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Post-stroke cognitive impairment （PSCI） refers to a series of syndromes from mild cognitive impairment to dementia caused by stroke. The mitogen-activated protein kinases （MAPK）signaling pathway is a key pathway for transmitting cellular signals in mammals ，and p 38 is a classic branch of it. p 38 MAPK signaling pathway is involved in various pathophysiological processes such as cell growth ，differentiation，apoptosis and inflammatory response in central nervous system diseases. At present ，great progress has been made in clinical and basic experimental studies on prevention and treatment of PSCI by traditional Chinese medicine （TCM），but there is a lack of relevant systematic summary. Therefore ，this article summarizes the role of p 38 MAPK signaling pathway in PSCI and the pharmacological research progress of TCM in prevention and treatment of PSCI through p 38 MAPK signaling pathway.
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Objective:To research the clinical effect of Yi-yuan moxibustion on the bladder dysfunction after incomplete spinal cord injury Method:Forty patients with urinary retention were randomized into treatment group and control group,20 cases in each group.The two groups were treated by rehabilitation training,and the treatment group received Yi-yuan moxibustion,once a day,5d a week,8 weeks in total.Bladder volume and residual urine were tested by B-scan ultrasonography.After 8 week treatment,the curative effect was assessed.Result:One week after all treatments,the results of B-scan ultrasonography showed that bladder volume and residual urine volume of both groups are were improved than before.The curative effect after 6 weeks treatment suggests that the effective rate in control group was 55％ and the treatment group was e 90％.The difference was statistically significant (P＜0.05).Conclusion:Yi-yuan moxibustion is a kind of good therapy to ameliorate urinary retention caused by spinal cord injury.
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@# Objective To explore the clinical efficacy of scalp acupuncture on allomnesia post stroke. Methods 60 stroke patients with allomnesia were randomly divided into observation group (n=30) and control group (n=30). The control group accepted routine rehabilitation training for 4 weeks, while the observation group accepted scalp acupuncture in addition. They were evaluated with Rivermead Behavioral Memory Test (RBMT-II) before and after treatment. Results RBMT-Ⅱ scores improved in both groups after treatment (P<0.05), and improved more in the observation group than in the control group (P<0.05). Conclusion Scalp acupuncture may improve the effects of rehabilitation on the memory dysfunction in patients with stroke.
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@#Objective To observe the effect of acupuncture combined with moxibustion on heart rate variability (HRV) in patients with post-stroke depression. Methods 120 patients were divided into control group (n=60) and treatment group (n=60). Both groups took fluoxetine and accepted acupuncture therapy, and the treatment group accepted moxibustion additionally. Hamilton Depression Rating Scale-17 (HAMD-17) and the change of HRV were compared before and after treatment. Results The score of HAMD was lower, and the reductive ratio was higher in the treatment group than in the control group (P<0.05). The standard deviation of the mean of qualified normal sinus interval (SDNN) and standard deviation of sequential five-minute R-R interval means (SDANN) increased in both groups after treatment (P< 0.05), and were higher in the treatment group than in the control group (P<0.05). The root mean square differences of successive R-R intervals (RMSSD) and percentage of differences between adjacent normal sinus intervals greater than 50 ms (PNN50) decreased in both groups after treatment (P<0.05), and were lower in the treatment group than in the control group (P<0.05). The low frequency (LF), high frequency (HF) and LF/HF were higher in both groups after treatment (P<0.05), and were higher in the treatment group than in the control group (P< 0.05). Conclusion Acupuncture combined with moxibustion therapy can better adjust the function of autonomic nerve and reduce depression in patients with post-stroke depression.
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@#Objective To observe the effect of needle warming moxibustion on cognitive dysfunction after stroke. Methods 76 stroke patients with cognitive dysfunction were randomly divided into treatment group (n=38) and control group (n=38). The treatment group received needle warming moxibustion and routine rehabilitation for 4 weeks, while the control group only received routine rehabilitation. They were assessed with Montreal Cognitive Assessment (MoCA) and activities of daily living (ADL) scale before and after treatment. Results The score of MoCA and ADL improved in both groups (P<0.05), and improved more in the treatment group than in the control group (P<0.05) after treatment. Conclusion Needle warming moxibustion could improve cognitive function in patients after stroke and activities of daily living.
