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1.
J Nutr Health Aging ; 19(5): 548-54, 2015 May.
Artigo em Inglês | MEDLINE | ID: mdl-25923485

RESUMO

OBJECTIVES: To examine the effect of a dietary supplement containing bilberry extract (BE) on eye fatigue induced by acute video display terminal (VDT) loads. DESIGN AND SETTING: A prospective, randomized, double-blind, placebo-controlled study was performed from August 2012 to February 2013 in the Medical Corporation Jico-kai Yagi Hospital, and the Shinyokohama Shinoharaguchi Orthopedic Surgery and Dermatology Clinic, in Japan. PARTICIPANTS: Two hundred eighty-one office workers aged 20-40 years that used VDTs were screened by critical flicker fusion (CFF) and near point accommodation (NPA). INTERVENTION: The participants were randomized to either a BE (480 mg/day) or placebo (vehicle) group, and took allocated capsule, daily, for 8 weeks. MEASUREMENTS: The CFF, NPA, contrast visual acuity, functional visual acuity, keratoconjunctival epithelial damage, and fluorescein tear film break-up time were examined, and 18 subjective symptoms of eye fatigue were evaluated by questionnaire. Adverse events were reported via medical interviews. Data were collected both before and after VDT load at baseline, and 4, and 8 weeks after daily supplementation with either BE or placebo. RESULTS: Of 281 participants screened, 88 having relatively lower levels of CFF and NPA were enrolled in the study. Of these, 37 control and 43 BE group subjects completed the study. The VDT load-induced reduction in CFF was alleviated after 8 weeks of BE supplementation (95% confidence interval, 0.10-1.60; p=0.023), in contrast to placebo supplementation, while NPA variation was not. Of the subjective symptoms of eye fatigue, VDT load-induced ocular fatigue sensation, ocular pain, eye heaviness, uncomfortable sensation, and foreign body sensation were mitigated more in the BE group than in the control group, at week 8 (p<0.05). There were no severe adverse events in either group. CONCLUSIONS: BE supplementation improved some of the objective and subjective parameters of eye fatigue induced by VDT loads.


Assuntos
Astenopia/dietoterapia , Astenopia/prevenção & controle , Terminais de Computador , Suplementos Nutricionais , Extratos Vegetais/farmacologia , Vaccinium myrtillus/química , Acuidade Visual/efeitos dos fármacos , Acuidade Visual/fisiologia , Adulto , Astenopia/patologia , Astenopia/fisiopatologia , Túnica Conjuntiva/efeitos dos fármacos , Túnica Conjuntiva/patologia , Suplementos Nutricionais/efeitos adversos , Método Duplo-Cego , Feminino , Humanos , Japão , Masculino , Extratos Vegetais/efeitos adversos , Inquéritos e Questionários , Lágrimas , Adulto Jovem
2.
J Nutr Health Aging ; 16(5): 478-81, 2012 May.
Artigo em Inglês | MEDLINE | ID: mdl-22555795

RESUMO

OBJECTIVE: To determine the antioxidant supplementation effect on accommodation among VDT users. DESIGN: A double blind randomized placebo controlled study. Registered under ClinicalTrials.gov Identifier No. NCT00877201. PARTICIPANTS AND CONTROLS: Fourty right eyes of 40 healthy VDT users (30 females, 10 males, mean age: 43.8±2.8 years, range: 40-49 years). 20 subjects (15 females, 5 males; mean age: 44.0±2.7 years, range: 40-49 years). METHODS: Subjects were required to take an antioxidant supplement, 20 age and sex matched subjects (15 females, 5 males; mean age: 43.6±3.1 years, range: 40-49 years) were required to take placebo medication for 4 weeks. RESULTS: The mean of the change in accommodation power was significantly higher in the group receiving antioxidant supplements (0.20±0.50 Diopter(D)) compared to the placebo group (-0.12±0.48(D)) (p<0.05). CONCLUSIONS: Antioxidant supplementation was observed to improve accommodation in Japanese Visual Display Terminal (VDT) Users.


