RESUMO
Two new triterpenoid saponins, namely ginsenoside Re8 (1) and notoginsenoside ST-8 (2), were isolated from ginseng medicinal fungal substance. Their structures were elucidated by spectroscopic data and chemical analysis.
Assuntos
Fungos/química , Panax/microbiologia , Saponinas/química , Triterpenos/química , Configuração de Carboidratos , Espectrometria de Massas por Ionização por Electrospray , DamaranosRESUMO
Two new dammarane-type triterpenoid saponins, namely ginsenoside Rk6 (1) and ginsenoside-Rh22 (2), were isolated from notoginseng medicinal fungal substance. The structures of 1 and 2 were established as 3ß,6α,12ß,26-tetrahydroxydammar-20(21),24(25)(E)-diene-6-O-ß-D-glucopyranoside and 3ß,6α, 20(S)-trihydroxy-12(R),23(R)-expoxy-13(S),17(S)-dammar-24-ene-6-O-ß-D-glucopyranoside on the basis of spectroscopic analysis and chemical analysis, respectively.
Assuntos
Fungos/química , Ginsenosídeos/isolamento & purificação , Panax/microbiologia , Saponinas/isolamento & purificação , Triterpenos/isolamento & purificação , Ginsenosídeos/química , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Folhas de Planta/química , Raízes de Plantas/química , Rizoma/química , Saponinas/química , Estereoisomerismo , Triterpenos/química , DamaranosRESUMO
Two new dammarane-type triterpenoid saponins, namely ginsenosides Rb4 (1) and Rb5 (2), were isolated from ginseng medicinal fungal substance. The structures of 1 and 2 were established as 3ß,12ß,20(S)-trihydroxydammar-24(25)-ene-3-O-[α-d-glucopyranosyl-(1â4)-ß-d-glucopyranosyl-(1â2)-ß-d-glucopyranosyl]-20-O-ß-d-glucopyranoside and 3ß,12ß,20(S)-trihydroxydammar-24(25)-ene-3-O-[α-d-glucopyranosyl-(1â4)-α-d-glucopyranosyl-(1â4)-ß-d-glucopyranosyl-(1â2)-ß-d-glucopyranosyl]-20-O-ß-d-glucopyranoside on the basis of spectroscopic analysis and chemical analysis, respectively.
Assuntos
Ginsenosídeos/isolamento & purificação , Panax/química , Saponinas/isolamento & purificação , Triterpenos/isolamento & purificação , Ginsenosídeos/química , Estrutura Molecular , Raízes de Plantas/química , Rizoma/química , Saponinas/química , Estereoisomerismo , Triterpenos/química , DamaranosRESUMO
Traditional Chinese herb medicines (TCHMs) have been used in the treatment of a variety of diseases for thousands of years in Asian countries. The active components of TCHMs usually exert combined synergistic therapeutic effects on multiple targets, but with less potential therapeutic effect based on routine indices than Western drugs. These complex effects make the assessment of the efficacy of TCHMs and the clarification of their underlying mechanisms very challenging, and therefore hinder their wider application and acceptance. Metabolomics is a crucial part of systems biology. It allows the quantitative measurement of large numbers of the low-molecular endogenous metabolites involved in metabolic pathways, and thus reflects the fundamental metabolism status of the body. Recently, dozens of metabolomic studies have been devoted to prove the efficacy/safety, explore the underlying mechanisms, and identify the potential biomarkers to access the action targets of TCHMs, with fruitful results. This article presents an overview of these studies, focusing on the progress made in exploring the pharmacology and toxicology of various herbal medicines.