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Rev Assoc Med Bras (1992) ; 70(3): e20230683, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38655992

RESUMO

OBJECTIVE: In this study, we aimed to determine the phenolic compounds, the antibacterial activity of extract from Laurus nobilis leaves, and its possible effect on transforming growth factor-ß1 expression level in peripheral blood mononuclear cells. METHODS: The phenolic components of Laurus nobilis were identified by the high-performance liquid chromatography method. The antibacterial activity of this extract was determined by disk diffusion and broth microdilution methods. The transforming growth factor-ß1 expression was analyzed using the RT-qPCR method. RESULTS: Epicatechin was found in the highest amount and o-coumaric acid in the lowest amount. The half-maximal inhibitory concentration (IC50) was determined to be 55.17 µg/mL. The zones of inhibition and minimum inhibitory concentration for Staphylococcus aureus, Enterococcus faecalis, and Klebsiella pneumoniae were 15, 14, and 8 mm and 125, 250, and 1000 µg/mL, respectively. The change in transforming growth factor-ß1 expression levels was found to be statistically significant compared with the control groups (p<0.0001). CONCLUSION: Laurus nobilis extract was found to be effective against bacteria and altered the expression level of transforming growth factor-ß1 in peripheral blood mononuclear cells.


Assuntos
Antibacterianos , Enterococcus faecalis , Laurus , Leucócitos Mononucleares , Testes de Sensibilidade Microbiana , Extratos Vegetais , Staphylococcus aureus , Fator de Crescimento Transformador beta1 , Humanos , Antibacterianos/farmacologia , Cromatografia Líquida de Alta Pressão , Enterococcus faecalis/efeitos dos fármacos , Concentração Inibidora 50 , Klebsiella pneumoniae/efeitos dos fármacos , Laurus/química , Leucócitos Mononucleares/efeitos dos fármacos , Fenóis/farmacologia , Fenóis/análise , Extratos Vegetais/farmacologia , Folhas de Planta/química , Staphylococcus aureus/efeitos dos fármacos , Fator de Crescimento Transformador beta1/efeitos dos fármacos , Fator de Crescimento Transformador beta1/metabolismo
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