Assuntos
Acomodação Ocular/efeitos dos fármacos , Antioxidantes/uso terapêutico , Terminais de Computador , Suplementos Nutricionais , Adulto , Método Duplo-Cego , Feminino , Humanos , Japão , Masculino , Pessoa de Meia-Idade
3.
Diabetologia ; 53(5): 971-9, 2010 May.
Artigo em Inglês | MEDLINE | ID: mdl-20162412

RESUMO

AIMS/HYPOTHESIS: Diabetic retinopathy is a progressive neurodegenerative disease, but the underlying mechanism is still obscure. Here, we focused on oxidative stress in the retina, and analysed its influence on retinal neurodegeneration, using an antioxidant, lutein. METHODS: C57BL/6 mice with streptozotocin-induced diabetes were constantly fed either a lutein-supplemented diet or a control diet from the onset of diabetes, and their metabolic data were recorded. In 1-month-diabetic mice, reactive oxygen species (ROS) in the retina were measured using dihydroethidium and visual function was evaluated by electroretinograms. Levels of activated extracellular signal-regulated kinase (ERK), synaptophysin and brain-derived neurotrophic factor (BDNF) were also measured by immunoblotting in the retina of 1-month-diabetic mice. In the retinal sections of 4-month-diabetic mice, histological changes, cleaved caspase-3 and TUNEL staining were analysed. RESULTS: Lutein did not affect the metabolic status of the diabetic mice, but it prevented ROS generation in the retina and the visual impairment induced by diabetes. ERK activation, the subsequent synaptophysin reduction, and the BDNF depletion in the diabetic retina were all prevented by lutein. Later, in 4-month-diabetic mice, a decrease in the thickness of the inner plexiform and nuclear layers, and ganglion cell number, together with increase in cleaved caspase-3- and TUNEL-positive cells, were avoided in the retina of lutein-fed mice. CONCLUSIONS/INTERPRETATION: The results indicated that local oxidative stress that has a neurodegenerative influence in the diabetic retina is prevented by constant intake of a lutein-supplemented diet. The antioxidant, lutein may be a potential therapeutic approach to protect visual function in diabetes.


Assuntos
Diabetes Mellitus Experimental/metabolismo , Retinopatia Diabética/metabolismo , Suplementos Nutricionais , Luteína/administração & dosagem , Degeneração Neural/metabolismo , Retina/metabolismo , Análise de Variância , Animais , Western Blotting , Fator Neurotrófico Derivado do Encéfalo/metabolismo , Diabetes Mellitus Experimental/patologia , Retinopatia Diabética/patologia , Retinopatia Diabética/prevenção & controle , MAP Quinases Reguladas por Sinal Extracelular/metabolismo , Luteína/metabolismo , Camundongos , Degeneração Neural/patologia , Estresse Oxidativo/efeitos dos fármacos , Espécies Reativas de Oxigênio/metabolismo , Retina/efeitos dos fármacos , Retina/patologia , Sinaptofisina/metabolismo
4.
Clin Exp Immunol ; 149(3): 586-95, 2007 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-17614971

RESUMO

Regulation of the adhesion of mononuclear cells to endothelial cells is considered to be a critical step for the treatment of inflammatory diseases, including autoimmune diseases. K-13182 was identified as a novel inhibitor for these adhesions. K-13182 inhibited the expression of vascular cell adhesion molecule-1 (VCAM-1, CD106) on human umbilical vein endothelial cells (HUVECs) and on mouse vascular endothelial cell line (MAECs) induced by tumour necrosis factor (TNF)-alpha. K-13182 also inhibited the adhesion of mononuclear cells to these HUVECs and MAECs, indicating that K-13182 suppressed these adhesions mediated by cellular adhesion molecules including VCAM-1. To evaluate the therapeutic effect in autoimmune disease model mice, K-13182 was orally administered to non-obese diabetic (NOD) mice as Sjögren's syndrome (SS) model mice. Severe destructive inflammatory lesions were observed in the lacrimal glands of vehicle-treated control mice; however, 8-week administration of K-13182 inhibited the mononuclear cell infiltration into the inflammatory lesions of the lacrimal glands. In K-13182-treated mice, the decrease in tear secretion was also prevented compared to the control mice. In addition, the apoptosis and the expression of FasL (CD178), perforin, and granzyme A was suppressed in the lacrimal glands of K-13182-treated mice. Therefore, K-13182 demonstrated the possibility of therapeutic efficacy for the inflammatory region of autoimmune disease model mice. These data reveal that VCAM-1 is a promising target molecule for the treatment of autoimmune diseases as a therapeutic strategy and that K-13182 has the potential as a new anti-inflammatory drug for SS.


