Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros

Base de dados
Ano de publicação
Tipo de documento
País de afiliação
Intervalo de ano de publicação
1.
BMC Res Notes ; 8: 269, 2015 Jun 26.
Artigo em Inglês | MEDLINE | ID: mdl-26111930

RESUMO

BACKGROUND: Every year thousands of people are victims of burns, mainly scald burns. Many of these victims have small size wounds and superficial partial thickness and do not seek specialized medical care. As in Brazil Casearia sylvestris Sw., popularly known as guaçatonga is widely used for its analgesic, antiseptic and anti-inflammatory activities, this study sought to evaluate the effects of its hydroalcoholic extract in healing process of burns injuries. METHODS: The obtained extract was validated applying a thin layer chromatography and sophisticated validation method using Bothrops jararacussu snake venom that is necrotic and inflammatory, and by which guaçatonga extract was able to neutralize the irreversible neuromuscular blockade induced by the venom. After induction of the scald injury, the animals were treated daily with saline solution spray; spray containing extract; biofilm; or biofilm impregnated with extract. RESULTS: Significant differences were observed between the four groups studied considering: extension of the healing area, neovascularization, fibroblast proliferation, and epithelialization. CONCLUSION: The anti-inflammatory and bactericidal effects of C. sylvestris Sw. suggests a potential therapeutic benefit in the treatment of inflammatory conditions in second-degree scald burn injuries, as well as, counteracting against the in vitro paralysis induced by B. jararacussu venom.


Assuntos
Analgésicos/farmacologia , Anti-Inflamatórios/farmacologia , Antivenenos/farmacologia , Queimaduras/tratamento farmacológico , Casearia/química , Fármacos Neuroprotetores/farmacologia , Cicatrização/efeitos dos fármacos , Analgésicos/isolamento & purificação , Animais , Anti-Inflamatórios/isolamento & purificação , Antivenenos/isolamento & purificação , Bothrops/metabolismo , Queimaduras/patologia , Venenos de Crotalídeos/antagonistas & inibidores , Venenos de Crotalídeos/isolamento & purificação , Venenos de Crotalídeos/toxicidade , Temperatura Alta , Masculino , Camundongos , Fármacos Neuroprotetores/isolamento & purificação , Extratos Vegetais/química , Ratos Wistar , Pele/efeitos dos fármacos , Pele/lesões , Pele/patologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA