Research advance in the mechanism exploration of traditional Chinese medicine regulating mucus barrier and interfering with ulcerative colitis based on the “thickening intestine”theory / 中国药房

Ulcerative colitis （UC） is a clinical chronic intestinal disease， and the damage of the intestinal epithelial mucus barrier is an important pathological mechanism of UC. Mucin 2 （MUC2） is a major component of the intestinal mucus barrier， and goblet cells are the “main force” of MUC2 secretion， maintaining and renewing the intestinal mucus layer to ensure its integrity. Therefore， repairing the intestinal mucus barrier by promoting the synthesis of MUC2 by goblet cells is an important strategy for the treatment of UC. Traditional Chinese medicine scholars believe that there is an inherent layer of “lipid membrane” or “fat paste” in the intestine， and pathological factors such as moisture and heat lead to the thinning of this structure， which is the fundamental pathogenesis of “diarrhea” and “intestinal dysentery”. It coincides with the damage of intestinal mucus barrier leading to UC in modern medicine. Based on this， this paper summarized the mechanism of Chinese herbal compounds or Chinese herbal active components in regulating intestinal mucus barrier to interfere with UC. It was found that Chinese herbal compounds such as Huanglian jiedu decoction， Shaoyao decoction and Compound Kusen decoction， as well as Chinese herbal active ingredients such as volatile oil of Atractylodes lancea， paeoniflorin and papaya triterpenes could promote the synthesis and secretion function of goblet cells， and achieve the purpose of “thickening intestine”， thus relieving UC symptoms.

Summarization of the Experience of Luteinized Unruptured Follicle Syndrome's Treatment by Professor TAN Yong / 浙江中医药大学学报

[Objective] This paper introduces the experience of Professor TAN Yong's treatment of the luteinized unruptured follicle syndrome(LUFS) with a view to provide references for the related study.[Methods]Through studying with Professor TAN, collecting and analyzing clinical case data, researching editorial book and articles. From the etiology, pathogenesis and drug selection of the LUFS, the clinical experience of the teacher was discussed, Professor TAN's academic characteristics on the treatment of LUFS were summarized, and a medical case was provided to support the idea.[Results]Professor TAN believes that the pathogenesis of this disease is mostly due to deficiency of the kidney Yin, the weak Yang qi, Yin and Yang conversion is unfavorable during intermenstrual period, combined with pathological factors such as liver depression, blood stasis, and phlegm dampness. Unsmooth running of Qi and blood, so that the follicular can not be discharged smoothly, the disease occurs. In the treatment of combination of Traditional Chinese Medicine(TCM) and western Medicine, in the intermenstrual period attach importance to the function of the heart and brain, to tonifying kidney and blood circulation as a method, the use of "Tonifying Kidney Stimulating Ovulation" medicine treatment, combined with western medicine, in the clinically achieved good results. The medical case was based on the "Tonifying kidney Stimulating Ovulation" medicine as the basis for the successful pregnancy after the treatment, which fully proved the above mentioned dialectical thinking and treatment experience. [Conclusion]It is worthwhile to learn and promote the treatment of LUFS with tonifying kidney and blood circulation therapy.

Test-retest reliability of Mandarin acceptable noise level / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To evaluate test-retest reliability of Mandarin acceptable noise level(M-ANL) test materials.@*METHOD@#M-ANL was evaluated during three test sessions approximately one week apart, by testing 30 Mandarin-speaking people aged from 21 to 28 with normal aural/oral communication abilities. The participants completed the preference for background noise questionnaire before the first session. Analysis of the test-retest results were administered by SPSS 17.0 (Statistically Package for the Social Sciences Software Version 17.0).@*RESULT@#ANLs in the three sessions were (8.1 +/- 2.9), (7.4 +/- 2.2), (7.6 +/- 2.5)dB S/N, respectively. The correlation coefficients were 0.722, 0.746 and 0.849 between two of the three sessions. The correlation coefficients of the ANL and 7 questions of the questionnaire were below 0.3.@*CONCLUSION@#M-ANL test materials are found to have good test-retest reliability. Listeners' preference for background noise is not related to their acceptance of background noise. Listeners cannot accurately assess their ability to accept background noise.