Assuntos
Anti-Inflamatórios/uso terapêutico , Dacriocistite/tratamento farmacológico , Síndrome de Sjogren/tratamento farmacológico , Administração Oral , Animais , Anti-Inflamatórios/farmacologia , Adesão Celular/efeitos dos fármacos , Células Cultivadas , Dacriocistite/metabolismo , Dacriocistite/patologia , Modelos Animais de Doenças , Relação Dose-Resposta a Droga , Avaliação Pré-Clínica de Medicamentos , Endotélio Vascular/efeitos dos fármacos , Endotélio Vascular/metabolismo , Regulação da Expressão Gênica/efeitos dos fármacos , Masculino , Camundongos , Camundongos Endogâmicos NOD , Reação em Cadeia da Polimerase Via Transcriptase Reversa/métodos , Síndrome de Sjogren/metabolismo , Síndrome de Sjogren/patologia , Molécula 1 de Adesão de Célula Vascular/genética , Molécula 1 de Adesão de Célula Vascular/metabolismo
5.
Br J Ophthalmol ; 86(12): 1403-7, 2002 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-12446375

RESUMO

AIM: To test the short term efficacy and safety of an infrared warm compression device (IWCD, Eye Hot, Cept Co, Tokyo, Japan) as treatment for non-inflamed meibomian gland dysfunction (MGD). METHODS: 37 subjects with non-inflamed obstructive MGD, with and without aqueous tear deficiency (ATD) dry eye, participated in a prospective non-comparative interventional case series. Symptom scores, face scores, tear evaporation rates, fluorescein and rose bengal vital staining, tear break up time (BUT), Schirmer test, meibomian gland obstruction, and meibography were compared before and after 2 weeks of therapy. RESULTS: In a total of 37 cases, total subjective symptom scores and subjective face scores improved significantly, from 12.3 (SD 5.9) to 8.4 (6.1), and from 7.0 (1.7) to 5.3 (2.0) (both p <0.0001). The results for tear evaporation rates during forced blinking (p = 0.002), fluorescein staining (p = 0.03), rose bengal staining (p = 0.03), BUT (p <0.0001), and meibomian gland orifice obstruction score (p <0.0001) had also improved significantly at the end of the 2 week period of infrared thermotherapy. No complaints and/or complications of the IWCD were reported. CONCLUSION: The IWCD was effective and safe for the treatment of MGD. Improved tear stability associated with release of meibum is a possible mechanism of this treatment.


Assuntos
Síndromes do Olho Seco/terapia , Doenças Palpebrais/terapia , Raios Infravermelhos/uso terapêutico , Glândulas Tarsais , Adulto , Idoso , Síndromes do Olho Seco/etiologia , Feminino , Temperatura Alta/uso terapêutico , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Lágrimas/metabolismo
7.
Cornea ; 20(8): 807-10, 2001 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-11685056

RESUMO

PURPOSE: To determine the efficacy of autologous serum drops in the treatment of superior limbic keratoconjunctivitis (SLK). METHODS: Twenty-two eyes of 11 patients were diagnosed with SLK. All eyes were treated with 20% diluted autologous serum eyedrops 10 times a day in addition to ongoing treatment of dry eye. Fluorescein and rose bengal staining scores, as well as subjective symptom gradings, were performed before and after 4 weeks of therapy. RESULTS: Nine of the 11 patients responded well to treatment (82%). The average rose bengal and fluorescein score improved ( p < 0.05), and there was subjective improvement. CONCLUSION: Autologous serum application can be used as an alternative mode of therapy in SLK.


