Assessment of rTMS treatment effects for methamphetamine use disorder based on EEG microstates.

Microstates have been proposed as topographical maps representing large-scale resting-state networks and have recently been suggested as markers for methamphetamine use disorder (MUD). However, it is unknown whether and how they change after repetitive transcranial magnetic stimulation (rTMS) intervention. This study included a comprehensive subject population to investigate the effect of rTMS on MUD microstates. 34 patients with MUD underwent a 4-week randomized, double-blind rTMS intervention (active=17, sham=17). Two resting-state EEG recordings and VAS evaluations were conducted before and after the intervention period. Additionally, 17 healthy individuals were included as baseline controls. The modified k-means clustering method was used to calculate four microstates (MS-A∼MS-D) of EEG, and the FC network was also analyzed. The differences in microstate indicators between groups and within groups were compared. The durations of MS-A and MS-B microstates in patients with MUD were significantly lower than that in HC but showed significant improvements after rTMS intervention. Changes in microstate indicators were found to be significantly correlated with changes in craving level. Furthermore, selective modulation of the resting-state network by rTMS was observed in the FC network. The findings indicate that changes in microstates in patients with MUD are associated with craving level improvement following rTMS, suggesting they may serve as valuable evaluation markers.

The Paradigm Design of a Novel 2-class Unilateral Upper Limb Motor Imagery Tasks and its EEG Signal Classification.

Multitasking motor imagery (MI) of the unilateral upper limb is potentially more valuable in stroke rehabilitation than the current conventional MI in both hands. In this paper, a novel experimental paradigm was designed to imagine two motions of unilateral upper limb, which is hand gripping and releasing, and elbow reciprocating left and right. During this experiment, the electroencephalogram (EEG) signals were collected from 10 subjects. The time and frequency domains of the EEG signals were analyzed and visualized, indicating the presence of different Event-Related Desynchronization (ERD) or Event-Related Synchronization (ERS) for the two tasks. Then the two tasks were classified through three different EEG decoding methods, in which the optimized convolutional neural network (CNN) based on FBCNet achieved an average accuracy of 67.8%, obtaining a good recognition result. This work not only can advance the studies of MI decoding of unilateral upper limb, but also can provide a basis for better upper limb stroke rehabilitation in MI-BCI.

A deep neural network with subdomain adaptation for motor imagery brain-computer interface.

BACKGROUND: The nonstationarity problem of EEG is very serious, especially for spontaneous signals, which leads to the poor effect of machine learning related to spontaneous signals, especially in related tasks across time, which correspondingly limits the practical use of brain-computer interface (BCI). OBJECTIVE: In this paper, we proposed a new transfer learning algorithm, which can utilize the labeled motor imagery (MI) EEG data at the previous time to achieve better classification accuracies for a small number of labeled EEG signals at the current time. METHODS: We introduced an adaptive layer into the full connection layer of a deep convolution neural network. The objective function of the adaptive layer was designed to minimize the Local Maximum Mean Discrepancy (LMMD) and the prediction error while minimizing the distance within each class (DWC) and maximizing the distance between classes within each domain (DBCWD). We verified the effectiveness of the proposed algorithm on two public datasets. RESULTS: The classification accuracy of the proposed algorithm was higher than other comparison algorithms, and the paired t-test results also showed that the performance of the proposed algorithm was significantly different from that of other algorithms. The results of the confusion matrix and feature visualization showed the effectiveness of the proposed algorithm. CONCLUSION: Experimental results showed that the proposed algorithm can achieve higher classification accuracy than other algorithms when there was only a small amount of labeled MI EEG data at the current time. It can be promising to be applied to the field of BCI.

EEG classification across sessions and across subjects through transfer learning in motor imagery-based brain-machine interface system.

Transfer learning enables the adaption of models to handle mismatches of distributions across sessions or across subjects. In this paper, we proposed a new transfer learning algorithm to classify motor imagery EEG data. By analyzing the power spectrum of EEG data related to motor imagery, the shared features across sessions or across subjects, namely, the mean and variance of model parameters, are extracted. Then, select the data sets that were most relevant to the new data set according to Euclidean distance to update the shared features. Finally, utilize the shared features and subject/session-specific features jointly to generate a new model. We evaluated our algorithm by analyzing the motor imagery EEG data from 10 healthy participants and a public data set from BCI competition IV. The classification accuracy of the proposed transfer learning is higher than that of traditional machine learning algorithms. The results of the paired t test showed that the classification results of PSD and the transfer learning algorithm were significantly different (p = 2.0946e-9), and the classification results of CSP and the transfer learning algorithm were significantly different (p = 1.9122e-6). The test accuracy of data set 2a of BCI competition IV was 85.7% ± 5.4%, which was higher than that of related traditional machine learning algorithms. Preliminary results suggested that the proposed algorithm can be effectively applied to the classification of motor imagery EEG signals across sessions and across subjects and the performance is better than that of the traditional machine learning algorithms. It can be promising to be applied to the field of brain-computer interface (BCI). Graphical abstract.

A Framework on Optimization Strategy for EEG Motor Imagery Recognition.

At present, in the process of encephalogram motor imagery decoding, facing the background of big data analysis, it has the necessity to design an effective system which is subject-independent. Pre-training is common to carry out before each experiment, which affects the practicability of the EEG system. In order to solve this problem, the most feasible method is to design a unified framework for deep learning optimization, which could capture the spatial and spectral dependence of original motor imagery EEG signals according to the features extracted by CNN and the temporal dependence extracted by RNN-LSTM. The framework is superimposed from both end-to-end and time-frequency domains so as to retain and learn interpretable motor imagery features. In addition, artificial EEG signals can be automatically generated by training the generated adversarial network, which can generate the feature distribution similar to the original EEG signals, increase the capacity of EEG samples, and ultimately improve the classification performance and robustness of EEG motor imagery recognition. This deep learning framework can improve the classification accuracy of motor imagery for different subjects. In addition, the network can learn from the original data with the least amount of preprocessing, thus eliminating the time-consuming data preparation process.