The schizophrenia risk locus in SLC39A8 alters brain metal transport and plasma glycosylation.

A common missense variant in SLC39A8 is convincingly associated with schizophrenia and several additional phenotypes. Homozygous loss-of-function mutations in SLC39A8 result in undetectable serum manganese (Mn) and a Congenital Disorder of Glycosylation (CDG) due to the exquisite sensitivity of glycosyltransferases to Mn concentration. Here, we identified several Mn-related changes in human carriers of the common SLC39A8 missense allele. Analysis of structural brain MRI scans showed a dose-dependent change in the ratio of T2w to T1w signal in several regions. Comprehensive trace element analysis confirmed a specific reduction of only serum Mn, and plasma protein N-glycome profiling revealed reduced complexity and branching. N-glycome profiling from two individuals with SLC39A8-CDG showed similar but more severe alterations in branching that improved with Mn supplementation, suggesting that the common variant exists on a spectrum of hypofunction with potential for reversibility. Characterizing the functional impact of this variant will enhance our understanding of schizophrenia pathogenesis and identify novel therapeutic targets and biomarkers.

Self-Regulatory Imagery and Physical Activity in Middle-Aged and Older Adults: A Social-Cognitive Perspective.

Limited research has investigated exercise imagery use in middle-aged and older adults and its relationship with affective and behavioral correlates. The study examined the association between self-regulatory imagery and physical activity (PA) through key social cognitive variables. Middle-aged and older adults (N = 299; M age = 59.73 years, SD = 7.73, range = 50 to 80) completed self-report measures assessing self-regulatory imagery use, self-efficacy, outcome expectations, perceived barriers, self-regulatory behavior, enjoyment, and PA levels. Path analysis supported a model (χ² [14] = 21.76, p = .08, CFI = .99, TLI = .97, SRMR = .03, RMSEA = .04) whereby self-regulatory imagery positively predicted self-efficacy, outcome expectations, and self-regulatory behaviors. Furthermore, self-regulatory imagery indirectly predicted barriers, outcome expectations, self-regulation, enjoyment, and PA. This research highlights self-regulatory imagery as an effective strategy in modifying exercise-related cognitions and behaviors. Incorporating social cognitive constructs into the design of imagery interventions may increase PA engagement.

Do the physical and environment PETTLEP elements predict sport imagery ability?

The present study aimed to examine whether physical and environment elements of PETTLEP imagery relate to the ability to image five types of sport imagery (i.e. skill, strategy, goal, affect and mastery). Two hundred and ninety participants (152 males, 148 females; Mage = 20.24 years, SD = 4.36) from various sports completed the Sport Imagery Ability Questionnaire (SIAQ), and a set of items designed specifically for the study to assess how frequently participants incorporate physical (e.g. 'I make small movements or gestures during the imagery') and environment (e.g. 'I image in the real training/competition environment') elements of PETTLEP imagery. Structural equation modelling tested a hypothesised model in which imagery priming (i.e. the best fitting physical and environment elements) significantly and positively predicted imagery ability of the different imagery types (skill, ß = 0.38; strategy, ß = 0.23; goal, ß = 0.21; affect, ß = 0.25; mastery, ß = 0.22). The model was a good fit to the data: χ2 (174) = 263.87, p < .001, CFI = .96, TLI = .95, SRMR = .09, RMSEA = 0.05 (90% CI = 0.03-0.05). Findings displayed that priming imagery with physical and environment elements is associated with better skill, strategy, goal, affect and mastery imagery ability. The findings extend models of imagery use by indicating that how athletes images may influence their imagery ability.

Challenge and threat imagery manipulates heart rate and anxiety responses to stress.

This study investigated the influence of different types of mental imagery on heart rate and anxiety responses to a standard psychological stress task. Using a within-design, 25 females (Mage=23.24; SD=4.19) imaged three different scripts (challenge, threat, and neutral) to manipulate appraisal of a speech preparation task. Following each script, participants completed the task. Heart rate was recorded during a resting baseline prior to each imagery script and during each speech preparation task. Cognitive and somatic anxiety and self-confidence were assessed prior to the speech preparation trials, and immediately prior to each speech preparation following imagery. Following threat imagery, participants reported the speech preparation task to be significantly more stressful and threatening, and experienced lower levels of confidence and more negative interpretations of their anxiety symptoms compared with the challenge and neutral imagery conditions. Additionally, there was a significantly greater increase in heart rate following threat imagery compared with challenge and neutral imagery. Findings demonstrate that imagery can alter stress appraisal and the accompanying cardiovascular and psychological responses to standardized stress tasks. Imagery interventions, acknowledging the stressful nature of events, but emphasising feelings of efficacy and control are likely to lead to more adaptive coping.

