RESUMO
A near-infrared (NIR) organic photothermal agent (PTA) to inhibit three types of heat shock proteins (HSPs) was synthesized, which could be activated under hypoxic conditions for low-temperature photothermal therapy (PTT) of cancer.
Assuntos
Nanopartículas , Neoplasias , Humanos , Fototerapia , Proteínas de Choque Térmico , Terapia Fototérmica , Temperatura , Neoplasias/metabolismo , Hipóxia/terapia , Linhagem Celular TumoralRESUMO
A heat shock protein-inhibiting photothermal agent (PTA) with endoplasmic reticulum targeting was synthesized to reduce the thermal resistance and enhance the effect of mild-temperature photothermal therapy (PTT).
Assuntos
Nanopartículas , Terapia Fototérmica , Fototerapia , Temperatura , Proteínas de Choque Térmico , Linhagem Celular TumoralRESUMO
An active tumor-targeting organic photochemotherapy agent via the combination of a an organic photothermal material and a naproxen prodrug was developed to precisely kill cancer cells and suppress the inflammatory response induced by cell necrosis; in vitro, and in vivo experiments illustrated its low cytotoxicity and excellent tumor inhibitory effect.
Assuntos
Hipertermia Induzida , Nanopartículas , Neoplasias , Fotoquimioterapia , Pró-Fármacos , Linhagem Celular Tumoral , Humanos , Naproxeno/farmacologia , Naproxeno/uso terapêutico , Neoplasias/tratamento farmacológico , Pró-Fármacos/farmacologia , Pró-Fármacos/uso terapêuticoRESUMO
Taking advantage of activatable and imaging-guided properties, stimuli-activated molecular photothermal agents (MPTAs) have drawn great attention in photothermal therapy (PTT) over the past decades. In this review, the recent progress in the study of stimuli-activated MPTAs is summarized from different stimuli, including pH, bioactive small molecules, and enzymes. The features and challenges of stimuli-activated MPTAs are also discussed. This review aims to motivate readers to design and synthesise more efficient MPTAs.