1.
Chem Commun (Camb)
; 53(87): 11948-11951, 2017 Oct 31.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29052670
RESUMO
We designed a class of small dimeric cyclic guanidine derivatives which display potent antibacterial activity against both multidrug-resistant Gram-negative and Gram-positive bacteria. They could compromise bacterial membranes without developing resistance, inhibit biofilms formed by E. coli, and exhibit excellent in vivo activity in the MRSA-infected thigh burden mouse model.