RESUMO
Six new triterpenoid saponins, psychotrianosides A-F (1-6), and two known triterpenoid saponins, psychotrianoside G (7) and ardisianoside D (8), were isolated from Psychotria sp. Their structures were determined mainly by spectroscopic methods. The cytotoxic activities of 1-8 against five human cancer cell lines (MDA-MB-231, MCF-7, MCF-7/ADM, HepG2, and HepG2/ADM) are reported for the first time. Psychotrianoside C (3) showed the most potent antiproliferative activity among these saponins, and the IC50 value of 3 against MDA-MB-231 was 2.391 ± 0.161 µM. Compound 3 was also found to induce apoptosis.
Assuntos
Antineoplásicos Fitogênicos/farmacologia , Psychotria/química , Saponinas/farmacologia , Triterpenos/farmacologia , Antineoplásicos Fitogênicos/química , Apoptose , Linhagem Celular Tumoral , Proliferação de Células/efeitos dos fármacos , Sobrevivência Celular , Ensaios de Seleção de Medicamentos Antitumorais , Humanos , Concentração Inibidora 50 , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Caules de Planta/química , Saponinas/química , Saponinas/isolamento & purificação , Análise Espectral , Triterpenos/química , Triterpenos/isolamento & purificaçãoRESUMO
Two new metabolites, the cyclo-(L-Phe-L-Leu1-L-Leu2-L-Leu3-L-Ile) (1) and (3S,4R)-dihydroxy-(6S)-undecyl-alpha-pyranone (2) have been produced by the endophytic fungus no. 2524 isolated from a seed of mangrove Avicennia marina in Hong Kong. The structures have been elucidated by spectra including two-dimensional NMR, ESI tandem mass spectrometry and CD. These compounds show no activity toward human cancer cell lines Bel-7402, NCI-4460 and the normal human cell lines L-02.