1.
Bioorg Med Chem Lett
; 14(9): 2079-82, 2004 May 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15080982
RESUMO
We report the discovery of a novel class of glucocorticoid receptor (GR) antagonists based on the chromene molecular scaffold. The compounds exhibit good functional potency and an improved receptor selectivity profile for GR over other steroid receptors when compared to the classical steroidal GR-antagonist, RU-486.