1.
Bioorg Med Chem Lett
; 10(23): 2683-6, 2000 Dec 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11128651
RESUMO
Metabolites of the COX-2 inhibitor rofecoxib (MK-0966, Vioxx) were prepared by synthetic or biosynthetic methods. Metabolites include products of oxidation, glucuronidation, reduction and hydrolytic ring opening. Based on an in vitro whole blood assay, none of the known human metabolites of rofecoxib inhibits COX-1 nor contributes significantly to the inhibition of COX-2.