Comparing self-report and mental chronometry measures of motor imagery ability.

The present study investigated the relationship between two of the most common measures of motor imagery ability, self-report ratings, and chronometric assessment. This was done for three types of imagery modalities: external visual imagery (EVI), internal visual imagery (IVI), and kinesthetic imagery (KI). Measures of imagery ability (i.e. self-report and mental chronometry) were also compared across skill levels. Participants (N = 198) completed the Movement Imagery Questionnaire-3 (MIQ-3) to generate self-report ratings. Chronometric assessment was obtained by recording the duration of each MIQ-3 movement imaged and physically performed and then calculating a discrepancy score. There were no significant correlations between self-report and mental chronometry for any of the three motor imagery types (p > .05). When assessing the different types of motor imagery ability using self-report ratings, elite athletes had significantly higher KI than IVI, which was in turn significantly higher than EVI (p < .05). When assessing motor imagery ability using mental chronometry, there were no significant differences in imagery type (p > .05). Findings suggest both measures address different components of MI quality and should be used together to obtain a more comprehensive assessment of motor imagery ability.

Layered stimulus response training improves motor imagery ability and movement execution.

This study aimed to test Lang's bioinformational theory by comparing the effects of layered stimulus and response training (LSRT) with imagery practice on improvements in imagery ability and performance of a motor skill (golf putting) in 24 novices (age, M = 20.13 years; SD = 1.65; 12 female) low in imagery ability. Participants were randomly assigned to a LSRT (introducing stimulus and response propositions to an image in a layered approach), motor imagery (MI) practice, or visual imagery (VI) practice group. Following baseline measures of MI ability and golf putting performance, the LSRT and MI practice groups imaged successfully performing the golf putting task 5 times each day for 4 days whereas the VI practice group imaged the ball rolling into the hole. Only the LSRT group experienced an improvement in kinesthetic MI ability, MI ability of more complex skills, and actual golf putting performance. Results support bioinformational theory by demonstrating that LSRT can facilitate visual and kinesthetic MI ability and reiterate the importance of imagery ability to ensure MI is an effective prime for movement execution.

Measuring athlete imagery ability: the sport imagery ability questionnaire.

This research aimed to develop and provide initial validation of the Sport Imagery Ability Questionnaire (SIAQ). The SIAQ assesses athletes' ease of imaging different types of imagery content. Following an extensive pilot study, 375 athletes completed a 20-item SIAQ in Study 1. Exploratory factor analysis revealed a 4-factor model assessing skill, strategy, goal, and affect imagery ability. Confirmatory factor analysis (CFA) established this 4-factor structure in Study 2 (N = 363 athletes). In Study 3 (N = 438 athletes), additional items were added to create a fifth mastery imagery subscale that was confirmed through CFA. Study 4 (N = 220 athletes) compared the SIAQ to the Movement Imagery Questionnaire-3. Significant bivariate correlations (p < .05) confirmed the SIAQ's concurrent validity but demonstrated differences in imagery ability of different content. Overall, the SIAQ demonstrates good factorial validity, internal and temporal reliability, invariance across gender, and an ability to distinguish among athletes of different competitive levels. Findings highlight the importance of separately assessing imagery ability of different content.

The use of imagery to manipulate challenge and threat appraisal States in athletes.

The present study investigated whether imagery could manipulate athletes' appraisal of stress-evoking situations (i.e., challenge or threat) and whether psychological and cardiovascular responses and interpretations varied according to cognitive appraisal of three imagery scripts: challenge, neutral, and threat. Twenty athletes (M(age) = 20.85; SD = 1.76; 10 female, 10 male) imaged each script while heart rate, stroke volume, and cardiac output were obtained using Doppler echocardiography. State anxiety and self-confidence were assessed following each script using the Immediate Anxiety Measures Scale. During the imagery, a significant increase in heart rate, stroke volume, and cardiac output occurred for the challenge and threat scripts (p < .05). Although there were no differences in physiological response intensities for both stress-evoking scripts, these responses, along with anxiety symptoms, were interpreted as facilitative during the challenge script and debilitative during the threat script. Results support using imagery to facilitate adaptive stress appraisal.