Assuntos
Lobo Frontal/metabolismo , Bulbo/metabolismo , Mitocôndrias/metabolismo , Fosfatidilcolinas/farmacologia , Fosfolipídeos/metabolismo , Choque Hemorrágico/metabolismo , Animais , Gatos , Metabolismo Energético , Lobo Frontal/ultraestrutura , Membranas Intracelulares/metabolismo , Lipossomos , Bulbo/ultraestrutura , Lipídeos de Membrana/metabolismo , Choque Hemorrágico/tratamento farmacológicoAssuntos
Anti-Inflamatórios não Esteroides/uso terapêutico , Antineoplásicos/uso terapêutico , Benzidamina/uso terapêutico , Neoplasias dos Genitais Femininos/tratamento farmacológico , Vulvovaginite/tratamento farmacológico , Antineoplásicos/farmacologia , Benzidamina/farmacologia , Quimioterapia Adjuvante , Esquema de Medicação , Feminino , Neoplasias dos Genitais Femininos/complicações , Neoplasias dos Genitais Femininos/radioterapia , Neoplasias dos Genitais Femininos/cirurgia , Humanos , Resultado do Tratamento , Vulvovaginite/etiologiaRESUMO
Changes in peroxidation of hepatic tissue lipids were studied in experiments on rabbits with Cannon's traumatic shock according to products reacting with thiobarbituric acid. The lipid composition of hepatocyte plasma membranes was studied by thin-layer chromatography. The levels of lipid peroxidation products and the ratio of phospholipid fractions changed depending on the stage of the process. Administration of superoxide dismutase in the initial periods of shock reduced the raised level of products reacting with thiobarbituric acid and maintained the ratio of phospholipid fractions in the hepatocyte plasma membrane at the initial level.
Assuntos
Peroxidação de Lipídeos/efeitos dos fármacos , Fígado/efeitos dos fármacos , Lipídeos de Membrana/metabolismo , Fosfolipídeos/metabolismo , Choque Traumático/tratamento farmacológico , Animais , Cromatografia em Camada Fina/métodos , Avaliação Pré-Clínica de Medicamentos , Fígado/metabolismo , Lipídeos de Membrana/análise , Fosfolipídeos/análise , Coelhos , Choque Traumático/etiologia , Choque Traumático/metabolismo , Superóxido Dismutase/uso terapêutico , Fatores de TempoRESUMO
The effect of anisodamine on lipoprotein metabolism in the liver and hepatocyte membrane phospholipids was studied on a model of hemorrhagic shock. Preliminary injection of anisodamine raised the content of very low-density lipoproteins in blood of the central vessels and intensified the breakdown of low-density lipoproteins in the liver. The main changes in the phospholipid composition of the hepatocyte plasma membranes in hemorrhagic shock are associated with phosphatidylcholine and phosphatidylinositol. Decrease of the phosphatidylcholine content and increase of the phosphatidylinositol level were encountered. Anisodamine reduces the level of phosphatidylinositol in the hepatocyte plasma membranes and brings it close to normal.
Assuntos
Lipoproteínas/efeitos dos fármacos , Fígado/efeitos dos fármacos , Lipídeos de Membrana/metabolismo , Fosfolipídeos/metabolismo , Choque Hemorrágico/tratamento farmacológico , Alcaloides de Solanáceas/farmacologia , Animais , Gatos , Avaliação Pré-Clínica de Medicamentos , Heparina/farmacologia , Lipoproteínas/metabolismo , Lipoproteínas LDL/sangue , Lipoproteínas VLDL/sangue , Fígado/metabolismo , Choque Hemorrágico/metabolismo , Alcaloides de Solanáceas/uso terapêuticoRESUMO
Changes of the lipoprotein (LP) level in blood in the abdominal aorta and the portal and hepatic veins were studied in experiments on rabbits with Cannon's traumatic shock. The LP level was determined by spectrophotometry. The blood LP level changed depending on the stage of the shock. Administration of superoxide dismutase (an enzyme whose biosubstrates are only products of a free-radical process) in the initial period of shock has a normalizing effect on the level of the main LP classes.