[Cost-benefit analysis on the intervention of application iron-fortified soy sauce for anemia in Deqing 15-54 years women, Zhejiang].

OBJECTIVE: To make a cost-benefit analysis on anemia intervention with iron-fortified soy sauce in 15-54 years old women. METHODS: The study was conducted in Deqing county, Zhejiang province in 2012-2013. A total 585 women as sampling size were estimated with statistical model and randomly selected by probability proportionate to size sampling. Hemoglobin were measured before intervention and after 15 months. The cost of the intervention project were collected with manpower, communication and other invest. The benefit was estimated with profiling model. RESULTS: After the intervention, the anemia prevalence of sampled women decreased from 31.1% to 21.9%(P<0.01). The major cost of the project was 156 400 RMB, and total benefits result ing from projects were 1 448 485 RMB. The cost-benefit ratio of the project is 1∶9.49. If investing one yuan can produce economic benefits of nearly 9.49 yuan, therefore, the intervention projectis worth to be scaling up. Sensitivity analysis showed the result of this study was stable. CONCLUSION: The intervention can significantly reduce the prevalence of anemia in women, and reduce the economic burden of the diseases. .

Common variants in TGFBR2 and miR-518 genes are associated with hypertension in the Chinese population.

BACKGROUND: An animal study reported that TGF-ß1 maturation was linked to the homeostasis of blood pressure and elastogenesis of essential hypertension (EH). Recent advances require further research of TGF-ß1 receptor in EH. METHODS: A case-control study comprised of 2,012 adult hypertension case patients and 2,210 adult control subjects was conducted, and the association with blood pressure was further tested in children. Logistic regression and calculated genetic risk score were used to evaluate the effects of one single nucleotide polymorphism (SNP) and multiple SNPs on EH, respectively. RESULTS: The genetic risk score of 10 SNPs showed a significant association with hypertension; the odds ratio of the upper quartile vs. the lower quartile was 1.282 (P = 4.67 × 10(-3)). rs7256241 in miR-518 was significantly associated with diastolic blood pressure (DBP) change in control subjects (P = 0.002), and this association was also observed in children (P = 0.04). The systolic blood pressure (SBP) and DBP of female patients taking reserpine were higher with the C and G alleles of rs3773661 (P = 0.004) and rs7256241 (P = 0.002), respectively. In patients taking Zhen Ju Jiang Ya tablets, SBP and DBP decreased linearly with rs749794 (P = 0.004 and P = 0.048, respectively). SBP decreased linearly with rs1155705 (P = 0.007) and rs11709624 (P = 0.04), but increased with rs1036096 (P = 0.03) in male patients. In male patients taking Jiang Ya tablets, SBP increased linearly with rs11709624 (P = 0.007), DBP increased linearly with rs1155705 (P = 0.03) whereas decreased with rs7256241 (P = 0.04). CONCLUSIONS: Our results suggest that TGFBR2 and miR-518 harbor variants that increase the risk of EH and affect blood pressure homeostasis as well as efficacy of antihypertensive agents.

[Relationship between tea-drinking and anaemia of rural reproductive married women in a community-based cross-sectional study in China].

OBJECTIVE: To determine the prevalence of anaemia and the relationship between tea-drinking and anaemia in reproductive married women in rural China. METHOD: A cross-sectional study was carried out in four rural communities in Deqing County, Zhejiang Province, China. A total of 1425 reproductive married women at the ages of 20 to 49 years participated in this study and had a satisfactory measure of hemoglobin. Their general information, health status and lifestyle behaviors were collected. Hemoglobin was tested by Drabkin Method. Chi-square test, and binary and multinomial Logistic regression models were used for statistical analysis in SPSS 11.0. RESULT: Among 1425 subjects, the average concentration of hemoglobin were 114.7 +/- 17.0 g/L, the prevalences of anaemia were 63.3%, and most were mild and moderate anaemia (Such prevalence were 63.5%, 63.2% and 63.4% respectively at the ages of 20-30 years, 31-40 years, and 41-49 years.). Subjects with tea-drinking were higher in average concentration of hemoglobin than those of no tea-drinking (t = 3.33, P = 0.001). There were significant associations between tea-drinking and anaemia OR was 0.56 (95% CI: 0.45, 0.73). Further, such protective effects of tea-drinking were observed among subjects with different anaemia [ORs were 0.57 (95% CI: 0.43, 0.75), 0.57 (95% CI: 0.43, 0.75), and 0.28 (95% CI: 0.11, 0.70)] in mild, moderate and severe anaemia, respectively. CONCLUSION: The prevalence of anaemia in reproductive married women in rural of China could be higher and tea-drinking could be a possible protective factor.