Regulatory effects of natural products on N6-methyladenosine modification: A novel therapeutic strategy for cancer.

N6-methyladenosine (m6A) is considered to be the most common and abundant epigenetics modification in messenger RNA (mRNA) and noncoding RNA. Abnormal modification of m6A is closely related to the occurrence, development, progression, and prognosis of cancer. m6A regulators have been identified as novel targets for anticancer drugs. Natural products, a rich source of traditional anticancer drugs, have been utilized for the development of m6A-targeting drugs. Here, we review the key role of m6A modification in cancer progression and explore the prospects and structural modification mechanisms of natural products as potential drugs targeting m6A modification for cancer treatment.

[Water environmental simulation of main contaminations in the Qiantang River at low water period].

Technical framework for water environment simulation of contaminations is established based on visualization and a spatial environmental model is built. The main two contaminations, namely NH: -N and TP, are simulated on the platform of MapInfo and Delft3D in the Qiantang River at the low water period, to analyze its space-time diversity. For NH4+ -N, the measured values are 0.19 mg/L and 0.66 mg/L larger than simulated values at the Lanjiang River mouth and the Yanlingwu, 0.16 mg/L, 0.54 mg/L and 0.49 mg/L smaller at the Zhaixi, the Yushan and the Yuanpu. For TP, the measured values are 0.13 mg/L and 0.14 mg/L higher than simulated values at the Meicheng Water facility and Yanlingwu. However, the measure values are slightly lower than simulated ones at Zhaixi, Yushan, Puyang River mouth and Yuanpu, the trend of which accords with actual situation. The results indicate that the contaminations of the Qiantang Reach mostly come from the Lanjiang River, the Fuchun River and the Puyang River on the upstream, among which the Lanjiang River and the Puyang River have a very high concentration of polluted materials, which means bad water quality, and influence the water downstream. The Lanjiang River becomes the chief contaminative source in the Fuchun River. When the discharge from the Xin'an River Dam is small, the recirculation region may be formed and makes part of the Xin'an Reach contaminated. Otherwise, when the discharge is large, the water quality in the Fuchun River is apparently improved. And the Puyang River, which brings the contaminations from the upstream, along with the polluted water let into it from the industries along the reach, has significant impacts on the water quality in Qiantang Reach.