RESUMO
Allergic contact stomatitis is a rare disorder that is unfamiliar to most clinicians. The vast majority of cases are associated with consumption of products containing cinnamaldehyde or cinnamon essential oil, which are used as flavourings because of their pleasant taste and sensation of freshness. We report here the case of a patient who was diagnosed with alllergic contact stomatitis due to cinnamon-flavoured chewing gum. The clinical features of allergic contact stomatitis, which may occur indiscriminately on any of the oral mucosa, include edema and erythroplakic, ulcerous or hyperkeratotic changes, generally accompanied by a burning sensation. The histopathologic aspect of allergic contact stomatitis is nonspecific but tends to support the clinical diagnosis. Treatment generally consists of eliminating the causal agent. To avoid unnecessary diagnostic procedures and treatments, it is important for clinicians to recognize this disorder to be able to diagnose it quickly and accurately.
Assuntos
Goma de Mascar/efeitos adversos , Cinnamomum zeylanicum/efeitos adversos , Dermatite Alérgica de Contato/complicações , Aromatizantes/efeitos adversos , Hipersensibilidade/complicações , Estomatite/induzido quimicamente , Adulto , Dermatite Alérgica de Contato/patologia , Diagnóstico Diferencial , Feminino , Humanos , Hipersensibilidade/patologia , Úlceras Orais/induzido quimicamente , Úlceras Orais/patologia , Óleos de Plantas/efeitos adversos , Estomatite/patologiaRESUMO
Brevifoliol is a natural diterpene isolated from Taxus baccata Nutt. A series of brevifoliol 1 derivatives, 2-8 and 10, were prepared for characterization and semisynthesis purposes and included the introduction of acetyl, Troc, and TES groups at C-5 and C-13. Derivatives 16-20 of 5-acetylbrevifoliol 2 were obtained via esterification with cinnamic acid, with both 2S-(-)- and 2R-(+)-3-phenyllactic acid, and with N-benzoyl-(2'R,3'S)-3'-phenylisoserine at C-13. Brevifoliol compounds 12, 13, and 15 with either 2S-(-)-phenyllactate moieties at C-5 and C-13 or an N-benzoyl-(2'R,3'S)-3'-phenylisoserinyl at C-13 were also prepared. An abeo-taxane structure for 1 was clearly defined from the (13)C NMR analysis of the 5-acetyl-13-oxo derivative 8 and from the conversion of 1 into 10, a conformationally restrained compound having a C-13, C-15 oxygen bridge. The biological activity of each of these derivatives is being studied.