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Objective To investigate the clinical efficacy of heat-sensitive point thunder-fire moxibustion in treating knee osteoarthritis (KOA). Methods One hundred and forty-eight KOA patients were randomly allocated to treatment and control groups, 74 cases each. The treatment group received heat-sensitive point thunder-fire moxibustion and the control group took diclofenac sodium enteric-coated tablets. The Visual Analogue Scale (VAS) score, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score and 50 yards fastest walking time were observed in the two groups before and after 30 days of treatment. The clinical therapeutic effects were compared between the two groups. Results There were statistically significant pre-/post-treatment differences in the VAS score and WOMAC subscores in the two groups (P<0.01). There was a statistically significant pre-/post-treatment difference in 50 yards fastest walking time in the treatment group (P<0.05). There were statistically significant post-treatment differences in the VAS score, the WOMAC score and the WOMAC pain and stiffness scores between the treatment and control groups (P<0.01). There were statistically significant differences in the VAS and WOMAC scores at three months after treatment between the treatment and control groups (P<0.01). The total efficacy rate was 95.9%at the end of treatment and 95.6%at three months after treatment in the treatment group, and 86.1%at the end of treatment and 86.8%at three months after treatment in the control group; there were statistically significant differences between the two groups (P<0.05). Conclusion Heat-sensitive point thunder-fire moxibustion is an effective way to treat knee osteoarthritis.
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Objective To observe the clinical effect of umbilical moxibustion on constipation after stroke. Methods 60 patients were ran-domly divided into observation group and control group, with 30 cases in each group. Both groups were treated with rehabilitation training once a day, and the observation group received umbilical moxibustion treatment in addition, 1 hour every day, once in 2 days for 2 weeks. Total integral of clinical symptoms was collected and compared. Results The integrals decreased in both groups after treatment (P<0.001), and it was lower in the observation group than in the control group (P<0.05). The clinical effect was better in the observation group than in the control group (P<0.01). Conclusion Umbilical moxibustion can further improve the symptom of post-stroke constipation.
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Objective To observe the effect of blood-letting puncture and cupping therapy on patients with sensory dysfunction after stroke. Methods 60 patients with sensory dysfunction after stroke were randomized into treatment group (n=30) and control group (n=30). Both groups were treated with conventional medical treatment and rehabilitation therapy. The treatment group received blood-letting punc-ture and cupping therapy in addition, twice a week for 4 weeks. They were evaluated with Fugl-Meyer Assessment and modified Barthel In-dex (MBI) before and after treatment. Results The score of Fugl-meyer Assessment and MBI increased after treatment (P<0.01), and the scores were higher in the treatment group than in the control group (P<0.01). Conclusion Blood-letting puncture and cupping therapy can improve the recovery of sensory dysfunction and activities of daily living of patients with sensory dysfunction after stroke.
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Objective To explore the clinical efficacy of scalp acupuncture on allomnesia post stroke. Methods 60 stroke patients with allomnesia were randomly divided into observation group (n=30) and control group (n=30). The control group accepted routine rehabilita-tion training for 4 weeks, while the observation group accepted scalp acupuncture in addition. They were evaluated with Rivermead Behav-ioral Memory Test (RBMT-II) before and after treatment. Results RBMT-Ⅱscores improved in both groups after treatment (P<0.05), and improved more in the observation group than in the control group (P<0.05). Conclusion Scalp acupuncture may improve the effects of reha-bilitation on the memory dysfunction in patients with stroke.
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Objective To observe the effect of needle warming moxibustion on cognitive dysfunction after stroke. Methods 76 stroke pa-tients with cognitive dysfunction were randomly divided into treatment group (n=38) and control group (n=38). The treatment group re-ceived needle warming moxibustion and routine rehabilitation for 4 weeks, while the control group only received routine rehabilitation. They were assessed with Montreal Cognitive Assessment (MoCA) and activities of daily living (ADL) scale before and after treatment. Re-sults The score of MoCA and ADL improved in both groups (P<0.05), and improved more in the treatment group than in the control group (P<0.05) after treatment. Conclusion Needle warming moxibustion could improve cognitive function in patients after stroke and activities of daily living.
