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Métodos Terapêuticos e Terapias MTCI
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1.
Head Neck ; 38 Suppl 1: E761-70, 2016 04.
Artigo em Inglês | MEDLINE | ID: mdl-25914292

RESUMO

BACKGROUND: Various chemotherapeutic agents have been used largely for the treatment of salivary gland cancer. However, results are disappointing, and these agents can cause some serious side effects. Therefore, recent studies have focused on the possible roles of natural products to overcome these limitations. METHODS: Salivary gland cancer cells treated with or without Convallaria keiskei (MECK) for 24 hours. Apoptotic changes were evaluated by live/dead assay, immunoblotting, and expression levels of caspase-3 and B-cell lymphoma-2 family member. RESULTS: MECK significantly inhibited salivary gland cancer growth. At the molecular level, MECK dramatically reduced myeloid cell leukemia-1 (Mcl-1) in a translation-dependent manner and thereby induced apoptosis through Bax/Bid. Furthermore, we found that Mcl-1 could be a potential therapeutic target of MECK-induced apoptosis and its stability is regulated by extracellular signal-regulated kinases 1/2 (ERK1/2) signaling CONCLUSION: MECK can be used as a safe and efficient therapeutic alternative for the treatment of salivary gland cancer. © 2015 Wiley Periodicals, Inc. Head Neck 38: E761-E770, 2016.


Assuntos
Convallaria/química , Proteína de Sequência 1 de Leucemia de Células Mieloides/antagonistas & inibidores , Fitoterapia , Extratos Vegetais/farmacologia , Neoplasias das Glândulas Salivares/tratamento farmacológico , Apoptose , Caspase 3/metabolismo , Linhagem Celular Tumoral , Humanos , Terapia de Alvo Molecular , Proteínas Proto-Oncogênicas c-bcl-2/metabolismo , RNA Interferente Pequeno
2.
Am J Chin Med ; 35(2): 241-50, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-17436365

RESUMO

The potential recovery effect by oculo-acupuncture (OA) on ethylene glycol-induced acute renal injury in dogs was investigated. Acute renal damage was induced by ingestion of ethylene glycol in six mongrel dogs. The dogs were assigned to control (three dogs) and experimental (three dogs) groups. The control group did not receive any treatment, while the experimental group was treated with oculo-acupuncture at kidney/urinary bladder region plus zhong jiao region of the eyes after the induction of renal damage. Serum blood urea nitrogen (BUN), creatinine, sodium (Na), chloride (Cl), and potassium (K) were measured in both control and experimental groups. The blood RBC and Hb were also examined. The serum BUN and creatinine activities in the experimental group were lower than those in the control group, the serum Na and Cl had the irregular change in both groups, and the blood Hb in the control and experimental group showed decreasing tendency. Significant differences were observed on the 3rd and 7th day in BUN, 7th day in creatinine, 2nd day in Na and Cl, and 7th day in Hb when compared to the control group. Whereas, serum K concentration and RBC in the experimental group did not change significantly. The recovery findings of the renal injury were also observed in the experimental group histopathologically. In conclusion, OA therapy (kidney/urinary bladder region plus zhong jiao region) was effective for recovery of the renal injury induced by ethylene glycol in dogs.


Assuntos
Terapia por Acupuntura , Injúria Renal Aguda/induzido quimicamente , Injúria Renal Aguda/terapia , Etilenoglicol/efeitos adversos , Olho , Pontos de Acupuntura , Animais , Nitrogênio da Ureia Sanguínea , Cloretos/sangue , Creatinina/sangue , Cães , Epitélio/fisiologia , Feminino , Hemoglobinas/análise , Rim/patologia , Masculino , Potássio/sangue , Regeneração , Sódio/sangue
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