) is studied. The results obtained are compared with literature data concerning fasciolocide and toxic effect of these substances. Certain correlations are found between the action on BLM and biological effects of substances. The analysis of the results allowed a conclusion that the latter are concerned with a discoupling effect of substances on oxidative phosphorylation in mitochondria of helmets and their host. BLM may be applied for evaluating the value of fasciolocide and toxic effects of the substances protonophores.