Assuntos
Sangue , Ceratoconjuntivite/terapia , Administração Tópica , Adulto , Idoso , Feminino , Fluoresceína , Fluorofotometria , Humanos , Limbo da Córnea , Pessoa de Meia-Idade , Rosa Bengala , Lágrimas/metabolismo
9.
Cornea ; 18(2): 188-93, 1999 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-10090365

RESUMO

PURPOSE: To evaluate our newly developed infrared heater (IRH) and compare it to a broad-spectrum heater (BSH) for warming the eyelids. MATERIALS AND METHODS: Ten normal subjects were enrolled in this study. All measurements were recorded in a room with temperature 23 degrees C, 40% humidity, and no wind. The IRH is composed of two hard eye patches that have light-emitting diodes (LEDs) emitting near-infrared radiation. We first compared the temperature rises in the cornea, lacrimal gland, and eyelids after warming through closed eyelids with the IRH for 5 and 10 min. Next, we compared warming with the IRH or BSH for 30 min. We then used the IRH for 5 min with the eyes open to confirm its safety. Finally, we determined subjective feeling after warming the eyes. RESULTS: Direct comparison of 5 versus 10 min of warming with the IRH showed no significant differences in temperature rises in the upper eyelid (p = 0.09). The IRH caused significantly more heating (p < 0.05) than did the BSH everywhere except the cornea. The temperatures never rose above 37.7 degrees C for either heater during 30 min or with the IRH with the eyes open for 5 min. The subjects' comfort level rose significantly (p < 0.05) after treatment with the IRH. CONCLUSIONS: Our study showed the efficacy and safety of warming the eyelids with a newly developed IRH. Only 5 min is necessary to increase ocular temperature and enhance comfort.


Assuntos
Pálpebras , Hipertermia Induzida/instrumentação , Oftalmologia/instrumentação , Adulto , Temperatura Corporal , Segurança de Equipamentos , Oftalmopatias/terapia , Feminino , Temperatura Alta , Humanos , Raios Infravermelhos , Masculino , Termografia
10.
Am J Ophthalmol ; 124(1): 80-7, 1997 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-9222236

RESUMO

PURPOSE: To test the hypothesis that superior limbic keratoconjunctivitis is caused by insufficient tear supply to the superior keratoconjunctiva. METHODS: We used cautery and sutures to permanently occlude the lacrimal puncta of 11 patients (22 eyes) with superior limbic keratoconjunctivitis for whom topical treatment was ineffective. RESULTS: All 11 patients (22 eyes) responded favorably to lacrimal punctal occlusion. After lacrimal punctal occlusion, rose bengal and fluorescein staining (both on a scale of 0 [no staining] to 9 [complete staining]) were reduced (mean +/- SD, 2.7 +/- 1.6 to 1.1 +/- 1.8 and 1.4 +/- 1.2 to 0.4 +/- 0.8, respectively). Impression cytology disclosed improvement of squamous metaplasia in the superior conjunctiva as well as increased goblet cells in nine of 13 eyes (69%) examined. Subjective symptoms improved in all 22 eyes (100%). CONCLUSIONS: Improvement of local tear deficiency to the superior limbic portion by punctal occlusion was an effective treatment in this small series. Superior limbic keratoconjunctivitis might be caused by the insufficient local tear supply.


Assuntos
Ceratoconjuntivite/cirurgia , Aparelho Lacrimal/cirurgia , Obstrução dos Ductos Lacrimais/etiologia , Adulto , Idoso , Cauterização/métodos , Feminino , Fluoresceína , Fluoresceínas , Corantes Fluorescentes , Seguimentos , Humanos , Ceratoconjuntivite/etiologia , Ceratoconjuntivite/metabolismo , Aparelho Lacrimal/metabolismo , Obstrução dos Ductos Lacrimais/metabolismo , Masculino , Pessoa de Meia-Idade , Rosa Bengala , Técnicas de Sutura , Lágrimas/metabolismo
12.
Graefes Arch Clin Exp Ophthalmol ; 235(11): 691-5, 1997 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-9407226