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Objective To observe the effect of acupuncture combined with moxibustion on heart rate variability (HRV) in patients with post-stroke depression. Methods 120 patients were divided into control group (n=60) and treatment group (n=60). Both groups took fluox-etine and accepted acupuncture therapy, and the treatment group accepted moxibustion additionally. Hamilton Depression Rating Scale-17 (HAMD-17) and the change of HRV were compared before and after treatment. Results The score of HAMD was lower, and the reductive ratio was higher in the treatment group than in the control group (P<0.05). The standard deviation of the mean of qualified normal sinus in-terval (SDNN) and standard deviation of sequential five-minute R-R interval means (SDANN) increased in both groups after treatment (P<0.05), and were higher in the treatment group than in the control group (P<0.05). The root mean square differences of successive R-R inter-vals (RMSSD) and percentage of differences between adjacent normal sinus intervals greater than 50 ms (PNN50) decreased in both groups after treatment (P<0.05), and were lower in the treatment group than in the control group (P<0.05). The low frequency (LF), high frequency (HF) and LF/HF were higher in both groups after treatment (P<0.05), and were higher in the treatment group than in the control group (P<0.05). Conclusion Acupuncture combined with moxibustion therapy can better adjust the function of autonomic nerve and reduce depres-sion in patients with post-stroke depression.
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@#Objective To observe the effect of acupuncture combined with moxibustion on heart rate variability (HRV) in patients with post-stroke depression. Methods 120 patients were divided into control group (n=60) and treatment group (n=60). Both groups took fluoxetine and accepted acupuncture therapy, and the treatment group accepted moxibustion additionally. Hamilton Depression Rating Scale-17 (HAMD-17) and the change of HRV were compared before and after treatment. Results The score of HAMD was lower, and the reductive ratio was higher in the treatment group than in the control group (P<0.05). The standard deviation of the mean of qualified normal sinus interval (SDNN) and standard deviation of sequential five-minute R-R interval means (SDANN) increased in both groups after treatment (P< 0.05), and were higher in the treatment group than in the control group (P<0.05). The root mean square differences of successive R-R intervals (RMSSD) and percentage of differences between adjacent normal sinus intervals greater than 50 ms (PNN50) decreased in both groups after treatment (P<0.05), and were lower in the treatment group than in the control group (P<0.05). The low frequency (LF), high frequency (HF) and LF/HF were higher in both groups after treatment (P<0.05), and were higher in the treatment group than in the control group (P< 0.05). Conclusion Acupuncture combined with moxibustion therapy can better adjust the function of autonomic nerve and reduce depression in patients with post-stroke depression.
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@#Objective To observe the effect of needle warming moxibustion on cognitive dysfunction after stroke. Methods 76 stroke patients with cognitive dysfunction were randomly divided into treatment group (n=38) and control group (n=38). The treatment group received needle warming moxibustion and routine rehabilitation for 4 weeks, while the control group only received routine rehabilitation. They were assessed with Montreal Cognitive Assessment (MoCA) and activities of daily living (ADL) scale before and after treatment. Results The score of MoCA and ADL improved in both groups (P<0.05), and improved more in the treatment group than in the control group (P<0.05) after treatment. Conclusion Needle warming moxibustion could improve cognitive function in patients after stroke and activities of daily living.
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Objective To observe the effect of Du-moxibustion on cognitive impairment after stroke. Methods 60 patients with cogni-tive impairment after stroke were randomly divided into control group (n=30) and treatment group (n=30). They were treated with conven-tional medical treatment and rehabilitation training, the treatment group received Du-moxibustion treatment in addition with once a day, 6 days per week for 8 weeks. They were evaluated with modified Barthel Index (MBI) and Montreal Cognitive Assessment (MoCA) before and after treatment. Results The scores of MBI and MoCA increased after treatment (P<0.05) in both groups and the scores were higher in the treatment group than in the control group (P<0.05). Conclusion Du-moxibustion can further improve the cognitive function and activi-ties of daily living in stroke patients.
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<p><b>OBJECTIVE</b>To investigate the chemical constituents of Peperomia tetraphylla.</p><p><b>METHOD</b>The constituents of EtOAc-soluble portion were isolated and purified by chromatography. Their structures were identified by spectral features.</p><p><b>RESULT</b>Six amides were isolated and identified as, aristololactam All (1), aristololactam B II (2), N-trans-feruloyltyramine (3), N-trans-sinapoyltyramine (4), N-trans-feruloylmethoxytyramine (5), N-p-coumaroyltyramine (6).</p><p><b>CONCLUSION</b>All compounds were isolated from this plant for the first time.</p>