RESUMO
THE AIM OF THE STUDY: Was to assess the impact of two toothpastes marked as «Whitening¼ and two electric toothbrushes on the dental health values of young adults aged 18-25 years. MATERIAL AND METHODS: The study comprised 139 young adults 18-25 years old participated to assess the improvement of dental index score in dynamic observation. The study groups were formed by random sampling. RESULTS: The effectiveness of two types of electric toothbrushes in combination with two different toothpastes has been studied. Significant improvement of oral health indices in 3 months of investigation was found in the study group with sonic electric brush and toothpaste specially designed for use with electric toothbrushes (p<0.01). CONCLUSION: The study showed the benefit of combined use of sonic electric brush and low abrasive toothpaste containing bromelain, xylite, calcium glycerophosphate and magnesium chloride for dental health of young adults aged 18-25 years.
Assuntos
Escovação Dentária , Cremes Dentais , Adulto Jovem , Humanos , Adolescente , Adulto , BromelaínasRESUMO
Chronic intranasal administration of antibodies to glutamate to aging C57Bl/6 mice improved passive avoidance conditioning, had no effect on horizontal and vertical locomotor activity, but slowed locomotion in the open-field test. Administration of antibodies to glutamate increased the content of dopamine and its metabolites in mouse hippocampus, but had no effect on the metabolism of neurotransmitter amino acids. In the frontal cortex, antibodies to glutamate did not affect neurotransmitter metabolism, but increased the level of both excitatory and inhibitory amino acids without changing their ratio.
Assuntos
Envelhecimento/fisiologia , Anticorpos/farmacologia , Aprendizagem da Esquiva/efeitos dos fármacos , Antagonistas de Aminoácidos Excitatórios/farmacologia , Ácido Glutâmico/metabolismo , Memória/efeitos dos fármacos , Administração Intranasal , Animais , Anticorpos/química , Ácido Aspártico/metabolismo , Aprendizagem da Esquiva/fisiologia , Condicionamento Psicológico/efeitos dos fármacos , Condicionamento Psicológico/fisiologia , Dopamina/metabolismo , Antagonistas de Aminoácidos Excitatórios/química , Lobo Frontal/efeitos dos fármacos , Lobo Frontal/fisiologia , Glicina/metabolismo , Haptenos/química , Hipocampo/efeitos dos fármacos , Hipocampo/fisiologia , Ácido Hidroxi-Indolacético/metabolismo , Imunoconjugados/química , Locomoção/efeitos dos fármacos , Locomoção/fisiologia , Masculino , Memória/fisiologia , Camundongos , Camundongos Endogâmicos C57BL , Coelhos , Serotonina/metabolismo , Soroalbumina Bovina/química , Ácido gama-Aminobutírico/metabolismoRESUMO
We studied the effects of intranasal administration of antiglutamate antibodies on the development of stress response and level of neurotransmitter amino acids and monoamines in brain structures of rats with different initial behavioral activity. The stress exposure was followed by significant changes in behavioral activity and concentration of neurotransmitters in rat hippocampus and hypothalamus. The changes in the level of neurotransmitter amino acids and monoamines were more pronounced in the hippocampus. Antiglutamate antibodies administered intranasally in a single dose of 250 µg/kg immediately after stress exposure prevented the development of the stress response and normalized the level of neurotransmitters in the brain structures of rats. The effect of antibodies was the most pronounced in behaviorally active rats.
Assuntos
Anticorpos/farmacologia , Ácido Glutâmico/imunologia , Hipocampo/metabolismo , Hipotálamo/metabolismo , Neurotransmissores/metabolismo , Estresse Fisiológico/efeitos dos fármacos , Administração Intranasal , Animais , Anticorpos/administração & dosagem , Comportamento Animal/fisiologia , Masculino , Ratos , Ratos WistarRESUMO
The intranasal administration of glutamate antibodies in the dose of 300 microg/kg one hour after damage on the level of mRNA expression of Dffb gene which codes caspase-activated DNase which participates in intranucleosome fragmentation of genome DNA in apoptosis was investigated in experimental Alzheimer's disease induced by injection of neurotoxic fragment of beta-amyloid protein Abeta25-35 in Meynert basal magnocellular nuclei on rats. On the Day 3 after Abeta25-35 injection is observed significant decrease of the level of mRNA expression of Dffb gene in prefrontal cortex in 37%, and in hippocampus in 62% in the experiment group versus the control group. These differences were not found in the hypothalamus when comparing the experimental and control animals. It was suggested that repressive effect of glutamate antibodies on the level of mRNA expression of Dffb gene reflects stabilization of processes taking place in brain cells in experimental Alzheimer's disease, and in its turn the intensiveness of nerve and glial cells apoptotic death is decreased.