RESUMO
Ten new nervogenic acid derivatives (1-4, 6-11) and one known compound (5) have been isolated from Liparis nervosa. Their structures were determined using extensive spectroscopic analysis, including 1D and 2D NMR experiments. Compounds 3, 4, 9, 10, and 11 were evaluated for their cytotoxicity against A549, H460, Hela, MCF-7, Caco2, and HepG2 human cancer cell lines.
Assuntos
Antineoplásicos Fitogênicos/química , Antineoplásicos Fitogênicos/farmacologia , Orchidaceae/química , Células CACO-2/efeitos dos fármacos , Linhagem Celular Tumoral , Dissacarídeos/química , Ensaios de Seleção de Medicamentos Antitumorais , Células HeLa/efeitos dos fármacos , Hemiterpenos/química , Humanos , Concentração Inibidora 50 , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Parabenos/químicaRESUMO
From the aerial parts of Senecio dianthus, five eremophilane glucosides (1, 2, 4-6) and one new eremophilenolide (7) were isolated, together with sixteen known compounds (3, 8-22). Their structures and relative configurations were elucidated on the basis of extensive spectroscopic analysis, including HR-ESI-MS, X-ray, CD, 1D- and 2D-NMR experiments.
Assuntos
Glucosídeos/química , Naftalenos/química , Senécio/química , Linhagem Celular Tumoral , Glucosídeos/toxicidade , Humanos , Espectroscopia de Ressonância Magnética , Naftalenos/toxicidade , Sesquiterpenos Policíclicos , SesquiterpenosRESUMO
A novel steroidal alkaloid, suchengbeisine (1), along with two known steroidal alkaloids, N-oxide of verticinone (2) and zhebeininoside (3), were isolated from the bulbs of Fritillaria shuchengensis S. C. Chen et S. F. Yin. The structures of these compounds were elucidated by intensive spectroscopic methods, including NMR, IR, CD and MS.