Effect of Breathing Meditation Training on Nursing Work Quality, Occurrence Risk of Adverse Events, and Attention Level of Operating Room Nurses.

Objective: To explore the effect of breathing meditation training on nursing work quality, occurrence risk of adverse events, and attention level of operating room nurses. Methods: Taking the starting time of breathing meditation training of operating room nurses in our hospital in July 2020 as the dividing line, operating room nurses who implemented routine management from April 2020 to June 2020 were selected as the control group (n=30), and operating room nurses who carried out breathing meditation training from July 2020 to September 2020 were included in the intervention group (n=30). The emotional state [Hamilton Anxiety Scale (HAMA) score, Hamilton Depression Scale (HAMD) score], Mindfulness Attention Awareness Scale (MAAS) score, electrocardiogram indicators (blood pressure, pulse, and respiration), electroencephalogram indicators (SMR wave, ß wave, and θ wave EEG frequency), attention level (attention quotient, visual attention, and auditory attention), nursing work quality (health education, theoretical knowledge, nursing operation, and operating room management) and the number of reported adverse events were compared between the two groups before and after training. Results: After breathing meditation training, the intervention group's Hamilton Anxiety Rating Scale (HAMA) and Hamilton Depression Rating Scale (HAMD) scores were significantly reduced (P < .05), while the Mindfulness Attention Awareness Scale (MAAS) score was significantly increased (P < .05). ). In addition, blood pressure and respiratory rate were reduced in the intervention group (P < .05), with significant differences compared with the control group (P < .05). The SMR waves and beta waves in the intervention group increased (P < .05), while theta waves decreased (P < .05). Attention quotient, visual attention and auditory attention scores were improved in the intervention group compared with the control group (P < .05). The scores of health education, theoretical knowledge, nursing operations and operating room management of the intervention group after training were higher than those of the control group (P < .05). The intervention group reported a lower number of adverse events than the control group (74.42% vs. 25.58%). The application of breathing meditation training in special training for operating room nurses can effectively relieve negative emotions, enhance mindfulness scores, reduce blood pressure and respiratory rate, regulate brain wave frequency, improve attention status and quality of nursing work, and reduce the risk of adverse events. These outcomes may have a positive impact on improving the quality of nursing practice and patient care in the operating room. For operating room nurses, the negative emotional stress caused by sustained high levels of mental concentration may affect work efficiency and the entire surgical process. Breathing meditation training can enhance nurses' emotional resilience, thereby improving the efficiency and safety of operating room care. Conclusion: The application of breathing meditation training in the special training of operating room nurses can effectively alleviate negative emotions, enhance the mindfulness score, reduce blood pressure and respiratory rate, regulate brain wave frequency, improve the attention state and nursing work quality, and reduce the occurrence risk of adverse events. Future research should conduct longitudinal studies to evaluate the long-term effects of breathing meditation training on the quality of nursing work and the prevention of adverse events. Additionally, research could explore advanced neuroimaging techniques to gain structural insights, integrate meditation into existing training programs, tailor interventions for different healthcare settings, assess patient outcomes, explore technology-assisted meditation, and investigate interprofessional collaboration. Through these pathways, a more complete understanding of the impact and best integration of breath meditation in healthcare settings can be achieved, providing valuable insights into improving the well-being of healthcare professionals and potentially overall patient care and satisfaction.

Kill two birds with one stone: Engineered exosome-mediated delivery of cholesterol modified YY1-siRNA enhances chemoradiotherapy sensitivity of glioblastoma.

