Screening Technology for Traditional Chinese Medicine New Drug and Practice / 世界科学技术-中医药现代化

This article focused on summarization of the available new screening technology for traditional Chinese medicine (TCM) new drug, including high throughput screening (HTS), biological chip, molecular biological chro-matography, high content screening (HCS), network pharmacology, proteomics, and computer-aided drug design (CADD). And in this review, one example that we applied CADD technology (such as molecular docking, pharma-cophore and molecular similarity) in lipid-lowering TCM new drug development was given. Based on the mechanism of lipid metabolism, CADD technology provided a good method on the prescription optimization and mechanism study. In addition, TCM new drug development proposal which displayed in this paper may provide a useful strategy for screening of TCM new drug.

Application of near-infrared spectroscopy technology in quality control of TCM manufacturing process / 中国中药杂志

With the development of research in near-infrared spectroscopy technology, near-infrared spectroscopy are increasingly employed in quality control of traditional Chinese medicine (TCM) manufacturing process. The recent researches in relative field were summarized in this paper. Perspective of near-infrared spectroscopy technology in quality control of TCM manufacturing process was also presented in this paper.

Study on quality control of herbal material of paeony formula granule by near infrared diffuse reflection spectroscopy / 中国中药杂志

<p><b>OBJECTIVE</b>To develop a novel method to determine fastly and nondestructively the content of paeoniflorin, albiflorin and moisture in Radix Paeoniae Alba with near infrared diffuse reflection spectroscopy.</p><p><b>METHOD</b>Multivariate calibration models based on PLS algorithm were developed to correlate the spectra and the corresponding values determined by the reference method.</p><p><b>RESULT</b>The corelation coefficients (R2) of the calibration models were 0.938, 0.943 and 0.976, and the prediction average relative deviation for paeoniflorin, albiflorin and moisture content were 6.5%, 0.23% and 3.8%, respectively.</p><p><b>CONCLUSION</b>The NIRS determination method is rapid, accurate, nondestructive and non-pollution. It can dispose the samples without complicated pretreatment. It is qualified to analyze rapidly traditional Chinese medicine whose components are complex. NIRS can be used to control the quality of herbal material of paeony formula granule.</p>