RESUMO
OBJECTIVE: To reveal the cutoff point and influencing factors in the dynamic change in phenotypic group in patients with stable angina pectoris (SAP) after Xinxuekang capsule treatment. METHODS: Five hundred and seventy-six SAP patients were randomly assigned to receive Xinxuekang (XXK) capsules or Compound Danshen (CDS) tablets for 8 weeks. Global similarity degree analysis and nonlinear mixed effects modeling (NONMEM) were employed to reveal the cutoff points and influencing factors in dynamic changes in the SAP phenotypic group. The phenotypic group was defined as the six phenotypes in SAP, including angina, choking sensation in the chest, palpitations, dark purple lips, ecchymosis on the tongue, and fine-choppy pulse, which were quantitatively evaluated on Days 0, 14, 28, 42, and 56. RESULTS: Variation in the six individual phenotypes and distribution of the SAP phenotypic profile were similar between the two experimental groups, but cutoff points for changes in the SAP phenotypic group were 7.28 and 10.73 weeks in XXK and CDS groups, respectively. Degree of severity of SAP as well as study site significantly affected the tendency for change in the SAP Xueyu Zheng in both XXK and CDS treatment groups. Different Chinese patent drugs affected the tendency for change in phenotypic group in patients with SAP. XXK was superior to CDS in controlling a clinical phenotypic group. CONCLUSION: Based on global similarity degree analysis and NONMEM, the cutoff point and influencing factors in phenomic variation of SAP may be determined, to improve the development and modification of treatment regimens.
Assuntos
Angina Estável/diagnóstico , Angina Estável/tratamento farmacológico , Medicamentos de Ervas Chinesas/uso terapêutico , Medicina Tradicional Chinesa/métodos , Adulto , Idoso , Cápsulas , Interpretação Estatística de Dados , Método Duplo-Cego , Medicamentos de Ervas Chinesas/administração & dosagem , Humanos , Pessoa de Meia-Idade , Salvia miltiorrhiza , Resultado do TratamentoRESUMO
The skull of the master of M392 tomb 5000 years ago unearthed in Guangrao County, Shandong province from 1995 to 1996 had a round and smooth-edged bone defect at its left parietal part. By using the methods of morphological observation and medical imaging, a contrastive research was made between the characteristics of unearthed skull specimens and that of the healing edge of fenestrate bone of the skull after craniotomy and that caused by all sorts of diseases. It is thus proved that the skull defect of M392 tomb master was caused by craniotomy.