Glioblastoma (GBM) is the most malignant tumor of the central nervous system in adults. Irradiation (IR) and temozolomide (TMZ) play an extremely important role in the treatment of GBM. However, major impediments to effective treatment are postoperative tumor recurrence and acquired resistance to chemoradiotherapy. Our previous studies confirm that Yin Yang 1 (YY1) is highly expressed in GBM, whereby it is associated with cell dedifferentiation, survival, and therapeutic resistance. Targeted delivery of small interfering RNA (siRNA) without blood-brain barrier (BBB) restriction for eradication of GBM represents a promising approach for therapeutic interventions. In this study, we utilize the engineering technology to generate T7 peptide-decorated exosome (T7-exo). T7 is a peptide specifically binding to the transferrin receptor. T7-exo shows excellent packaging and protection of cholesterol-modified Cy3-siYY1 while quickly releasing payloads in a cytoplasmic reductive environment. The engineered exosomes T7-siYY1-exo could deliver more effciently to GBM cells both in vitro and in vivo. Notably, in vitro experiments demonstrate that T7-siYY1-exo can enhance chemoradiotherapy sensitivity and reverse therapeutic resistance. Moreover, T7-siYY1-exo and TMZ/IR exert synergistic anti-GBM effect and significantly improves the survival time of GBM bearing mice. Our findings indicate that T7-siYY1-exo may be a potential approach to reverse the chemoradiotherapy resistance in GBM.

Valorization of fluid petroleum coke for efficient catalytic destruction of biomass gasification tar.

Large volumes of waste petroleum coke stockpiled in open yard not only represent a huge loss of valuable material but also pose a significant risk to the environment. This work proposed an innovative strategy for waste petroleum coke valorization by exploring its catalytic performance of biomass gasification tar destruction. Waste petroleum coke was firstly activated by potassium hydroxide (KOH) to obtain high specific surface area as well as low sulfur and ash contents. Petroleum coke derived catalyst showed superior performance than a commercial activated carbon derived catalyst for destruction of naphthalene as the tar model compound. The petroleum coke derived catalyst exhibited 99.1% naphthalene destruction efficiency at 800 °C but deactivated quickly under N2 atmosphere. Under H2 and steam atmospheres, the catalytic activities were 98.6% and 96.5% for 8 h, respectively. To study the correlation between catalytic performance and the structure of carbon catalyst, elemental analysis, scanning electron microscope (SEM) analysis, transmission electron microscope (TEM) analysis, X-ray powder diffraction (XRD) analysis, Brunauer-Emmett-Teller method (BET) analysis, Fourier transform infrared (FTIR) spectroscopy, temperature programmed oxidation (TPO) analysis and Raman spectroscopy were performed on both fresh and spent catalysts. Results demonstrated that the hydrogen-rich groups (small rings and amorphous carbon) and oxygen-containing groups may account for the good resistance to coke deposition under H2 and steam atmospheres.

Different rates of pollen and seed gene flow cause branch-length and geographic cytonuclear discordance within Asian butternuts.

Topological cytonuclear discordance is commonly observed in plant phylogenetic and phylogeographic studies, yet few studies have attempted to detect two other forms of cytonuclear discordance (branch length and geographical) and to uncover the causes of the discordance. We used the whole nuclear and chloroplast genome data from 80 individual Asian butternuts to reveal the pattern and processes of cytonuclear discordance. Our findings indicate that the chloroplast genome had substantially deeper divergence (branch-length discordance) and a steeper cline in the contact zone (geographic discordance) compared with the nuclear genome. After various hypothesis have been tested, the results suggest that incomplete lineage sorting, positive selection and cytonuclear incompatibility are probably insufficient to explain this pattern. However, isolation-by-distance analysis and gene flow estimation point to a much higher level of gene flow by pollen compared with by seeds, which may have slowed down lineage divergence and mediated wider contact for nuclear genome compared with the chloroplast genome. Altogether, this study highlights a critical role of sex-biased dispersal in causing discordance between the nuclear and plastid genome of Asian butternuts. Given its ubiquity among plants, asymmetric gene flow should be given a high priority in future studies of cytonuclear discordance.

Role of Arts Therapy in Patients with Breast and Gynecological Cancers: A Systematic Review and Meta-Analysis.