RESUMO

BACKGROUND: Since a potential exists for untoward effects on the cornea from the high magnetic fields and radio-frequency energies, and the further manipulation required for phosphorus-31 magnetic resonance spectroscopy (31P-MRS), we determined the effects of this technology on tissues using paired human corneas (n = 4) meeting criteria acceptable for transplantation. METHODS: Slit-lamp biomicroscopy, pachometry, specular microscopy, and redux fluorophotometry were performed on all corneas. One cornea of each pair was examined (< 30 min) by 31P-MRS. Following 31P-MRS, slit-lamp biomicroscopy, pachometry, and redox fluorophotometry were again performed. RESULTS: Data tabulated included the 31P energy modulus (1.37 +/- 0.28), the ATP/Pi (2.92 +/- 0.59) and SP/Pi (0.76 +/- 0.04) ratios, and the intracorneal pH (7.24 +/- 0.09). CONCLUSION: Since there were no significant differences in slit-lamp biomicroscopy, endothelial density and morphometry, cell counts, and pachometric and redox fluorophotometric measurements between corneas of each pair before and after 31P-MRS analysis, it was concluded that there was no detectable metabolic damage secondary to such analysis. This study suggests that MRS analysis of human eye-bank tissues does not damage the cornea metabolically and may provide a practical evaluation of the health of the cornea at the biochemical level.


Assuntos
Trifosfato de Adenosina/metabolismo , Córnea/fisiologia , Bancos de Olhos , Fósforo/metabolismo , Adulto , Idoso , Contagem de Células , Córnea/citologia , Endotélio Corneano/citologia , Fluorofotometria , Humanos , Concentração de Íons de Hidrogênio , Espectroscopia de Ressonância Magnética , Pessoa de Meia-Idade , Oxirredução , Isótopos de Fósforo
13.
Cornea ; 15(2): 120-8, 1996 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-8925658

RESUMO

Our purpose was to evaluate the efficacy of a new formulation of methylcellulose, preservative-free 0.5% hydroxypropyl methylcellulose (HPMC), for the treatment of dry eye. In the clinical part of our study, two groups of dry-eye patients, those with Sjögren's syndrome (SS) and those without (non-SS), were treated topically with 0.5% HPMC and evaluated for symptoms, ocular surface vital staining, tear breakup time (BUT), and tear evaporation rate from the ocular surface at 40% ambient humidity (TEROS40). In the in vivo part of the study, rose bengal uptake was measured in human conjunctival epithelial cells, which were cultured and incubated with or without 0.5% HPMC. Although symptoms improved in both groups, rose bengal and fluorescein staining and BUT improved significantly only in the SS group. TEROS40 increased for 30 min after instillation of 0.5% HPMC, but not after use of 0.1% sodium hyaluronate or saline-based artificial tears. Rose bengal uptake by cultured conjunctival epithelial cells was blocked by 0.5% HPMC. These findings suggest that 0.5% HPMC provides long coverage of and protection for the ocular surface. Patients with severe dry eye, such as in SS, are good candidates for this treatment.


Assuntos
Síndromes do Olho Seco/tratamento farmacológico , Metilcelulose/análogos & derivados , Adulto , Idoso , Túnica Conjuntiva/metabolismo , Síndromes do Olho Seco/complicações , Síndromes do Olho Seco/fisiopatologia , Feminino , Humanos , Derivados da Hipromelose , Masculino , Metilcelulose/uso terapêutico , Pessoa de Meia-Idade , Rosa Bengala/farmacocinética , Síndrome de Sjogren/complicações , Coloração e Rotulagem , Lágrimas/fisiologia
14.
Curr Eye Res ; 15(2): 209-13, 1996 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-8670730

RESUMO

Interleukin 4 (IL-4) may play a role in the development of allergic disease. We questioned whether IL-4 related phenomenon occurred on the surface of the conjunctiva during allergic conjunctivitis. Ten patients with cedar pollen-allergic conjunctivitis and 10 patients with postsurgical conjunctivitis were enrolled in this study. Cells were collected by brush cytology from the upper palpebral conjunctiva. After the cells were cultured for 24 hours, the levels of IL-4, IgE, and histamine were measured in the supernatants. An ELISA was used for histamine and a highly sensitive sandwich ELISA for IL-4 and IgE. Conjunctival cells were also stained and fixed by May-Grunwalds stain solution. The number of superficial cells, especially lymphocytes, were compared in the two groups. The total number of cells collected by brush cytology did not differ in allergic vs., postsurgical conjunctivitis. Lymphocytes were similarly present in such specimens. The levels of IL-4 (p = 0.01) and histamine (p = 0.02) significantly increased in the specimens from patients with allergic conjunctivitis, although IgE was not detected in both groups. There was a correlation between the level of IL-4 and histamine (p = 0.0001). Conjunctival cells in allergic conjunctivitis produced a larger amount of IL-4 and histamine for cedar pollen compared to the postsurgical conjunctivitis. As with other allergic diseases, IL-4 may play a role similar to that of histamine in the development of allergic conjunctivitis.


