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Food Chem Toxicol ; 106(Pt A): 78-85, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28545868

RESUMO

Atractylenolide III (ATL-III) is an active compound of Atractylodes lancea, which has been widely used for the treatment of cancer. Cancer is closely connected with inflammation, and many anti-inflammatory agents are also used to treat cancer. We investigated the influence of ATL-III on thymic stromal lymphopoietin (TSLP)-induced inflammatory reactions. Pretreatment with ATL-III suppressed murine double minute 2 levels and promoted p53 levels in TSLP-treated human mast cell, HMC-1 cells. Mast cell proliferation increased by TSLP or IL-3 stimulation was significantly decreased by ATL-III pretreatment. Interleukin (IL)-13 and phosphorylated signal transducer and activator of transcription 3, 5, and 6 levels in TSLP-treated HMC-1 cells were also decreased by ATL-III pretreatment. In addition, ATL-III decreased the TSLP-induced production of proinflammatory cytokines (IL-6, IL-1ß, tumor necrosis factor-α, and IL-8). ATL-III decreased the levels of Bcl2 and procaspase-3 and increased caspase-3 activation and cleaved PARP levels. Furthermore, ATL-III decreased TSLP-induced mast cell proliferation and the production of inflammatory cytokine by LAD2 cells. Taken together, these findings suggest that ATL-III plays a useful role as an anti-inflammatory agent and should be viewed as a potential anti-cancer agent.


Assuntos
Atractylodes/química , Proliferação de Células/efeitos dos fármacos , Citocinas/farmacologia , Lactonas/farmacologia , Mastócitos/citologia , Extratos Vegetais/farmacologia , Sesquiterpenos/farmacologia , Anti-Inflamatórios/farmacologia , Caspase 3/genética , Caspase 3/metabolismo , Linhagem Celular , Humanos , Interleucina-13/genética , Interleucina-13/metabolismo , Mastócitos/efeitos dos fármacos , Mastócitos/metabolismo , Fosforilação , Proteínas Proto-Oncogênicas c-mdm2/genética , Proteínas Proto-Oncogênicas c-mdm2/metabolismo , Fator de Transcrição STAT6/genética , Fator de Transcrição STAT6/metabolismo , Linfopoietina do Estroma do Timo
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