RESUMO
Six new compounds, including two depsidones garciculendepsidones A and B (1 and 2), one prenylated xanthone garciculenxanthone (3) and three dimeric xanthones bigarciculenxanthones A-C (4-6), were isolated from the twigs and leaves of Garcinia esculenta Y. H. Li. Their structures were elucidated based on comprehensive analyses of spectral data, including HRESIMS, 1D and 2D NMR, and ECD calculation. All the isolates were tested for their cytotoxicity against five human cancer cell lines (myeloid leukemia HL-60, lung cancer A-549 cells, hepatocellular carcinoma SMMC-7721, breast cancer MDA-MB-231 and colon cancer SW480), among them, compounds 3-5 displayed cytotoxic potential, especially garciculenxanthone (3) had the lowest IC50 value of 8.2 µm for lung cancer A-549 cells.
Assuntos
Antineoplásicos Fitogênicos , Antineoplásicos , Depsídeos , Garcinia , Lactonas , Neoplasias Pulmonares , Xantonas , Humanos , Estrutura Molecular , Antineoplásicos Fitogênicos/farmacologia , Antineoplásicos Fitogênicos/química , Garcinia/química , Xantonas/farmacologia , Xantonas/química , Neoplasias Pulmonares/tratamento farmacológicoRESUMO
Two Daphniphyllum alkaloid and iridoid hybrids with the hitherto unknown decacyclic fused skeletons, hybridaphniphyllines A and B, along with one diamino Daphniphyllum alkaloid, daphnicyclidin I, were isolated from dried stems and leaves of Daphniphyllum longeracemosum. Their structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configuration of daphnicyclidin I was deduced by the CD exciton chirality method. A biogenetic pathway for 1 and 2 involving natural Diels-Alder cycloaddition is proposed.
Assuntos
Alcaloides/isolamento & purificação , Glicosídeos Iridoides/isolamento & purificação , Magnoliopsida/química , Extratos Vegetais/química , Alcaloides/química , Reação de Cicloadição , Glicosídeos Iridoides/química , Estrutura Molecular , Folhas de Planta/química , Caules de Planta/químicaRESUMO
Six eudesmane-type sesquiterpene lactones, named chlorantholides A-F, were isolated from the ethanol extract of Chloranthus elatior (Chloranthaceae) together with 12 known compounds. Their structures were elucidated on the basis of extensive spectroscopic analysis, and their absolute configurations were studied by the CD exciton chirality method. The structure of a recently reported eudesmanolide from Chloranthus anhuiensis: 8ß-hydroxy-1-oxoeudesma-3,7(11)-dien-12,8-olide, was also revised as 8ß-hydroxy-2-oxoeudesma-3,7(11)-dien-12,8-olide (chlorantholide D).
Assuntos
Gleiquênias/química , Lactonas/química , Sesquiterpenos/química , Lactonas/isolamento & purificação , Espectrometria de Massas , Ressonância Magnética Nuclear Biomolecular , Extratos Vegetais/química , Sesquiterpenos/isolamento & purificaçãoRESUMO
Two new xanthones, angustins A and B (1 and 2), were isolated from the aerial parts of Swertia angustifolia together with six known compounds (3-8). The structures of these two xanthones were elucidated by extensive analysis of the spectroscopic data. In addition, compounds 3 and 6-8 were isolated from this plant for the first time.