Background: Women with breast and gynecological cancers often experience adverse symptoms such as anxiety, depression, pain, and fatigue. Objective: The purpose of this meta-analysis was to clarify the role of arts therapy (based on music, painting, and dance) in quality of life and reported symptoms among women with breast and gynecological cancers. Methods: Articles on arts therapy were retrieved from relevant electronic databases through to May 2020. The outcomes (quality of life and symptoms such as anxiety, depression, pain, and fatigue) were estimated according to standard or validated scales that assessed psychological status and activities of daily living. The effect sizes for arts therapy were combined to show the standardized mean difference (SMD) and corresponding confidence interval (CI), and a random-effects model was used for computation. Results: In total, 19 randomized controlled studies were included in this meta-analysis. The pooled SMDs for arts therapy were statistically significant for quality of life (0.58; 95% CI: 0.02-1.13; p = 0.04), anxiety (-1.10; 95% CI: -1.88 to -0.32), depression (-0.71; 95% CI: -1.19 to -0.23), pain (-1.01; 95% CI; -1.97 to -0.08), and fatigue (-0.59; 95% CI: -1.18 to -0.00). However, the summary SMDs for arts therapy was not significant for sleep disturbance, anger, vigor, tension, confusion, and stress. Conclusion: This meta-analysis shows that arts therapy has favorable effects on improving quality of life and depression among patients with breast and gynecological cancers. Arts therapy also has positive effects on improving anxiety, pain, and fatigue symptoms among patients with breast cancer. Further studies are required to confirm the effect of arts therapy on anxiety, pain, and fatigue in patients with gynecological cancer.

The effects of art therapy on anxiety and depression in breast cancer patients: An updated meta-analysis.

OBJECTIVE: In this meta-analysis, we aimed to investigate the effects of art therapy on anxiety and depression in patients with breast cancer. METHODS: Electronic databases were searched for relevant studies through December 2019. Standardised mean differences (SMDs) were calculated as the effects of art therapy on improvement of anxiety and depression in women with breast cancer. The meta-analysis included nine studies involving a total of 446 participants. RESULTS: The summary SMD of art therapy for anxiety was -1.02 (95% confidence interval (CI), -2.08 to 0.04; p = .06). The pooled SMD of art therapy for depression was -0.73 (95% CI, -1.45 to -0.01; p = .046). In the age subgroup analysis, the summary SMD of art therapy for anxiety was -1.30 (95% CI, -2.45 to -0.14; p = .03) for a mean age of more than 55 years. The summary SMD of art therapy for depression was -1.01 (95% CI, -1.95 to -0.05; p = .04) for a mean age of less than 55 years. CONCLUSION: This meta-analysis revealed that art therapy demonstrates positive effects on depression but not anxiety in patients with breast cancer. There appears to be a critical age period for art therapy to alleviate anxiety or depression in these patients.

Comprehensive nursing based on feedforward control and postoperative FMA and SF-36 levels in femoral intertrochanteric fracture.

OBJECTIVE: To study the effect of comprehensive nursing based on the concept of feedforward control on postoperative FMA (Fugl-Meyer Assessment) and SF-36 (health status questionnaire) in patients with femoral trochanteric fracture. METHODS: 114 patients with femoral intertrochanteric fracture were enrolled in the study. Patients were divided into control group and observation group according to order of admission, 57 cases in each group. Both groups of patients received proximal femoral nail antirotation surgery, conventional nursing and feedforward control based comprehensive nursing. Nursing effects of the two groups of patients were compared. RESULTS: Anus first exhaust time, the time of getting out of bed and hospitalization time, and after nursing, SAS (Self-Rating Anxiety) and SDS (Self-Rating Depression) score of the observation group were significantly lower than those of the control group (p<0.05). FMA and SF-36 score of the observation group after surgical nursing were significantly higher than those of the control group (p<0.05). The total incidence of complications in the observation group was lower than that in the control group (p<0.05). CONCLUSIONS: Comprehensive care based on the concept of feedforward control has a better nursing effect for patients with intertrochanteric fracture, which can shorten the time of patient getting out of bed and hospitalization and reduce the incidence of post-complications.

Fabrication of multicolored patterns based on dye-doped cholesteric liquid crystals.