Assuntos
Túnica Conjuntiva/metabolismo , Conjuntivite Alérgica/metabolismo , Histamina/metabolismo , Interleucina-4/metabolismo , Adolescente , Adulto , Idoso , Alérgenos/imunologia , Criança , Túnica Conjuntiva/patologia , Conjuntivite/etiologia , Conjuntivite/metabolismo , Conjuntivite/patologia , Conjuntivite Alérgica/imunologia , Conjuntivite Alérgica/patologia , Ensaio de Imunoadsorção Enzimática , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pólen/imunologia , Complicações Pós-Operatórias
15.
Asian Pac J Allergy Immunol ; 13(2): 113-7, 1995 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-8703238

RESUMO

Allergic conjunctivitis caused by sugi pollen is considered to be strictly a "spring disease". However, a recent report indicated that sugi pollen is scattered not only in spring but in all seasons, especially in the autumn. We retrospectively determined the number of patients with allergic conjunctivitis caused by sugi pollen during each month for 3 consecutive years, and also investigated the growth of sugi male cones in November for four years. Diagnosis of allergic conjunctivitis was based on symptomatic complaints, clinical findings, and serum sugi pollen specific IgE measured by the Multiple Antigen Simultaneous Test 16. The annual incidence of allergic conjunctivitis peaked twice, once in spring and again in autumn. Scattering of sugi pollen occurred mostly in March and October, whilst the growth of sugi male cones was highest in November. Thus, allergy to sugi pollen can cause allergic conjunctivitis both in the spring and late autumn.


Assuntos
Alérgenos/efeitos adversos , Conjuntivite Alérgica/etiologia , Pólen , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Feminino , Humanos , Japão , Masculino , Pessoa de Meia-Idade , Estações do Ano
16.
Ophthalmology ; 102(2): 302-9, 1995 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-7862418

RESUMO

PURPOSE: The authors' clinical experience has suggested that there is a form of dry eye with only decreased tear break-up time, which is associated with allergic conjunctivitis. The current study was performed to verify this hypothesis. METHOD: The authors recruited patients with two types of dry eye syndrome, those with only decreased tear break-up (BUT type) and those with positive vital staining (staining type). Individuals without any symptoms or signs served as controls. All subjects were compared regarding symptoms, Schirmer and tear clearance test results, conjunctival papillary formation, antigen-specific serum-IgE level (s-IgE), and goblet cell density of the palpebral conjunctiva. Antigen-induced allergic conjunctivitis was produced in guinea pigs, and histopathologic changes of the conjunctiva were examined. RESULTS: Patients with the BUT-type dry eye syndrome were younger and their symptoms were as severe as the staining type. The Schirmer and tear clearance test results were better, and the papillary formation and s-IgE were observed more than in the BUT type. The average goblet cell density in the BUT-type syndrome was 625.4 +/- 193.2/mm2, which was significantly less than 1005.6 +/- 294.5/mm2 in the controls (P < 0.01). The average goblet cell density was significantly decreased in the allergic animals (10.40 +/- 1.11/0.2 mm) compared with that of the controls (16.21 +/- 0.26/0.2 mm) or the anti-allergic drug-treated group (13.69 +/- 0.30/0.2 mm) (P < 0.01). CONCLUSION: These results support the authors' hypothesis that decreased break-up time is in part associated with the decreased goblet cell density caused by allergic conjunctivitis.


