RESUMO
In this study, we found that alumina (Al2O3) may improve the degradation of phenolic pollutants by KMnO4 oxidation. In KMnO4/Al2O3 system, the removal efficiency of 2,4-Dibromophenol (2,4-DBP) was increased by 26.5%, and the apparent activation energy was decreased from 44.5 kJ/mol to 30.9 kJ/mol. The mechanism of Al2O3-catalytic was elucidated by electrochemical processes, X-ray photoelectron spectroscopy (XPS) characterization and theoretical analysis that the oxidation potential of MnO4- was improved from 0.46 V to 0.49 V. The improvement was attributed to the formation of coordination bonds between the O atoms in MnO4- and the empty P orbitals of the Al atoms in Al2O3 crystal leading to the even-more electron deficient state of MnO4-. The excellent reusability of Al2O3, the good performance on degradation of 2,4-DBP in real water, the satisfactory degradation of fixed-bed reactor, and the enhanced removal of 6 other phenolic pollutants demonstrated that the KMnO4/Al2O3 system has satisfactory potential industrial application value. This study offers evidence for the improvement of highly-efficient MnO4- oxidation systems.
Assuntos
Óxido de Alumínio , Poluentes Químicos da Água , Óxido de Alumínio/química , Óxidos/química , Oxirredução , Compostos de Manganês/química , Fenóis , Catálise , Poluentes Químicos da Água/químicaRESUMO
Bifunctional supramolecular prodrug vesicles have been successfully constructed based on the complexation between a glutathione (GSH)-responsive prodrug guest molecule (DNS-CPT) and a water-soluble pillar[5]arene (WP5) for cancer diagnosis and therapy. Under the microenvironment of cancer cells with high GSH concentration, 7-ethyl-10-hydroxycamptothecin (SN-38) with strong yellow fluorescence can be efficiently released from the prodrug DNS-CPT for drug location and cancer therapy.
Assuntos
Antineoplásicos/uso terapêutico , Camptotecina/análogos & derivados , Camptotecina/uso terapêutico , Portadores de Fármacos/química , Compostos Macrocíclicos/química , Pró-Fármacos/uso terapêutico , Animais , Antineoplásicos/síntese química , Antineoplásicos/farmacologia , Antineoplásicos/toxicidade , Apoptose/efeitos dos fármacos , Camptotecina/farmacologia , Camptotecina/toxicidade , Linhagem Celular Tumoral , Portadores de Fármacos/síntese química , Liberação Controlada de Fármacos , Feminino , Glutationa/química , Humanos , Compostos Macrocíclicos/síntese química , Camundongos , Camundongos Endogâmicos BALB C , Células NIH 3T3 , Nanopartículas/química , Tamanho da Partícula , Pró-Fármacos/síntese química , Pró-Fármacos/farmacologia , Pró-Fármacos/toxicidade , Solubilidade , Água , Ensaios Antitumorais Modelo de XenoenxertoRESUMO
A bola-type supra-amphiphile assembled from a water-soluble pillar[5]arene host (WP5) and a rod-coil guest molecule (G) containing a photoactive 9,10-dialkoxyanthracene group was successfully constructed, which could further assemble into a monolayer supramolecular vesicle. Interestingly, the photodecomposition rate of G was remarkably promoted after its aggregation with WP5, accompanied by the disassembly of the formed supramolecular vesicle, especially with the coassembly of a photosensitizer eosin Y, which has potential applications in phototherapy.