We developed a type of dye-doped cholesteric liquid crystal, which were used for fluorescence enhancement and dual-mode multicolor patterns. We added dye molecules (BBOT, coumarin 6 (C6) and rhodamine B (RhB)) to liquid crystals, and cholesteric liquid crystals (CLC) exhibited selective reflection characteristics. When the reflection wavelength overlaps with the peak of the fluorescent dye, the luminescence intensity of the dye molecules could be adjusted. We used two methods to adjust the reflection wavelength of the cholesteric liquid crystals by changing the content of chiral additives and the isomerization degree of azo molecules. We used the screen printing and stencil printing methods to combine liquid crystal particles containing different fluorescent colors to prepare multicolor patterns. Moreover, the photoisomerization characteristics of the azo molecules were also used to achieve brilliant firework-like images upon exposure to ultraviolet and visible light. In addition, we also realized a face-changing stunt with facial makeup during a performance in the Sichuan Opera, a traditional Chinese folk art. We made use of the difference between reflection color and luminescence intensity upon light irradiation to present orange, green, blue and dark-blue facial effects.

Maternal supplementation of nucleotides improves the behavioral development of prenatal ethanol-exposed mice.

Maternal ethanol consumption during pregnancy can induce learning deficits in the offspring. The objective of this study was to assess whether supplementation of exogenous nucleotides during pregnancy and lactation would ameliorate prenatal ethanol-induced learning and memory deficits in the offspring of mice, and to explore the possible mechanisms. In the present study, pregnant C57BL/6J mice were exposed to ethanol (5 g/kg body weight) intragastrically from gestational day (GD) 6 to GD15. The dams in exogenous nucleotide intervention groups were fed with feed containing 0.01%, 0.04%, or 0.16% nucleotide powder, with control and ethanol groups receiving normal feed. The dams were allowed to deliver naturally and to breast feed their offspring. After weaning, behavioral tests were carried out in the offspring of each group. Serum oxidation indexes were analyzed, and the hippocampus of each offspring was collected and detected for acetyl cholinesterase (AChE) activity and the expression of p-CREB, CREB, and BDNF. The results showed that maternal supplementation with exogenous nucleotides during pregnancy could ameliorate prenatal ethanol-induced learning and memory deficits in the offspring of mice, through improving their antioxidant capacity, reversing hippocampus AChE levels, and allowing the expression of some proteins related to learning and memory. However, different sensitivities were found between the two sexes.

Developmental effects of dietary nucleotides in second-generation weaned rats.

The aim of the present study was to evaluate dietary effects of dietary nucleotides (NTs) on developmental parameters in second-generation Sprague-Dawley rats. Experimental design was set up as six groups, including one control and five nucleotide administered groups, doses ranged from 0.01% to 1.28% nucleotides. First-generation (F0) rats were divided into two terms: (1) fed for 90-day study; (2) mated for offspring (F1). After weaning, each group of second-generation F1 rats was fed the control diet. Evaluating parameters were weight gain and food utilization ratios of rats, hematological and biochemical parameters, and organ pathology. The results showed that there was a greater weight gain and food utilization ratio in weaned rats (F0 and F1). Furthermore, weight gain and food utilization ratios were increased in the first 2 weeks of F1 male and the first week of F1 female rats. There were no significant changes in blood indicators of NT groups with the exception of decrease in aspartate aminotransferase and serum uric acid levels. Overall, it was demonstrated that NT supplements could promote the early growth and development at a 0.01% dose. Although NTs may have cumulative reproductive effects, they were safe even at a high-dose supplementation. Additionally, NT supplementation could promote restoration and optimize liver function.

Development and characterization of West Nile virus replicon expressing secreted Gaussia luciferase.

We developed a Gaussia luciferase (Gluc) reporter replicon of West Nile virus (WNV) and used it to quantify viral translation and RNA replication. The advantage of the Gluc replicon is that Gaussia luciferase is secreted into the culture medium from cells transfected with Gluc replicon RNA, and the medium can be assayed directly for luciferase activity. Using a known Flavivirus inhibitor (NITD008), we demonstrated that the Gluc-WNV replicon could be used for antiviral screening. The Gluc-WNV-Rep will be useful for research in antiviral drug development programs, as well as for studying viral replication and pathogenesis of WNV.