Assuntos
Conjuntivite Alérgica/complicações , Síndromes do Olho Seco/etiologia , Lágrimas/metabolismo , Adulto , Alérgenos/imunologia , Animais , Contagem de Células , Túnica Conjuntiva/patologia , Conjuntivite Alérgica/imunologia , Conjuntivite Alérgica/patologia , Modelos Animais de Doenças , Síndromes do Olho Seco/metabolismo , Feminino , Cobaias , Humanos , Imunoglobulina E/análise , Masculino , Pessoa de Meia-Idade , Pólen/imunologia , Lágrimas/química
17.
Ophthalmologica ; 209(4): 208-11, 1995.
Artigo em Inglês | MEDLINE | ID: mdl-8545095

RESUMO

We assessed the safety and effectiveness of sub-Tenon's anesthesia, a local anesthesia, for strabismus surgery. For 15 surgeries, we used anesthesia by sub-Tenon's infusion, followed by direct infusion through a transconjunctival route with a local anesthetic agent. We found the procedure was simple, it minimized complications compared with other techniques and was effective in achieving rapid anesthesia. With the ocular movement remaining, we checked eye position by the alternative cover-uncover test at the end of surgery. We obtained good eye position for all patients. This method leads to good results for strabismus surgery.


Assuntos
Anestesia Local/métodos , Estrabismo/cirurgia , Adolescente , Adulto , Idoso , Anestésicos Locais/administração & dosagem , Túnica Conjuntiva , Movimentos Oculares , Fáscia , Feminino , Humanos , Injeções , Lidocaína/administração & dosagem , Masculino , Pessoa de Meia-Idade , Soluções Oftálmicas , Órbita
18.
Rheum Dis Clin North Am ; 18(3): 673-82, 1992 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-1496167

RESUMO

Today, as with western countries, diagnosis and treatment of Sjögren's syndrome (SS) patients in Japan are carried out by a team effort. The clinical manifestations of Japanese SS patients are quite similar also. There are, however, several minor modifications in the diagnosis and treatment of SS patients in Japan, which are presented in this article.


Assuntos
Síndrome de Sjogren/diagnóstico , Síndrome de Sjogren/terapia , Humanos , Japão , Fitoterapia , Estados Unidos
19.
Exp Eye Res ; 51(4): 345-9, 1990 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-2209747

RESUMO

Experimental diabetic and galactosemic animal models are widely used to study diabetes-induced complications. Galactose feeding can rapidly produce cataract, retinopathy and nephropathy; it is therefore favored over the diabetic model. Although the common feature for both models is the activation of aldose reductase, there are substantial differences between the two--not only does the rate of cataract progression differ but the metabolic patterns are far more complex than for polyol production alone. We here present the result of a comparison between diabetic and galactosemic lenses and show the differences in phosphorus and aldose metabolism, cell integrity and osmotic environment.


Assuntos
Catarata/metabolismo , Galactosemias/complicações , Cristalino/metabolismo , Animais , Catarata/etiologia , Galactitol/metabolismo , Galactose/metabolismo , Espectroscopia de Ressonância Magnética , Masculino , Concentração Osmolar , Fósforo/metabolismo , Ratos , Ratos Endogâmicos
20.
Exp Eye Res ; 49(5): 769-75, 1989 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-2591493

RESUMO

The biochemistry of contact lens-cornea interaction is not well understood, although previous studies have suggested that corneal metabolic changes may be the underlying factor in morphological alterations. Using a rabbit model, this interaction has been examined with 31P nuclear magnetic resonance (NMR) spectroscopy, which detects signals principally from the epithelium. The examination was supplemented with electron microscopy and histochemistry. Polymethylmethacrylate lenses caused reversible changes, including activation of anaerobic glycolysis and disturbance of membrane metabolite levels. These changes were far more severe than those occurring during prolonged eye closure. There appears to be an association between cellular deterioration and loss of membrane metabolites. On the other hand, oxygen-permeable silicone lenses allowed maintenance of nearly normal metabolic patterns. These results show multifaceted corneal response to hard contact lens wear.


Assuntos
Lentes de Contato/efeitos adversos , Córnea/metabolismo , Animais , Epitélio/metabolismo , Glicólise , Espectroscopia de Ressonância Magnética , Metilmetacrilatos , Coelhos
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